Results 101 to 110 of about 120,368 (286)

Sequence heterogeneity and the dynamics of molecular motors [PDF]

, 2005
The effect of sequence heterogeneity on the dynamics of molecular motors is reviewed and analyzed using a set of recently introduced lattice models. First, we review results for the influence of heterogenous tracks such as a single-strand of DNA or RNA on the dynamics of the motors.
arxiv   +1 more source

ERNEST COST action overview on the (patho)physiology of GPCRs and orphan GPCRs in the nervous system

British Journal of Pharmacology, EarlyView.
G protein‐coupled receptors (GPCRs) are a large family of cell surface receptors that play a critical role in nervous system function by transmitting signals between cells and their environment. They are involved in many, if not all, nervous system processes, and their dysfunction has been linked to various neurological disorders representing important
Necla Birgül Iyison, Clauda Abboud, Dayana Abboud, Abdulrasheed O. Abdulrahman, Ana‐Nicoleta Bondar, Julie Dam, Zafiroula Georgoussi, Jesús Giraldo, Anemari Horvat, Christos Karoussiotis, Alba Paz‐Castro, Miriam Scarpa, Hannes Schihada, Nicole Scholz, Bilge Güvenc Tuna, Nina Vardjan   +15 more
wiley   +1 more source

The structural basis of ATP as an allosteric modulator.

PLoS Computational Biology, 2014
Adenosine-5'-triphosphate (ATP) is generally regarded as a substrate for energy currency and protein modification. Recent findings uncovered the allosteric function of ATP in cellular signal transduction but little is understood about this critical ...
Shaoyong Lu, Wenkang Huang, Qi Wang, Qiancheng Shen, Shuai Li, Ruth Nussinov, Jian Zhang   +6 more
doaj   +1 more source

Current knowledge and recent advances in understanding metabolism of the model cyanobacterium Synechocystis sp. PCC 6803 [PDF]

, 2020
Cyanobacteria are key organisms in the global ecosystem, useful models for studying metabolic and physiological processes conserved in photosynthetic organisms, and potential renewable platforms for production of chemicals.
Lea-Smith, David, McCormick, Alistair J., Mills, Lauren   +2 more
core   +2 more sources

Glutaminase‐1 Mediated Glutaminolysis to Glutathione Synthesis Maintains Redox Homeostasis and Modulates Ferroptosis Sensitivity in Cancer Cells

Cell Proliferation, EarlyView.
GLS1‐mediated glutaminolysis supports GSH synthesis in cancer cells. GLS1 KO increases ROS, downregulates GPX4, and upregulates GPX1, making cells more sensitive to ferroptosis. Combining GLS1 or GPX1 inhibitors with a GPX4 inhibitor synergistically suppresses cancer growth.
Changsen Bai, Jialei Hua, Donghua Meng, Yue Xu, Benfu Zhong, Miao Liu, Zhaosong Wang, Wei Zhou, Liming Liu, Hailong Wang, Yang Liu, Lifang Li, Xiuju Chen, Yueguo Li   +13 more
wiley   +1 more source

Filamentation and inhibition of prokaryotic CTP synthase with ligands

mLife
Cytidine triphosphate synthase (CTPS) plays a pivotal role in the de novo synthesis of cytidine triphosphate (CTP), a fundamental building block for RNA and DNA that is essential for life.
Chenjun Guo, Zixuan Wang, Ji‐Long Liu
doaj   +1 more source

Cell‐specific genome‐scale metabolic modeling of SARS‐CoV‐2‐infected lung to identify antiviral enzymes

FEBS Open Bio, 2023
Computational systems biology plays a key role in the discovery of suitable antiviral targets. We designed a cell‐specific, constraint‐based modeling technique for severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2)‐infected lungs.
Ke‐Lin Chen, Feng‐Sheng Wang
doaj   +1 more source

Evading innate immunity in nonviral mRNA delivery : don't shoot the messenger [PDF]

, 2016
In de field of non-viral gene therapy, in vitro transcribed (IVT) mRNA has emerged as a promising tool for the delivery of genetic information. Over the past few years it has become widely known the introduction of IVT mRNA into mammalian cells elicits ...
Akira, Akira, Akira, Alexopoulou, Allen, Anderson, Anderson, Andries, Angel, Auphan, Awe, Baba, Balachandran, Ballas, Banchereau, Bhattacharyya, Bonehill, Borden, Carroll, Chauhan, Clark, Coller, Conry, Courreges, Dewitte, Dewitte, Diebold, Diebold, Diken, Drews, El-Sayed, Fotin-Mleczek, Gallie, Garcia, George, Goubau, Grudzien-Nogalska, Gupta, Hacker, Halpern, Harii, Hartner, He, Heil, Heleen Dewitte, Heufler, Hoerr, Hornung, Hu, Ikeda, Ingrand, Israel, Jammi, Jha, Jha, Jirikowski, Joke Devoldere, Kallen, Kambara, Kanneganti, Kariko, Kariko, Kariko, Kariko, Kariko, Kariko, Katrien Remaut, Kawai, Kettle, Komuro, Kormann, Koski, Kreiter, Krieg, Krieg, Kumar, Kumar, Kuznik, Lee, Leonhardt, Li, Liniger, Loiarro, Lonez, Lorenz, Mandal, Mantovani, Martin, Martinon, Mays, Myskiw, Nallagatla, Nallagatla, Nekhai, Okumura, Pardi, Pascolo, Pascolo, Pathak, Pfaller, Pichlmair, Pichlmair, Pichlmair, Plews, Pollard, Qiu, Quintas-Cardama, Quintas-Cardama, Rajsbaum, Rejman, Rettig, Rothenfusser, Rowland, Sabbah, Sadler, Sahin, Samuel, Satoh, Scheel, Scheinman, Schlee, Schmidt, Schmolke, Schwartz, Sen, Silverman, Smith, Stefaan C. De Smedt, Sugiyama, Takahashi, Tang, Tavernier, Tavernier, Toshchakov, Tros de Ilarduya, Van Lint, Wang, Wang, Warren, Warren, Wells, Wolff, Xiang, Yakubov, Yamamoto, Yang, Yoneyama, Yoneyama, Yoshioka, Zangi, Zhu, Zhu, Zust   +152 more
core   +1 more source

The genetic code invariance: when Euler and Fibonacci meet [PDF]

Symmetry: Culture and Science, Vol.25, No.3, 145-288, 2014, 2014
The number of atoms in the four ribonucleotides uridine monophosphate, cytidine monophosphate, adenine monophosphate and guanine monophosphate is taken as a key parameter. A mathematical relation describing the condensation of the three basic subunits a nucleobase, a ribose and a phosphate group, to form a ribonucleotide, is first obtained from this ...
arxiv  

Y12C mutation disrupts IMPDH cytoophidia and alters cancer metabolism

The FEBS Journal, EarlyView.
IMPDH, the rate‐limiting enzyme for de novo GTP synthesis, can form polymers and cytoophidia to enhance activity by reducing GTP inhibition. In this study, a Y12C mutation in IMPDH2 was introduced via ABEmax base‐editing in human cancer cell lines to disrupt IMPDH polymerisation.
Chia‐Chun Chang, Min Peng, Gerson Dierley Keppeke, Li‐Kuang Tsai, Ziheng Zhang, Li‐Mei Pai, Li‐Ying Sung, Ji‐Long Liu   +7 more
wiley   +1 more source