Results 111 to 120 of about 120,368 (286)

Dual Signaling Pathways of Arterial Constriction by Extracellular Uridine 5′-Triphosphate in the Rat

Journal of Pharmacological Sciences, 2011
We investigated actions of uridine 5′-triphosphate (UTP) in rat aorta, cerebral and mesenteric arteries, and their single myocytes. UTP (≥10 μM) elicited an inward-rectifying current strongly reminiscent of activation of P2X1 receptor, and a similar ...
Megumi Sugihara, Hiromitsu Morita, Miho Matsuda, Hisanori Umebayashi, Shunichi Kajioka, Shinichi Ito, Motohiro Nishida, Ryosuke Inoue, Toshiko Futatsuki, Jun Yamazaki, Yasuo Mori, Ryuji Inoue, Yushi Ito, Kihachiro Abe, Masato Hirata   +14 more
doaj  

Enzymatic phosphorylation of uridine and cytidine using calcium‐based dual‐enzyme nanoflowers

Food Bioengineering
Nucleotides, such as uridine 5′‐monophosphate (5′‐UMP) and cytidine 5′‐monophosphate (5′‐CMP), are heavily demanded as food additives, dietary supplements, and medicinal intermediates.
Ziye Zhao, Ning Nie, Xinwei Li, Ye Shi, Xudong Liu, Yifei Zhang   +5 more
doaj   +1 more source

The Structures, Functions, and Evolution of Sm-like Archaeal Proteins (SmAPs) [PDF]

arXiv, 2016
Sm proteins were discovered nearly 20 years ago as a group of small antigenic proteins ($\approx$ 90-120 residues). Since then, an extensive amount of biochemical and genetic data have illuminated the crucial roles of these proteins in forming ribonucleoprotein (RNP) complexes that are used in RNA processing, e.g., spliceosomal removal of introns from ...
arxiv  

The Power Duo: How the Interplay Between Nucleoid‐Associated Proteins and Small Noncoding RNAs Orchestrates the Cellular Regulatory Symphony

Molecular Microbiology, EarlyView.
Nucleoid‐associated proteins play a crucial role in the compaction of bacterial DNA and the regulation of gene expression. The emergence of small noncoding RNAs as regulatory elements in these processes represents a major development in our understanding of bacterial biology.
Sara Moutacharrif, Feth El Zahar Haichar, Sam Meyer, Cecile Ribot, Sylvie Reverchon, William Nasser, Florence Hommais   +6 more
wiley   +1 more source

Design of Potential Anti-Leishmanial Pharmacophores via In Silico Drug Repurposing

Journal of Ardabil University of Medical Sciences, 2020
Background & objectives: Drug-repurposing is the study on application of existing drugs for treatment or control of other diseases. Major advantage of the technique relies on a nominated drug molecule that is applied for pharmacodynamics optimization due
Sana Ahdeno, Nima Razaghi-Asl, Behnam Mohammadi-ghalehbin   +2 more
doaj  

Anatomical Distribution of Nucleoside System in the Human Brain and Implications for Therapy [PDF]

, 2013
Nucleosides have a wide range of physiological and pathophysiological roles in the human brain as modulators of a variety of neural functions. For example, adenosine, inosine, guanosine, and uridine participate in the mechanisms underlying memory ...
Dobolyi, Árpád, Kovács, Zsolt
core   +1 more source

Kinetic Analysis of Protein Assembly on the Basis of the Center Manifold around the Critical Point [PDF]

arXiv, 2015
Protein assembly plays an important role in the regulation of biological systems. The cytoskeleton assembly activity is provided by the binding cofactors GTP (guanidine triphosphate) or ATP(adenosine triphosphate) to monomeric protein, and is initiated by assembling the monomeric proteins.
arxiv  

Fluorescent nanodiamonds for FRET-based monitoring of a single biological nanomotor FoF1-ATP synthase [PDF]

, 2009
Color centers in diamond nanocrystals are a new class of fluorescence markers that attract significant interest due to matchless brightness, photostability and biochemical inertness. Fluorescing diamond nanocrystals containing defects can be used as markers replacing conventional organic dye molecules, quantum dots or autofluorescent proteins. They can
arxiv   +1 more source

Management of T‐cell malignancies: Bench‐to‐bedside targeting of epigenetic biology

CA: A Cancer Journal for Clinicians, EarlyView.
Abstract The peripheral T‐cell lymphomas (PTCL) are the only disease for which four histone deacetylase (HDAC) inhibitors have been approved globally as single agents. Although it is not clear why the PTCL exhibit such a vulnerability to these drugs, understanding the biological basis for this activity is essential.
Ariana Sabzevari, Johnson Ung, Jeffrey W. Craig, Kallesh D. Jayappa, Ipsita Pal, David J. Feith, Thomas P. Loughran Jr, Owen A. O’Connor   +7 more
wiley   +1 more source

In vitro Assessment of RNA Polymerase I Activity

Bio-Protocol, 2017
In eukaryotic cells transcriptional processes are carried out by three different RNA polymerases: RNA polymerase I which specifically transcribes ribosomal RNA (rRNA), RNA polymerase II which transcribes protein-coding genes to yield messenger RNAs ...
Marzia Govoni
doaj   +1 more source