Results 141 to 150 of about 120,368 (286)

Effects of 4(1H)-quinolinone derivative, a novel non-nucleotide allosteric purinergic P2Y 2 agonist, on cardiomyocytes in neonatal rats

open access: yesScientific Reports, 2017
Purinergic P2Y 2 receptors, G-protein coupled receptors that primarily couple with Gαq/11-proteins, are activated equipotently by adenosine-5′-triphosphate (ATP) and uridine-5′-triphosphate.
Kensuke Sakuma   +4 more
doaj   +1 more source

Depression of presynaptic excitation by the activation of vanilloid receptor 1 in the rat spinal dorsal horn revealed by optical imaging

open access: yesMolecular Pain, 2006
In this study, we show that capsaicin (CAP) depresses primary afferent fiber terminal excitability by acting on vanilloid receptor 1 (TRPV1 channels) of primary afferent fibers in adenosine 5'-triphosphate (ATP)- and temperature-dependent manner using ...
Ikeda Hiroshi   +2 more
doaj   +1 more source

The Iron-Type Nitrile Hydratase Activator Protein Is A GTPase [PDF]

open access: yes, 2017
The Fe-type nitrile hydratase activator protein from Rhodococcus equi TG328-2 (ReNHase TG328-2) was successfully expressed and purified. Sequence analysis and homology modeling suggest that it is a G3E P-loop guanosine triphosphatase (GTPase) within the ...
Bennett, Brian   +3 more
core   +1 more source

Active transport: A kinetic description based on thermodynamic grounds [PDF]

open access: yesarXiv, 2004
We show that active transport processes in biological systems can be understood through a local equilibrium description formulated at the mesoscale, the scale to describe stochastic processes. This new approach uses the method established by nonequilibrium thermodynamics to account for the irreversible processes occurring at this scale and provides ...
arxiv  

P2Y receptors in the mammalian nervous system: pharmacology, ligands and therapeutic potential [PDF]

open access: yes, 2012
P2Y receptors for extracellular nucleotides are coupled to activation of a variety of G proteins and stimulate diverse intracellular signaling pathways that regulate functions of cell types that comprise the central nervous system (CNS).
Erb, Laurie   +3 more
core   +1 more source

The Isolation of Uridine-5'-Triphosphate from Muscle. [PDF]

open access: bronze, 1954
Rolf Bergkvist   +3 more
openalex   +1 more source

P2Y11 receptors : properties, distribution and functions [PDF]

open access: yes, 2017
The P2Y11 receptor is a G protein-coupled receptor that is stimulated by endogenous purine nucleotides, particularly ATP. Amongst P2Y receptors it has several unique properties; 1) it is the only human P2Y receptor gene that contains an intron in the ...
Kennedy, Charles
core   +1 more source

5'-nucleotidases, nucleosides and their distribution in the brain: pathological and therapeutic implications [PDF]

open access: yes, 2013
Elements of the nucleoside system (nucleoside levels, 5'-nucleotidases (5'NTs) and other nucleoside metabolic enzymes, nucleoside transporters and nucleoside receptors) are unevenly distributed in the brain, suggesting that nucleosides have region ...
Dobolyi, Árpád   +3 more
core  

Human adipose‐derived multipotent stromal cells enriched with IL‐10 modRNA improve diabetic wound healing: Trigger the macrophage phenotype shift

open access: yesBioengineering & Translational Medicine
Diabetic wounds present a significant challenge in regenerative medicine due to impaired healing, characterized by prolonged inflammation and deficient tissue repair, primarily caused by a skewed pro‐inflammatory macrophage phenotype.
Yuxin Zhang   +9 more
doaj   +1 more source

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