Results 231 to 240 of about 120,368 (286)

Pyrimidines maintain mitochondrial pyruvate oxidation to support de novo lipogenesis. [PDF]

Science
Sahu U, Villa E, Reczek CR, Zhao Z, O'Hara BP, Torno MD, Mishra R, Shannon WD, Asara JM, Gao P, Shilatifard A, Chandel NS, Ben-Sahra I.   +12 more
europepmc   +1 more source

Cytidine deaminase-dependent mitochondrial biogenesis as a potential vulnerability in pancreatic cancer cells. [PDF]

Commun Biol
Frances A, Lumeau A, Bery N, Gayral M, Stuani L, Sorbara M, Saland E, Pagan D, Hanoun N, Torrisani J, Lemarié A, Portais JC, Buscail L, Dusetti N, Sarry JE, Cordelier P.   +15 more
europepmc   +1 more source

Deciphering Colorectal Cancer-Hepatocyte Interactions: A Multiomics Platform for Interrogation of Metabolic Crosstalk in the Liver-Tumor Microenvironment. [PDF]

Int J Mol Sci
Nelson AB, Reese LE, Rono E, Queathem ED, Qiu Y, McCluskey BM, Crampton A, Conniff E, Cummins K, Boytim E, Dansou S, Hwang J, Safo SE, Puchalska P, Wood DK, Schwertfeger KL, Crawford PA.   +16 more
europepmc   +1 more source

Use of metabolic imaging to monitor heterogeneity of tumour response following therapeutic mTORC1/2 pathway inhibition.

Dis Model Mech
Ling S, Dexter A, Race AM, Sharma S, Hamm G, Polanska UM, Rosetta Consortium Cancer Research UK, Marshall JF, Takats Z, Brindle K, Yuneva MO, Poulogiannis G, Campbell AD, Sansom OJ, Goodwin RJA, Bunch J, Barry ST.   +16 more
europepmc   +1 more source

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Uridyl Transferases and the Formation of Uridine Triphosphate: Enzymic Production of Uridine Triphosphate: Uridine Diphosphoglucose Pyrophosphorolysis

Nature, 1953
Uridyl Transferases and the Formation of Uridine Triphosphate: Enzymic Production of Uridine Triphosphate: Uridine Diphosphoglucose ...
Enrico Cutolo, Evelyn E. B. Smith, Herman M. Kalckar, Agnete Munch-Petersen   +3 more
openaire   +4 more sources

Feedback onhibition of uridine kinase by cytidine triphosphate and uridine triphosphate

Biochimica et Biophysica Acta (BBA) - Specialized Section on Nucleic Acids and Related Subjects, 1964
Abstract Uridine kinase was found to be the rate-limiting step in the anabolism of uridine to its successive nucleotide derivatives. This enzymatic activity was susceptible to feedback inhibition by the pyrimidine nucleoside triphosphate end-products; effective inhibition was exerted by UTP and even more strikingly by CTP.
E.P. Anderson, E.P. Anderson, R.W. Brockman, R.W. Brockman   +3 more
openaire   +4 more sources

Mechanisms of coronary artery depolarization by uridine triphosphate

American Journal of Physiology-Heart and Circulatory Physiology, 2001
We sought to define the basic mechanisms by which pyrimidine nucleotides constrict rat coronary resistance arteries. Uridine triphosphate (UTP) caused a dose-dependent constriction in coronary arteries stripped of endothelium. UTP also depolarized and increased cytosolic Ca2+in coronary smooth muscle cells.
Donald G. Welsh, Joseph E. Brayden
openaire   +4 more sources

Secretion of ATP from Schwann cells in response to uridine triphosphate

European Journal of Neuroscience, 2005
AbstractThe mechanisms by which uridine triphosphate (UTP) stimulates ATP release from Schwann cells cultured from the sciatic nerve were investigated using online bioluminescence techniques. UTP, a P2Y2 and P2Y4 receptor agonist, stimulated ATP release from Schwann cells in a dose‐dependent manner with an ED50 of 0.24 µm.
Eryn L. Werry, Max R. Bennett, Guo Jun Liu   +2 more
openaire   +4 more sources

Uridine triphosphate (UTP) is released during cardiac ischemia [PDF]

International Journal of Cardiology, 2005
Extracellular uridine triphosphate (UTP) stimulates vasodilatation, automaticity in ventricular myocytes and release of tissue-plasminogen activator (t-PA), indicating that UTP may be important in cardiac regulation. We took advantage of a recently developed quantitative assay for UTP to test the hypothesis that UTP is released in the circulation ...
Jan Harnek, Sverker Jern, Göran K. Olivecrona, Eduardo R. Lazarowski, Catharina van Heusden, David Erlinge   +5 more
openaire   +3 more sources

Mechanisms of secretion of ATP from cortical astrocytes triggered by uridine triphosphate

NeuroReport, 2003
The mechanisms involved in autocrine ATP release from cultured astrocytes isolated from the rat cortex were investigated using an online bioluminescence technique. Astrocytes released ATP in response to application of 10 microM uridine triphosphate, which was blocked by the non-specific purinergic receptor antagonist suramin.
Max R. Bennett, Guo Jun Liu, Andrea Abdipranoto, Eryn L. Werry   +3 more
openaire   +4 more sources