Results 41 to 50 of about 126,321 (267)

Challenges of drug resistance in the management of pancreatic cancer [PDF]

, 2010
The current treatment of choice for metastatic pancreatic cancer involves single agent gemcitabine or combination of gemcitabine with capecitabine and erlotinib (tyrosine kinase inhibitor).
Akada, Allison, Almoguera, Andreetta, Arai, Arlt, Arteaga, Arumugam, Asano, Bachem, Baldwin, Banerjee, Bartsch, Bergers, Best, Bold, Bondar, Buck, Burris, Chakravarti, Chakravarti, Choi, Cunningham, Cunningham, Dancer, Dong, Duxbury, Duxbury, Duxbury, Duxbury, Engelman, Feldmann, Ferrero, Galmarini, Geyer, Giovannetti, Goan, Greer, Hagmann, Hahn, Henke, Hruban, Humeniuk, Ischenko, Ishikawa, Itoi, Jansen, Karapetis, Kindler, Kong, Koopman, Kulik, Lei, Lemoine, Liau, Liau, Longley, Mackey, Mackey, Mackey, Mahon, Mamaghani, Marechal, Marmor, Martin Clynes, Mata, Maxwell, Mendelsohn, Meropol, Miwa, Moertel, Molina-Arcas, Moore, Morgillo, Moriyama, Muerkoster, Muerkoster, Nakahira, Nakajima, Nakano, Naomi Walsh, Nishimura, Oguri, Okamoto, Okumura, Olive, O’Driscoll, Pao, Park, Park, Peters, Plunkett, Ray McDermott, Ritzel, Rizwan Sheikh, Robert O’Connor, Ruggeri, Safran, Saito, Sakamoto, Schuller, Sebastiani, Shah, Shi, Simon, Spratlin, Takao, Takebayashi, Treat, Tsukamoto, Tzeng, Vaishampayan, Van Cutsem, van der Wilt, Wang, Wang, Wang, Xiong, Yamasaki, Yokoi   +119 more
core   +1 more source

Identifying metabolites by integrating metabolome databases with mass spectrometry cheminformatics. [PDF]

, 2018
Novel metabolites distinct from canonical pathways can be identified through the integration of three cheminformatics tools: BinVestigate, which queries the BinBase gas chromatography-mass spectrometry (GC-MS) metabolome database to match unknowns with ...
A El-Tayeb, AD Hanson, AL Hartman, Atsushi Ogiwara, C Fattuoni, C Ruttkies, CL Linster, DY Lee, F Allen, Gert Wohlgemuth, GJ Patti, H Sperber, H Tsugawa, H Tsugawa, H Tsugawa, HD Flosadóttir, Hiroshi Tsugawa, I Yamamoto, J Budczies, JG Jeffryes, John Meissen, K Haug, Kohei Takeuchi, M Sud, Masanori Arita, Matthew Mueller, Megan Showalter, MP Styczynski, MR Showalter, O Fiehn, O Fiehn, O Fiehn, O Khersonsky, Oliver Fiehn, Peter Beal, RR da Silva, S Kim, S Kumari, Sajjan Mehta, SE Stein, SM Rappaport, T Kind, Tobias Kind, WR Wikoff, Yuxuan Zheng, Zijuan Lai   +45 more
core   +1 more source

Metformin induces distinct bioenergetic and metabolic profiles in sensitive versus resistant high grade serous ovarian cancer and normal fallopian tube secretory epithelial cells. [PDF]

, 2017
Metformin is a widely used agent for the treatment of diabetes and infertility, however, it has been found to have anti-cancer effects in a variety of malignancies including high grade serous ovarian cancer (HGSC).
Aspuria, Paul-Joseph P, Hodeib, Melissa, Karlan, Beth Y, Lunt, Sophia Y, Ogrodzinski, Martin P, Reue, Karen, Vergnes, Laurent   +6 more
core   +1 more source

Thermodynamics of binding of divalent magnesium and manganese to uridine phosphates: implications for diabetes-related hypomagnesaemia and carbohydrate biocatalysis

Chemistry Central Journal, 2008
Background Although the necessity of divalent magnesium and manganese for full activity of sugar nucleotidyltransferases and glycosyltransferases is well known, the role of these metal cations in binding the substrates (uridine 5'-triphosphate, glucose-1-
Pohl Nicola L, Camci-Unal Gulden, Zea Corbin J   +2 more
doaj   +1 more source

Unnatural Amino Acid and Emerging Chemistry Approaches to Map RNA–Protein Interactions

Angewandte Chemie, EarlyView.
This review highlights emerging chemistries for mapping RNA–protein interactions, including genetically encoded unnatural amino acids, novel photocrosslinkers, and non‐photoactivatable crosslinking systems. We compare their mechanisms, reactivity and applications, outlining how these next‐generation tools enable higher‐resolution, site‐specific ...
Eryn Lundrigan, Parrish Evers, Elexa Scott, John Paul Pezacki   +3 more
wiley   +2 more sources

Glutaredoxin GRXS17 associates with the cytosolic iron-sulfur cluster assembly pathway [PDF]

, 2016
Cytosolic monothiol glutaredoxins (GRXs) are required in iron-sulfur (Fe-S) cluster delivery and iron sensing in yeast and mammals. In plants, it is unclear whether they have similar functions.
Cammue, Bruno PA, De Clercq, Rebecca, De Coninck, Barbara, De Jaeger, Geert, Fernie, Alisdair R, Gevaert, Kris, Goossens, Alain, Iñigo, Sabrina, Klassen, Roland, Le Gall, Sabine, Leidel, Sebastian A, Nagels Durand, Astrid, Pauwels, Laurens, Ritter Traub, Andrés, Schaffrath, Raffael, Termathe, Martin, Tohge, Takayuki, Van Leene, Jelle, Van Lijsebettens, Maria   +18 more
core   +2 more sources

Determination of total potentially available nucleosides in bovine milk [PDF]

, 2010
Bovine colostrum and milk samples were collected from two herds over the course of the first month post-partum, pooled for each herd by stage of lactation and total potentially available nucleosides were determined.
Gill, Brendon D., Indyk, Harvey E., Manley-Harris, Merilyn   +2 more
core   +2 more sources

Age-Dependent Metabolomic Signatures of Dietary Restriction in Mice. [PDF]

Aging Cell
Elevated hepatic glutathione (GSH) and 3‐hydroxybutyrate (3‐HB) levels in all ages of mice demonstrate an enhanced protection against oxidative stress and improvement in energy metabolism during chronic dietary restriction (DR). However, high protein or muscle degradation in liver of young mice, and large accumulation of hepatic glycogen and excessive ...
Lee JS, Arachchige VHJH, Kim EH, Bang E, Hong YS.   +4 more
europepmc   +2 more sources

Baicalin inhibited PANX-1/P2Y6 signaling pathway activation in porcine aortic vascular endothelial cells infected by Glaesserella parasuis

Heliyon
Glaesserella parasuis can induce endothelial barrier damage in piglets, although the mechanism by which this pathogen triggers inflammatory damage remains unclear. Baicalin possesses anti-inflammatory and anti-oxidant activities.
Shulin Fu, Xinyue Tian, Chun Peng, Dan Zhang, Linglu Zhou, Yuzhen Yuan, Jing He, Ling Guo, Yinsheng Qiu, Chun Ye, Yu Liu, Bingbing Zong   +11 more
doaj   +1 more source

A Comparative Study of the Structural Dynamics of Four Terminal Uridylyl Transferases. [PDF]

, 2017
African trypanosomiasis occurs in 36 countries in sub-Saharan Africa with 10,000 reported cases annually. No definitive remedy is currently available and if left untreated, the disease becomes fatal.
Amaro, Rommie E, Cheng, Kevin J, Demir, Özlem   +2 more
core   +1 more source