Interaction of Nucleosides and Related Compounds with Nucleic Acids as Indicated by the Change of Helix-Coil Transition Temperature [PDF]
, 1962 A series of compounds has been tested for effectiveness in lowering the melting temperature of poly A and of thymus DNA. The order of increasing activity was found to be: adonitol, methyl riboside (both negligible) < cyclohexanol < phenol, pyrimidine ...
Helmkamp, G. K. +2 more
core +1 more source
Identifying metabolites by integrating metabolome databases with mass spectrometry cheminformatics. [PDF]
, 2018 Novel metabolites distinct from canonical pathways can be identified through the integration of three cheminformatics tools: BinVestigate, which queries the BinBase gas chromatography-mass spectrometry (GC-MS) metabolome database to match unknowns with ...
A El-Tayeb +45 more
core +1 more source
State-dependent fragmentation of protonated uracil and uridine [PDF]
, 2019 Tandem mass spectroscopy ($\textrm{MS}^2$) combined with single photon excitation in the VUV range (photon energy 4.5-9 eV) was performed on protonated uracil ($\textrm{UraH}^{+}$) and uridine ($\textrm{UrdH}^{+}$). The precursor ions with $m/z\;113$ and $m/z\;245$ respectively were produced by an Electrospray Ionization source (ESI) and accumulated ...
arxiv +1 more source
Sensors, 2016 Zr(IV) can form phosphate and Zr(IV) (–PO32−–Zr4+–) complex owing to the high affinity between Zr(IV) with phosphate. Zr(IV) can induce the aggregation of gold nanoparticles (AuNPs), while adenosine triphosphate(ATP) can prevent Zr(IV)-induced ...
Wenjing Qi +4 more
doaj +1 more source
Nucleotide-, chemotactic peptide- and phorbol ester-induced exocytosis in HL-60 leukemic cells [PDF]
, 1990 Undifferentiated and differentiated HL-60 leukemic cells possess nucleotide receptors which functionally couple to phospholipase C via pertussis toxin-sensitive guanine nucleotide-binding proteins (G-proteins).
Seifert, Roland +1 more
core +1 more source
Coupling of actin hydrolysis and polymerization: Reduced description with two nucleotide states [PDF]
EPL 89, 38010 (2010), 2011 The polymerization of actin filaments is coupled to the hydrolysis of adenosine triphosphate (ATP), which involves both the cleavage of ATP and the release of inorganic phosphate. We describe hydrolysis by a reduced two-state model with a cooperative cleavage mechanism, where the cleavage rate depends on the state of the neighboring actin protomer in a
arxiv +1 more source
Purinergic Receptors of the Central Nervous System: Biology, PET Ligands, and Their Applications
Molecular Imaging, 2020 Purinergic receptors play important roles in central nervous system (CNS). These receptors are involved in cellular neuroinflammatory responses that regulate functions of neurons, microglial and astrocytes.
Hamideh Zarrinmayeh PhD +1 more
doaj +1 more source
Purinergic Signaling in the Hallmarks of Cancer
Cells, 2020 Cancer is a complex expression of an altered state of cellular differentiation associated with severe clinical repercussions. The effort to characterize this pathological entity to understand its underlying mechanisms and visualize potential therapeutic ...
Anaí del Rocío Campos-Contreras +2 more
doaj +1 more source
Renal pericytes: regulators of medullary blood flow [PDF]
, 2012 Regulation of medullary blood flow (MBF) is essential in maintaining normal kidney function. Blood flow to the medulla is supplied by the descending vasa recta (DVR), which arise from the efferent arterioles of juxtamedullary glomeruli.
Agmon Y. +27 more
core +1 more source
A novel RNA pseudouridine site prediction model using Utility Kernel and data-driven parameters [PDF]
arXiv, 2023 RNA protein Interactions (RPIs) play an important role in biological systems. Recently, we have enumerated the RPIs at the residue level and have elucidated the minimum structural unit (MSU) in these interactions to be a stretch of five residues (Nucleotides/amino acids). Pseudouridine is the most frequent modification in RNA. The conversion of uridine
arxiv