Results 71 to 80 of about 120,368 (286)

A circuitous route for in vitro multi-enzyme cascade production of cytidine triphosphate to overcome the thermodynamic bottleneck

Bioresources and Bioprocessing
Cytidine triphosphate (CTP), as a substance involved in the metabolism of phospholipids, proteins and nucleic acids, has precise drug effects and is a direct precursor for the synthesis of drugs such as citicoline.
Zonglin Li, Yahui Zhong, Zhoulei Qing, Zhimin Li   +3 more
doaj   +1 more source

Salvage enzymes in nucleotide biosynthesis [PDF]

, 2007
Balanced pools of deoxyribonucleoside triphosphates (dNTPs), the building blocks of DNA, and ribonucleoside triphosphates (NTPs), the precursors of RNA, are crucial for a controlled cell proliferation.
Kosinska, Urszula
core  

Metformin induces distinct bioenergetic and metabolic profiles in sensitive versus resistant high grade serous ovarian cancer and normal fallopian tube secretory epithelial cells. [PDF]

, 2017
Metformin is a widely used agent for the treatment of diabetes and infertility, however, it has been found to have anti-cancer effects in a variety of malignancies including high grade serous ovarian cancer (HGSC).
Aspuria, Paul-Joseph P, Hodeib, Melissa, Karlan, Beth Y, Lunt, Sophia Y, Ogrodzinski, Martin P, Reue, Karen, Vergnes, Laurent   +6 more
core   +1 more source

Dynamics of Microtubule Instabilities [PDF]

J. Stat. Mech. (2007) L05004, 2007
We investigate the dynamics of an idealized model of microtubule growth that evolves by: (i) attachment of guanosine triphosphate (GTP) at rate lambda, (ii) conversion of GTP to guanosine diphosphate (GDP) at rate 1, and (iii) detachment of GDP at rate mu. As a function of these rates, a microtubule can grow steadily or its length can fluctuate wildly.
arxiv   +1 more source

Integrated Chemoenzymatic Synthesis of the mRNA Vaccine Building Block N1‐Methylpseudouridine Triphosphate

Angewandte Chemie International Edition, Accepted Article.
Pseudouridine‐5’‐triphosphate (ΨTP) and the N1‐methylated derivative (m1ΨTP) are critical monomer building blocks of the currently used mRNA vaccines, yet efficient methods of their synthesis from readily accessible substrates remain underdeveloped. We herein report notably atom‐economic and high‐yielding biocatalytic route toward ΨTP (83% yield) and ...
Martin Pfeiffer, Leo Krammer, Johannes Zöhrer, Rolf Breinbauer, Bernd Nidetzky   +4 more
wiley   +1 more source

A CTP Synthase Undergoing Stage-Specific Spatial Expression Is Essential for the Survival of the Intracellular Parasite Toxoplasma gondii

Frontiers in Cellular and Infection Microbiology, 2018
Cytidine triphosphate synthase catalyzes the synthesis of cytidine 5′-triphosphate (CTP) from uridine 5′-triphosphate (UTP), the final step in the production of cytidine nucleotides.
Heidy Y. Narvaez-Ortiz, Andrea J. Lopez, Nishith Gupta, Barbara H. Zimmermann   +3 more
doaj   +1 more source

Activation of the P2Y2 receptor regulates bone cell function by enhancing ATP release [PDF]

, 2017
Bone cells constitutively release ATP into the extracellular environment where it acts locally via P2 receptors to regulate bone cell function. Whilst P2Y2 receptor stimulation regulates bone mineralisation, the functional effects of this receptor in ...
Arnett, T R, Gueneri, D, Hajjawai, M O, Orriss, I R, Patel, J J, Shaw, K   +5 more
core   +2 more sources

Brownian ratchets driven by asymmetric nucleation of hydrolysis waves [PDF]

Phys. Rev. Lett., 99, 248302, (2007), 2007
We propose a stochastic process wherein molecular transport is mediated by asymmetric nucleation of domains on a one-dimensional substrate. Track-driven mechanisms of molecular transport arise in biophysical applications such as Holliday junction positioning and collagenase processivity.
arxiv   +1 more source

N‐ to C‐Glycoside Rearrangement of Uridine 5′‐Phosphate in Two Enzymatic Steps for the Production of Pseudouridine 5′‐Phosphate

Biotechnology and Bioengineering, EarlyView.
The authors present a streamlined cascade reaction for one‐pot N‐C rearrangement of uridine‐5′‐phosphate (UMP) to pseudouridine‐5′‐phosphate (ΨMP; a key mRNA vaccine building block), in two enzymatic steps catalyzed by UMP nucleosidase (EC 3.2.2.10) and ΨMP C‐glycosidase (EC 4.2.1.70).
Martin Pfeiffer, Franziska Guld, Bernd Nidetzky   +2 more
wiley   +1 more source

The hexosamine biosynthetic pathway rescues lysosomal dysfunction in Parkinson’s disease patient iPSC derived midbrain neurons

Nature Communications
Disrupted glucose metabolism and protein misfolding are key characteristics of age-related neurodegenerative disorders including Parkinson’s disease, however their mechanistic linkage is largely unexplored.
Willayat Y. Wani, Friederike Zunke, Nandkishore R. Belur, Joseph R. Mazzulli   +3 more
doaj   +1 more source