Results 201 to 210 of about 75,542 (296)

Novel DMD Frameshift Variant (p.Leu2017Profs*5) in Spectrin‐Like Repeat 16 Expands the Mutational Spectrum of DMD

Molecular Genetics &Genomic Medicine, Volume 14, Issue 7, July 2026.
A novel DMD frameshift variant (c.6050_6051del; p.Leu2017Profs*5) causes a 2‐bp deletion in exon 42, leading to frameshift, premature truncation, and disruption of spectrin‐like repeat 16 architecture. ABSTRACT Background Duchenne muscular dystrophy (DMD) is an X‐linked neuromuscular disorder caused by pathogenic variants in the DMD gene, which encodes
Yu‐Chin Lin, G. W. Gant Luxton, Hwei‐Jen Lee, Yu‐Yang Lu, Hung‐Chi Yang, Kuo‐Sheng Hung, Ming‐Tsong Lai, Chih‐Fen Hu   +7 more
wiley   +1 more source

Nitrite Dipstick Urinalysis as a Point-Of-Care Test for Sodium Nitrite Poisoning. [PDF]

Ther Drug Monit
Bethlehem C, Vleut IT, Augustijn D, Michielse J, Limmen R, Verweij JL, Dekker D, Koch BCP, Hassanzai M.   +8 more
europepmc   +1 more source

Granulosa Cell Tumour in a Spayed Cat With Ovarian Remnant Syndrome and Hyperestrogenaemia Without Estrus Signs

Veterinary Medicine and Science, Volume 12, Issue 4, July 2026.
Granulosa cell tumour arising from ovarian remnant tissue can occur in spayed cats without overt estrus signs, despite marked hyperestrogenaemia. In this case, CT showed a large abdominal mass contiguous with ovarian vasculature; surgery and histopathology confirmed granulosa cell tumour with hepatic metastasis.
Hitomi Shinoda, Kenji Mori, Hiroshi Mori, Kumiko Ishigaki, Kazushi Asano   +4 more
wiley   +1 more source

Genomic and Sex Contributions to Interindividual Variability in Pitavastatin Bioavailability

Basic &Clinical Pharmacology &Toxicology, Volume 139, Issue 1, July 2026.
ABSTRACT Aim This study investigates pharmacogenetic determinants of pitavastatin disposition using a candidate‐gene approach. Methods In 48 healthy volunteers, 138 variants across 40 genes involved in drug metabolism and transport were analysed to assess their relationship with pitavastatin pharmacokinetics, alongside the influence of sex and ...
Eva González‐Iglesias, Sofía Moreno‐Pérez de Villar, Dolores Ochoa, Manuel Román, Jesús Novalbos, Samuel Martín‐Vilchez, Alejandro de Miguel, Francisco Abad‐Santos   +7 more
wiley   +1 more source

Analytical validation, reference interval determination, and diagnostic performance of plasma symmetric dimethylarginine in cattle. [PDF]

J Vet Intern Med
De Campos C, Barroca IBN, Baydoun Z, Chenal T, Gonçalves-Brandão M, Schelcher F, Trumel C.   +6 more
europepmc   +1 more source

Efficacy and Safety of Lianhua Qingke Tablets in Children With Mycoplasma pneumoniae Pneumonia: A Randomized, Double‐Blind, Multicenter, Placebo‐Controlled Clinical Trial

The Clinical Respiratory Journal, Volume 20, Issue 7, July 2026.
In this randomized, double‐blind, placebo‐controlled trial involving 160 children with mild Mycoplasma pneumoniae pneumonia, adding Lianhua Qingke tablets to conventional therapy significantly improved symptom resolution by Day 7 (85.9% vs. 65.6%) and shortened median recovery time (4.5 vs.
He Wang, Haiwei Dou, Guangying Chen, Yanmin Wei, Hua Li, Shuqiong Xu, Rongzhen Kang, Shanhong Liu, Long Zhang, Nan Li, Hongli Sun, Chi Wang, Jie Zhao, Jirong Yi, Wentao Song, Hongrong Li, Rong Ma, Kunling Shen, Deli Xin, Wenjie Qi   +19 more
wiley   +1 more source

Prescribing Patterns and Treatment Persistence for Overactive Bladder in Japan Across Medical Specialties and Facility Types: A Nationwide Claims Database Study. [PDF]

Int J Urol
Omae K, Hashimoto K, Maeda S.
europepmc   +1 more source

A Phase 1, Open‐Label, Randomized Study to Investigate the Pharmacokinetics and Safety of Multiple Doses of Intranasal Naloxone in Healthy Participants

Clinical and Translational Science, Volume 19, Issue 7, July 2026.
ABSTRACT This was a Phase 1, open label, randomized, crossover study to evaluate the safety and pharmacokinetics of multiple doses of intranasal naloxone (NCT05377255). Twenty‐four healthy participants were enrolled at a single site in the US to one of two sequences.
David Cassie, Bob Warnock, Faisal Akhtar, Duncan McCloskey, David Wyatt   +4 more
wiley   +1 more source

XGBoost (eXtreme Gradient Boosting) Can Predict Organisms Growing in Urine Culture from the Emergency Department. [PDF]

West J Emerg Med
Sheele JM, Campbell RL, Jones DD.
europepmc   +1 more source

Drug Interactions of Vebreltinib, a Novel Type I c‐Met Inhibitor, Coadministration With Rifampin or Itraconazole in Healthy Participants

Clinical and Translational Science, Volume 19, Issue 7, July 2026.
Pharmacokinetic and drug–drug interaction evaluation of vebreltinib in healthy participants, showing decreased exposure with rifampin and increased exposure with itraconazole. ABSTRACT Vebreltinib is a novel, highly selective type I c‐Met inhibitor developed for treating non–small cell lung cancer (NSCLC) and glioma.
Jingcheng Chen, Jingxuan Wu, Yuqin Song, Jiangshuo Li, Linna li, Lijun Li, Yanhong Kong, Xiaofang Wu, Hang Yin, Mengyu Hou, Bingyan Wang, Qiannan Gao, Ran Li, Le Wu, Weizhe Xue, Ruihua Dong   +15 more
wiley   +1 more source