Results 111 to 120 of about 269,394 (298)

Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Multiple Ascending Doses and Dose Titration of Bexicaserin in Healthy Participants in a Randomized, Double‐Blind, Placebo‐Controlled Study

Clinical Pharmacology in Drug Development, EarlyView.
Abstract Bexicaserin (LP352) is a selective superagonist of the 5‐hydroxytryptamine 2C (5‐HT2C) receptor currently in development for the treatment of seizures that arise from developmental and epileptic encephalopathies. This phase 1, double‐blind, placebo‐controlled multiple ascending dose (MAD) study assessed the safety, tolerability, and ...
Jonathan Williams, Rosa Chan, Chad Orevillo, Gale O'Connell, Dewey McLin, Shikha Polega, Nuggehally R. Srinivas, Randall Kaye   +7 more
wiley   +1 more source

THE TREATMENT OF PAPILLARY TUMORS OF THE URINARY BLADDER WITH THE HIGH-FREQUENCY CURRENT (OUDIN)

, 1912
Edwin Beer
openalex   +2 more sources

PharmVar GeneFocus: NAT2—Genetic Variation and Updated Nomenclature

Clinical Pharmacology &Therapeutics, EarlyView.
The Pharmacogene Variation Consortium (PharmVar) provides nomenclature for the highly polymorphic human N‐acetyltransferase 2 (NAT2) gene. NAT2 metabolizes several clinically used drugs including isoniazid, hydralazine, amifampridine, procainamide, and sulfonamides such as dapsone, and also some highly carcinogenic arylamines.
Georgia Papanikolaou, Estella S. Poloni, José A.G. Agúndez, Raquel L.F. Teixeira, Erin C. Boone, Adalberto Rezende Santos, Michelle Whirl‐Carrillo, Katrin Sangkuhl, Teri E. Klein, Mariam R. Habil, Giannoulis Fakis, Rodney F. Minchin, David W. Hein, Sotiria Boukouvala, Andrea Gaedigk   +14 more
wiley   +1 more source

Neurohypophyseal Hormone-Sensitive Adenyl Cyclase of Toad Urinary Bladder

, 1970
Hans‐Peter Bär, Oscar Hechter, Irving L. Schwartz, Roderich Walter   +3 more
openalex   +2 more sources

Effect of Recombinant Human Keratinocyte Growth Factor (rHuKGF, Palifermin) on Radiation-Induced Mouse Urinary Bladder Dysfunction [PDF]

, 2005
Jana Jaal, W. Doerr
openalex   +1 more source

Practice of Cytopathology in Korea: A 40‐Year Evolution Through Standardization, Digital Transformation, and Global Partnership

Diagnostic Cytopathology, EarlyView.
ABSTRACT Over four decades, Korea has advanced from a limited cytology service to a global model of digital and AI‐integrated cytopathology. Since the founding of the Korean Society for Cytopathology (KSC) in 1986, a nationwide framework has been established—encompassing standardized practices, systematic education for specialists and cytotechnologists,
Yosep Chong, Ran Hong, Hyeong Ju Kwon, Haeryoung Kim, Lucia Kim, Soon Jae Kim, Yoon Jung Choi   +6 more
wiley   +1 more source

DIRECT VISUAL OBSERVATION OF THE CONTRACTION OF THE URINARY BLADDER AND URETHRA DURING STIMULATING PELVIC NERVE, HYPOGASTRIC NERVE AND PUDENDAL NERVE ELECTRICALLY

, 1981
Takashi Morita, Hideaki Saeki, Ikuo Wada, Shigeki Matsuo, Osamu Nishizawa, Seigi Tsuchida   +5 more
openalex   +2 more sources

Streptozotocin induced hyperglycemia in the axolotl

Developmental Dynamics, EarlyView.
Abstract Background Diabetes is a group of diseases characterized by loss of β cell mass and/or function, resulting in hyperglycemia. With no established curative treatment, this has initiated research in β cell regeneration. Current animal models have either limited regenerative capacity (mice) or small size and evolutionary distance from humans ...
Pernille Lajer Sørensen, Anita Dittrich, Henrik Lauridsen   +2 more
wiley   +1 more source

Intra-Abdominal Hemorrhage Due to Spontaneous Urinary Bladder Diverticulum Rupture in a Female: An Autopsy Case Report and Brief Review of the Literature

Forensic Sciences
Urinary bladder diverticula are formed by the herniation of the mucosa into the muscle layer of the bladder wall, often ending with a narrow neck that communicates with the bladder lumen.
Ioannis Ketsekioulafis, Konstantinos Katsos, Dimitrios Kouzos, Dimitrios Vlachodimitropoulos, Nikolaos Goutas, Chara Spiliopoulou, Emmanouil I. Sakelliadis   +6 more
doaj   +1 more source

Calcitonin gene‐related peptide concentration in cerebrospinal fluid and serum in horses affected by trigeminal‐mediated headshaking

Equine Veterinary Journal, EarlyView.
Abstract Background Trigeminal‐mediated headshaking (TMHS) in horses shares clinical features with human trigeminal neuralgia (HTN). Increased levels of the neuropeptide calcitonin gene‐related peptide (CGRP) have been found in the blood and cerebrospinal fluid (CSF) of HTN patients. Inhibition of CGRP in humans has shown promise for pain relief.
Lisa Annabel Weber, Hilke Oltmanns, Ludovica Chiavaccini, Kirstie J. Pickles, Veronica Roberts, Tanja Kloock, Tobias Niebuhr, Karsten Feige   +7 more
wiley   +1 more source