Results 181 to 190 of about 1,327,983 (335)

Injectable Genetic Engineering Hydrogel for Promoting Spatial Tolerance of Transplanted Kidney in Situ

open access: yesAdvanced Science
The establishment of a tolerant space to realize the co‐stimulation of cytokines and contact‐dependent molecules remain challenging in allotransplant.
Jinwen Lin   +7 more
doaj   +1 more source

Genomic sequencing has a high diagnostic yield in children with congenital anomalies of the heart and urinary system. [PDF]

open access: yesFront Pediatr, 2023
Allred ET   +5 more
europepmc   +1 more source

Screening and Identification of Novel DNA Aptamer for Targeted Delivery to Injured Podocytes in Glomerular Diseases

open access: yesAdvanced Science, EarlyView.
This study develops RLS‐2, a high‐affinity aptamer that specifically targets injured podocytes, making it a promising candidate for targeted drug delivery. In vitro, RLS‐2 shows stability, specificity, efficient siRNA delivery via AsiCs, and uptake by podocytes.
Chao Zhou   +9 more
wiley   +1 more source

Integrative Multi‐Omics and Routine Blood Analysis Using Deep Learning: Cost‐Effective Early Prediction of Chronic Disease Risks

open access: yesAdvanced Science, EarlyView.
Omicsformer, a deep learning model, integrates multi‐omics and routine blood data to accurately predict risks for nine chronic diseases, including cancer and cardiovascular conditions. Validated using large scale clinical data, it reveals early risk trajectories, advancing personalized medicine and offering a cost‐effective, community‐based solution ...
Zhibin Dong   +20 more
wiley   +1 more source

Enhanced efficacy of immune checkpoint inhibitors by folate-targeted multifunctional drug through synergistic therapy inducing ferroptosis and immunogenic cell death in bladder cancer

open access: yesMaterials Today Bio
Purpose: The research aims to elucidate the anti-tumor mechanism of the composite multifunctional folate-targeted drug DIFP-FA through sonodynamic therapy (SDT), chemodynamic therapy (CDT), and chemotherapy, as well as its potential to augment immune ...
Yibo Shi   +10 more
doaj  

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