Results 21 to 30 of about 544,439 (228)

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

FEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake, Yuki Enoki, Yuka Nakazawa, Kazuaki Taguchi, Kazuaki Matsumoto   +4 more
wiley   +1 more source

Unraveling the role of gut microbiota by fecal microbiota transplantation in rat model of kidney stone disease

Scientific Reports
Emerging research on the microbiome highlights the significant role of gut health in the development of kidney stones, indicating that an imbalance in gut bacteria or dysbiosis can influence the formation of stones by altering oxalate metabolism and ...
Sittiphong Hunthai, Manint Usawachintachit, Mana Taweevisit, Monpichar Srisa-Art, Weerapat Anegkamol, Piyaratana Tosukhowong, Pakkapon Rattanachaisit, Natthaya Chuaypen, Thasinas Dissayabutra   +8 more
doaj   +1 more source

STXBP3 and GOT2 predict immunological activity in acute allograft rejection

Frontiers in Immunology, 2022
BackgroundAcute allograft rejection (AR) following renal transplantation contributes to chronic rejection and allograft dysfunction. The current diagnosis of AR remains dependent on renal allograft biopsy which cannot immediately detect renal allograft ...
Qinfan Yao, Qinfan Yao, Qinfan Yao, Qinfan Yao, Cuili Wang, Cuili Wang, Cuili Wang, Cuili Wang, Yucheng Wang, Yucheng Wang, Yucheng Wang, Yucheng Wang, Wenyu Xiang, Wenyu Xiang, Wenyu Xiang, Wenyu Xiang, Yin Chen, Yin Chen, Yin Chen, Yin Chen, Qin Zhou, Qin Zhou, Qin Zhou, Qin Zhou, Jianghua Chen, Jianghua Chen, Jianghua Chen, Jianghua Chen, Hong Jiang, Hong Jiang, Hong Jiang, Hong Jiang, Dajin Chen, Dajin Chen, Dajin Chen, Dajin Chen   +35 more
doaj   +1 more source

Quantitative proteomic analysis reveals different characteristics of bladder cancer cells after exposure to bisphenol A

FEBS Open Bio, EarlyView.
Bisphenol A (BPA), a common chemical in plastics, exerts dual effects on bladder cancer cells: low doses promote growth and migration, while high doses suppress growth and migration. Multi‐omics and bioinformatics reveal BPA acts via MAPK and inflammatory pathways.
Shaomin Niu, Lanlan Li, Wenjuan Jia, Hanzhong Feng, Xiaoquan Yu, Youli Zhao, Fengzhi Yuan, Hui Ding, Junqiang Tian, Yong‐Xing He, Zhiping Wang   +10 more
wiley   +1 more source

Development and preclinical evaluation of a novel FGFR3-targeted antibody-drug conjugate in bladder cancer

Asian Journal of Pharmaceutical Sciences
Given the critical shortage of antibody-drug conjugates (ADCs) for bladder cancer (BCa), we developed a novel FGFR3-targeted ADC, LZU-WZLYFG001, composed of a humanized anti-FGFR3 IgG1 monoclonal antibody, a cleavable GGFG linker, and the payload DXD ...
Guangrui Fan, Xiongfei Luo, Kun Li, Ze Zhang, Chaohu Chen, Yibo Shi, Shu Cui, Yingru Wang, Dengtuo Wang, Zhijun Zhang, Zhilong Dong, Junqiang Tian, Liang Cheng, Juan Wang, Zhenxing Zhai, Yingqian Liu, Zhiping Wang   +16 more
doaj   +1 more source

Role of Age-Related Changes in DNA Methylation in the Disproportionate Susceptibility and Worse Outcomes of Sepsis in Older Adults

Frontiers in Medicine, 2022
Sepsis, a complex multisystem disorder, is among the top causes of hospitalization and mortality in older adults. However, the mechanisms underlying the disproportionate susceptibility to sepsis and worse outcomes in the elderly are not well understood ...
Xiabing Lang, Xiabing Lang, Xiabing Lang, Xiabing Lang, Lingling Shen, Lingling Shen, Lingling Shen, Lingling Shen, Tingting Zhu, Tingting Zhu, Tingting Zhu, Tingting Zhu, Wenjun Zhao, Wenjun Zhao, Wenjun Zhao, Wenjun Zhao, Yang Chen, Yang Chen, Yang Chen, Yang Chen, Chaohong Zhu, Chaohong Zhu, Chaohong Zhu, Chaohong Zhu, Qun Su, Cuili Wang, Cuili Wang, Cuili Wang, Cuili Wang, Yucheng Wang, Yucheng Wang, Yucheng Wang, Yucheng Wang, Francesco Neri, Hong Jiang, Hong Jiang, Hong Jiang, Hong Jiang, Jianghua Chen, Jianghua Chen, Jianghua Chen, Jianghua Chen   +41 more
doaj   +1 more source

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source

Evodiamine induces ferroptosis in prostate cancer cells by inhibiting TRIM26-mediated stabilization of GPX4

Chinese Medicine
Background Prostate cancer is a major global health challenge, characterized by high morbidity and mortality rates. Traditional treatment options, including androgen deprivation therapy and chemotherapy, often lead to drug resistance.
Lanlan Li, Jianzhong Lu, Shengjun Fu, Wenyan Li, Ying Wang, Ke Wang, Yan Tao, Shanhui Liu   +7 more
doaj   +1 more source

Frailty Exacerbates Disability in Progressive Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background To evaluate frailty in severe progressive multiple sclerosis (PMS) and to investigate the underlying mechanisms. Methods This prospective, cross‐sectional, multicenter study enrolled a late severe PMS group requiring skilled nursing (n = 53) and an age, sex, and disease duration‐matched control PMS group (n = 53).
Taylor R. Wicks, Anna Wolska, Diala Ghazal, Dejan Jakimovski, Bianca Weinstock‐Guttman, Alexander Burnham, Niels Bergsland, Michael G. Dwyer, Alan T. Remaley, Robert Zivadinov, Murali Ramanathan   +10 more
wiley   +1 more source

USP7 promotes chemotherapy resistance and DNA damage response through stabilizing and deubiquitinating KDM4A in bladder cancer

Cell Death and Disease
Bladder cancer is a common malignancy, and the insensitivity of advanced bladder cancer to cisplatin poses an imminent challenge to treatment. Our study aims to identify novel targets that mediate cisplatin responsiveness in bladder cancer.
Hailang Yang, Xiaoqiang Liu, Jianqiang Nie, Shuwei Wu, Li Ma, Yi Jiang, Lizhi Zhou, Wen Deng, Qianxi Dong, Situ Xiong, Sheng Li, Fuchun Zheng, An Xie, Songhui Xu, Bin Fu   +14 more
doaj   +1 more source