Results 21 to 30 of about 541,110 (246)

Comparison of laparoscopic and robot-assisted partial nephrectomy for intermediate/high-complexity endophytic renal tumors (R.E.N.A.L.-NS ≥ 7): a propensity score-matched retrospective study

BMC Cancer
Purpose To compare operative, functional, and oncological outcomes between laparoscopic partial nephrectomy (LPN) and robot-assisted partial nephrectomy (RAPN) for intermediate/high-complexity (R.E.N.A.L.
Luyao Chen, Sheng Li, Fuchun Zheng, Zhongqi Li, Ruize Yuan, Ming Jiang, Yue Gao, Yanping Song, Bin Fu, Lizhi Zhou, Situ Xiong, Jiangxi Li, Jin Zeng   +12 more
doaj   +1 more source

STXBP3 and GOT2 predict immunological activity in acute allograft rejection

Frontiers in Immunology, 2022
BackgroundAcute allograft rejection (AR) following renal transplantation contributes to chronic rejection and allograft dysfunction. The current diagnosis of AR remains dependent on renal allograft biopsy which cannot immediately detect renal allograft ...
Qinfan Yao, Qinfan Yao, Qinfan Yao, Qinfan Yao, Cuili Wang, Cuili Wang, Cuili Wang, Cuili Wang, Yucheng Wang, Yucheng Wang, Yucheng Wang, Yucheng Wang, Wenyu Xiang, Wenyu Xiang, Wenyu Xiang, Wenyu Xiang, Yin Chen, Yin Chen, Yin Chen, Yin Chen, Qin Zhou, Qin Zhou, Qin Zhou, Qin Zhou, Jianghua Chen, Jianghua Chen, Jianghua Chen, Jianghua Chen, Hong Jiang, Hong Jiang, Hong Jiang, Hong Jiang, Dajin Chen, Dajin Chen, Dajin Chen, Dajin Chen   +35 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Role of Age-Related Changes in DNA Methylation in the Disproportionate Susceptibility and Worse Outcomes of Sepsis in Older Adults

Frontiers in Medicine, 2022
Sepsis, a complex multisystem disorder, is among the top causes of hospitalization and mortality in older adults. However, the mechanisms underlying the disproportionate susceptibility to sepsis and worse outcomes in the elderly are not well understood ...
Xiabing Lang, Xiabing Lang, Xiabing Lang, Xiabing Lang, Lingling Shen, Lingling Shen, Lingling Shen, Lingling Shen, Tingting Zhu, Tingting Zhu, Tingting Zhu, Tingting Zhu, Wenjun Zhao, Wenjun Zhao, Wenjun Zhao, Wenjun Zhao, Yang Chen, Yang Chen, Yang Chen, Yang Chen, Chaohong Zhu, Chaohong Zhu, Chaohong Zhu, Chaohong Zhu, Qun Su, Cuili Wang, Cuili Wang, Cuili Wang, Cuili Wang, Yucheng Wang, Yucheng Wang, Yucheng Wang, Yucheng Wang, Francesco Neri, Hong Jiang, Hong Jiang, Hong Jiang, Hong Jiang, Jianghua Chen, Jianghua Chen, Jianghua Chen, Jianghua Chen   +41 more
doaj   +1 more source

Microfluidic electro‐viscoelastic manipulation of extracellular vesicles

FEBS Open Bio, EarlyView.
The electro‐viscoelastic manipulation as a potential method for separation of particles based on size. The particles introduced as a sheath flow migrate to the channel center under the influence of simultaneously applied electric field and pressure driven flow.
Seyedamirhosein Abdorahimzadeh, Éva Bozó, Zikrullah Bölükkaya, Artem Zhyvolozhnyi, Anatoliy Samoylenko, Henrikki Liimatainen, Seppo J. Vainio, Caglar Elbuken   +7 more
wiley   +1 more source

Unraveling the role of gut microbiota by fecal microbiota transplantation in rat model of kidney stone disease

Scientific Reports
Emerging research on the microbiome highlights the significant role of gut health in the development of kidney stones, indicating that an imbalance in gut bacteria or dysbiosis can influence the formation of stones by altering oxalate metabolism and ...
Sittiphong Hunthai, Manint Usawachintachit, Mana Taweevisit, Monpichar Srisa-Art, Weerapat Anegkamol, Piyaratana Tosukhowong, Pakkapon Rattanachaisit, Natthaya Chuaypen, Thasinas Dissayabutra   +8 more
doaj   +1 more source

Development and preclinical evaluation of a novel FGFR3-targeted antibody-drug conjugate in bladder cancer

Asian Journal of Pharmaceutical Sciences
Given the critical shortage of antibody-drug conjugates (ADCs) for bladder cancer (BCa), we developed a novel FGFR3-targeted ADC, LZU-WZLYFG001, composed of a humanized anti-FGFR3 IgG1 monoclonal antibody, a cleavable GGFG linker, and the payload DXD ...
Guangrui Fan, Xiongfei Luo, Kun Li, Ze Zhang, Chaohu Chen, Yibo Shi, Shu Cui, Yingru Wang, Dengtuo Wang, Zhijun Zhang, Zhilong Dong, Junqiang Tian, Liang Cheng, Juan Wang, Zhenxing Zhai, Yingqian Liu, Zhiping Wang   +16 more
doaj   +1 more source

Pre-transplant Transcriptional Signature in Peripheral Blood Mononuclear Cells of Acute Renal Allograft Rejection

Frontiers in Medicine, 2022
Acute rejection (AR) is closely associated with renal allograft dysfunction. Here, we utilised RNA sequencing (RNA-Seq) and bioinformatic methods to characterise the peripheral blood mononuclear cells (PBMCs) of patients with acute renal allograft ...
Wenyu Xiang, Wenyu Xiang, Wenyu Xiang, Wenyu Xiang, Shuai Han, Shuai Han, Shuai Han, Shuai Han, Cuili Wang, Cuili Wang, Cuili Wang, Cuili Wang, Hongjun Chen, Hongjun Chen, Hongjun Chen, Hongjun Chen, Lingling Shen, Lingling Shen, Lingling Shen, Lingling Shen, Tingting Zhu, Tingting Zhu, Tingting Zhu, Tingting Zhu, Kai Wang, Wenjie Wei, Jing Qin, Nelli Shushakova, Song Rong, Hermann Haller, Hong Jiang, Hong Jiang, Hong Jiang, Hong Jiang, Jianghua Chen, Jianghua Chen, Jianghua Chen, Jianghua Chen   +37 more
doaj   +1 more source

Diabetes‐induced vascular calcification is associated with low pyrophosphate and its oral supplementation prevents calcification in diabetic mice

FEBS Open Bio, EarlyView.
Induction of diabetes in three different mouse strains uniformly resulted in an increase in TNAP activity and a reduction in pyrophosphate (PPi) in the circulation. Inhibition of TNAP restored plasma PPi. Diabetes‐induced calcification in the media layer of the aorta was detected only in the Abcc6−/− strain, which is predisposed to ectopic ...
Krisztina Fülöp, Eszter Kozák, Natália Tőkési, Lilian Kocsis, Anikó Kelemen, Zsuzsanna Geszti, Adriána Kutás, Mariann Harangi, Ágnes Diószegi, Zsolt Rapi, József Balla, Olivier Le Saux, András Váradi, Viola Pomozi   +13 more
wiley   +1 more source

Risk analysis of enfortumab vedotin: A real-world approach based on the FAERS database

Heliyon
Purpose: To analyze the risk of enfortumab vedotin (EV), a targeted therapy for advanced bladder cancer, using real-world data from the U.S. Food and Drug Administration's Federal Adverse Event Reporting System (FAERS).
Fuchun Zheng, Yuanzhuo Du, Yuyang Yuan, Zhipeng Wang, Sheng Li, Situ Xiong, Jin Zeng, Yifan Tan, Xiaoqiang Liu, Songhui Xu, Bin Fu, Wei Liu   +11 more
doaj   +1 more source