Results 31 to 40 of about 561,554 (159)

LncRNA MALAT1 facilitates BM-MSCs differentiation into endothelial cells and ameliorates erectile dysfunction via the miR-206/CDC42/PAK1/paxillin signalling axis

Reproductive Biology and Endocrinology
Background Erectile dysfunction (ED) is a common male sexual dysfunction, with an increasing incidence, and the current treatment is often ineffective. Methods Vascular endothelial growth factor (VEGFA) was used to treat bone marrow-derived mesenchymal ...
Longhua Luo, Zixin Wang, Xuxian Tong, Tenxian Xiong, Minggen Chen, Xiang Liu, Cong Peng, Xiang Sun   +7 more
doaj   +1 more source

Targeting the FTO-ACSL4 Pathway: A Novel Mechanism for Sanguinarine Chloride-Induced Ferroptosis in Endometrial Cancer

Biomedicines
Objective: Endometrial cancer (EC) remains a significant clinical challenge, particularly for patients with advanced or recurrent disease. This study aims to investigate the effects of Sanguinarine Chloride (S.C), a natural benzophenanthridine alkaloid ...
Wenyan Li, Shanhui Liu, Ke Wang, Jianzhong Lu, Shengjun Fu, Lanlan Li, Yan Tao   +6 more
doaj   +1 more source

Effect of finerenone on proteinuria reduction in IgA nephropathy

Renal Failure
Background Recent studies have suggested a protective effect of finerenone on renal function and reduced the risk of cardiovascular events in patients with CKD and type 2 diabetes. However, its role in IgA nephropathy remains unknown. This study aimed to
Guizhen Yu, Meifang Wang, Xue Zhang, Juan Tao, Jie Zhao, Shanshan Liu, Suhan Zhou, Jingyi Zhou, Pingping Ren, Jun Cheng, Jianghua Chen   +10 more
doaj   +1 more source

A Novel FGFR3‐Targeting Antibody‐Drug Conjugate Induces Tumor Cell Apoptosis through the cGAS–STING Pathway in Bladder Cancer

Advanced Science
Antibody‐drug conjugates (ADCs) emerge as a potent cancer therapeutic strategy by enabling precise antigen recognition and efficient intracellular delivery of cytotoxic payloads. In this study, 7‐ethyl‐9‐fluorocamptothecin (A2), a camptothecin derivative,
Shu Cui, Xiongfei Luo, Guangrui Fan, Jingqi Jiang, Yingru Wang, Enguang Yang, Jinpeng Ma, Ze Zhang, Yuhan Wang, Juan Wang, Dengtuo Wang, Hanzhang Wang, Liang Cheng, Junqiang Tian, Zhilong Dong, Yingqian Liu, Zhiping Wang   +16 more
doaj   +1 more source

The clinical efficacy of novel semirigid ureteroscopy with a vacuum suction device for treatment of >10 mm upper ureteral stones and impacted calculus: implications for clinical practice

Frontiers in Surgery
ObjectiveThe novel semirigid ureteroscopy with a vacuum suction device has been increasing in the treatment of urinary stones recently. This study aimed to evaluate its clinical efficacy for treating >10 mm upper ureteral stones and impacted calculus ...
Longhui Lai, Longhui Lai, Yuanfeng Zhang, Yuanfeng Zhang, Yingru Wang, Enguang Yang, Guangrui Fan, Chaohu Chen, Kang Yao, Wenzhao Zhang, Wenzhao Zhang, Yongfei Liu, Yongfei Liu, Kai Zhu, Kai Zhu, Meixuan Ding, Meixuan Ding, Jinchun Xing, Zhiping Wang, Peide Bai, Tao Wang, Bin Chen, Jun Mi   +22 more
doaj   +1 more source

Current perspectives and trends on the role of mitochondria in renal ischemia-reperfusion injury from 2005 to 2024: a bibliometric analysis and literature review

Frontiers in Physiology
BackgroundRenal ischemia-reperfusion injury (RIRI) represents a leading cause of acute kidney injury (AKI). Mitochondria, serving as the central organelles for cellular energy metabolism and signal transduction, play a pivotal role in the pathogenesis of
Rui Yan, Rui Yan, Rui Yan, Yalong Zhang, Yalong Zhang, Yalong Zhang, Zewen Li, Zewen Li, Zewen Li, Kunpeng Li, Kunpeng Li, Kunpeng Li, Jiangwei Man, Jiangwei Man, Jiangwei Man, Li Yang, Li Yang, Li Yang   +17 more
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Pelvic vasectomy and its protective effects on rat testis function

Basic and Clinical Andrology
Background Vasectomy is a commonly used male contraceptive method, but the choice of surgical technique can influence long-term reproductive health outcomes.
Heng Yang, Yujun Chen, Xiaofeng Cheng, Jingxin Wu, Ruohui Huang, Biao Qian, Gongxian Wang   +6 more
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A novel sono-activatable nanoreactor induces precision intratumoral juglone generation and caspase 3/GSDME-mediated pyroptosis for treatment of bladder cancer

Journal of Nanobiotechnology
Background Juglone, a natural naphthoquinone compound, exhibits potent anticancer activity but faces clinical limitations due to poor solubility, low bioavailability, and systemic toxicity.
Yuanfeng Zhang , Enguang Yang, Xinyu Zhang , Yibo Shi , Guangrui Fan, Yuhan Wang, Junqiang Tian, Hanzhang Wang, Zhilong Dong, Yingru Wang, Liang Cheng, Zhiwen Zhao, Yonghai Zhang, Baodui Wang, Zhiping Wang   +14 more
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AGBL2 promotes renal cell carcinoma cells proliferation and migration via α-tubulin detyrosination

Heliyon
Background: AGBL2's role in tumorigenesis and cancer progression has been reported in several cancer studies, and it is closely associated with α-tubulin detyrosination.
Wei Liu, Yifei Zhang, Yechen Nie, Yifu Liu, Zhongqi Li, Zhicheng Zhang, Binbin Gong, Ming Ma   +7 more
doaj   +1 more source

Anoikis-related genes predicts prognosis and therapeutic response in renal cell carcinoma

Annals of Medicine
Background Metastasis represents the primary cause of cancer-related mortality, with a high incidence observed in renal cell carcinoma (RCC). Anoikis, a specialized form of apoptosis, plays a crucial role in preventing displaced cells from adhering to ...
Lizhi Zhou, Hengcheng Lu, Bin Fu, Jianhan Fu   +3 more
doaj   +1 more source