Results 21 to 30 of about 866,426 (291)

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

Loss of RNF41 promotes bladder cancer metastasis through increasing NUDC stability to enhance tubulin polymerization

Cell Death and Disease
Bladder cancer (BCa) is a representative of urological cancer with a high recurrence and metastasis is the leading cause of death from BCa. The underlying mechanism of BCa metastasis remains poorly defined.
Fuchun Zheng, Sheng Li, Situ Xiong, Zhongqi Li, Ruize Yuan, Zhipeng Wang, Hao Wan, Jiahao Liu, Qianxi Dong, Xiaoqiang Liu, Wan Pang, Haibo Xi, Bin Fu, Songhui Xu   +13 more
doaj   +1 more source

Multi-omics dissection of fatty acid metabolism heterogeneity identifies PRDX1 as a prognostic marker in bladder cancer

Frontiers in Immunology
BackgroundFatty−acid metabolism (FAM) is rewired in bladder cancer (BLCA), yet its impact on intratumoral diversity and patient outcome is unclear.MethodsTo characterize FAM heterogeneity, we integrated spatial and single-cell transcriptomic approaches ...
Li Wang, Li Wang, Zhe Chang, Zhe Chang, Si-yu Chen, Si-yu Chen, Jian-wei Yang, Jian-wei Yang, Kang-yu Wang, Kang-yu Wang, Kun-peng Li, Kun-peng Li, Shun Wan, Shun Wan, Shan hui Liu, Shan hui Liu, Li Yang, Li Yang   +17 more
doaj   +1 more source

Association Between BAK1 Gene rs210138 Polymorphisms and Testicular Germ Cell Tumors: A Systematic Review and Meta-Analysis

Frontiers in Endocrinology, 2020
Background: Several studies including some genome-wide association studies (GWAS) had shown that BAK1 gene rs210138 polymorphisms might be associated with testicular germ cell tumors (TGCT).
Jiaxuan Qin, Jiaxuan Qin, Jiaxuan Qin, Yufeng Yang, Yufeng Yang, Yufeng Yang, Xuan Zhuang, Xuan Zhuang, Xuan Zhuang, Jinchun Xing, Jinchun Xing, Jinchun Xing   +11 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Exploring the shared genetic architecture between leukocyte telomere length and renal cell carcinoma: a cross-trait analysis

Discover Oncology
Background While epidemiological studies suggest an association between leukocyte telomere length (LTL) and renal cell carcinoma (RCC), the genetic basis underlying this relationship remains to be elucidated.
Li Wang, Jian-wei Yang, Kang-yu Wang, Si-yu Chen, Li Yang   +4 more
doaj   +1 more source

Brain metastasis from prostate cancer with neurologic symptoms as the first sign: a case report

The Aging Male
Background Prostate cancer most commonly metastasizes to bones and lymph nodes; visceral metastases are uncommon. Central nervous system involvement is exceedingly rare. Here, we report a case of prostate cancer with brain metastasis initially presenting
Chuanjian Chen, Chunhao Mo, Shaolong Zhang, Youming Shi, Luhua Ji, Zhongyun Ning, Hui Ding   +6 more
doaj   +1 more source

The risk factors and predictive model for cardiac valve calcification in patients on maintenance peritoneal dialysis: a single-center retrospective study

Renal Failure, 2023
Background Cardiovascular calcification includes cardiac valve calcification (CVC) and vascular calcification. We aimed to analyze risk factors for CVC, and construct a predictive model in maintenance peritoneal dialysis (MPD) patients.Methods We ...
Yuxi Wang, Quanquan Shen, Junni Wang, Shilong Xiang, Yaomin Wang, Xiaohui Zhang, Jianghua Chen, Fei Han   +7 more
doaj   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

No ureteral catheter mini percutaneous nephrolithotomy (NUC-mPCNL) achieves enhanced recovery after surgery (ERAS)

Scientific Reports
Conventional mini percutaneous nephrolithotomy (mPCNL) typically necessitates the pre-operative placement of ureteral catheters. With the development of enhanced recovery after surgery (ERAS), we introduce a novel approach: no ureteral catheter mini ...
Xuwen Li, Zhongyu Tan, Yue Yu, Xiaochen Zhou, Haibo Xi, Wei Liu   +5 more
doaj   +1 more source