Results 21 to 30 of about 561,554 (159)

Risk analysis of enfortumab vedotin: A real-world approach based on the FAERS database

Heliyon
Purpose: To analyze the risk of enfortumab vedotin (EV), a targeted therapy for advanced bladder cancer, using real-world data from the U.S. Food and Drug Administration's Federal Adverse Event Reporting System (FAERS).
Fuchun Zheng, Yuanzhuo Du, Yuyang Yuan, Zhipeng Wang, Sheng Li, Situ Xiong, Jin Zeng, Yifan Tan, Xiaoqiang Liu, Songhui Xu, Bin Fu, Wei Liu   +11 more
doaj   +1 more source

Evodiamine induces ferroptosis in prostate cancer cells by inhibiting TRIM26-mediated stabilization of GPX4

Chinese Medicine
Background Prostate cancer is a major global health challenge, characterized by high morbidity and mortality rates. Traditional treatment options, including androgen deprivation therapy and chemotherapy, often lead to drug resistance.
Lanlan Li, Jianzhong Lu, Shengjun Fu, Wenyan Li, Ying Wang, Ke Wang, Yan Tao, Shanhui Liu   +7 more
doaj   +1 more source

Ubiquitination regulates autophagy in cancer: simple modifications, promising targets

Journal of Translational Medicine
Autophagy is an important lysosomal degradation process that digests and recycles bio-molecules, protein or lipid aggregates, organelles, and invaded pathogens.
Yihui Wu, Yifei Chen, Xianyan Tian, Genbao Shao, Qiong Lin, Aiqin Sun   +5 more
doaj   +1 more source

The application of genetic testing technology in kidney transplantation: precision matching, non-invasive monitoring and personalized management

Frontiers in Immunology
Kidney transplantation remains the treatment of choice for patients with end-stage renal disease, yet its long-term success continues to face major challenges, including organ shortage, rejection, and drug toxicity.
Yalong Zhang, Yalong Zhang, Hao Wang, Hao Wang, Rui Yan, Rui Yan, Kangyu Wang, Kangyu Wang, Jiangwei Man, Jiangwei Man, Li Yang, Li Yang   +11 more
doaj   +1 more source

Research advances on the urinary microbiome in non-infectious urinary tract diseases: from community composition to clinical prospects

Frontiers in Cellular and Infection Microbiology
IntroductionWith the rapid development of 16S rRNA sequencing and metagenomic technologies, the traditional concept of sterile urine has been completely overturned, and a diverse urinary microbiome has been identified even in healthy individuals ...
Yalong Zhang, Yalong Zhang, Hao Wang, Hao Wang, Rui Yan, Rui Yan, Kangyu Wang, Kangyu Wang, Jiangwei Man, Jiangwei Man, Li Yang, Li Yang   +11 more
doaj   +1 more source

Autophagy-related biological targets and network mechanisms of juglone against bladder cancer

Journal of Cancer Research and Clinical Oncology
Objective This study aimed to explore juglone’s mechanism in inducing autophagy and apoptosis in bladder cancer (BLCA) via network pharmacology and experimental validation.
Yuanfeng Zhang, Enguang Yang, Xinyu Zhang, Ze Zhang, Guoxin Huang, Baoyuan Tang, Chaohu Chen, Longhui Lai, Zixu Pei, Yonghai Zhang, Zhiping Wang   +10 more
doaj   +1 more source

PA-MSHA improves prognosis of patients undergoing radical cystectomy: a retrospective cohort study using inverse probability of treatment weighting

Frontiers in Immunology
ObjectiveTo observe the effect of Pseudomonas aeruginosa mannose-sensitive hemagglutinin (PA-MSHA) on the prognosis and the incidence of lymphatic leakage in patients undergoing radical cystectomy (RC).MethodA total of 129 patients who underwent RC in ...
Xiaohua Zhang, Zixu Pei, Jinglei Ren, Jing Shi, Wenjun Lu, Yuan Shui, Wentao Ma, Luyang Zhang, Hui Ding, Yunxin Zhang, Junqiang Tian, Zhiping Wang   +11 more
doaj   +1 more source

TRIM28 drives immune evasion via PARP1 SUMOylation and NAD+ depletion in clear cell renal cell carcinoma

Journal for ImmunoTherapy of Cancer
Background Immune checkpoint blockade (ICB) therapy has demonstrated significant clinical potential in a variety of cancers; however, its efficacy in clear cell renal cell carcinoma (ccRCC) remains suboptimal.
Yang Liu, Jing Xiong, Xiangpeng Zhan, Hongji Hu, Hao Wan, Fuchun Zheng, Luyao Chen, Xiaoqiang Liu, Xingang Cui, Songhui Xu, Bin Fu   +10 more
doaj   +1 more source

Synbiotics as a novel therapeutic approach for hyperphosphatemia and hyperparathyroidism in chronic kidney disease rats

Scientific Reports
Hyperphosphatemia and secondary hyperparathyroidism (SHPT) are the common complications found in CKD that lead to severe complications including mineral bone disease (MBD), vascular calcification (VC), and cardiovascular mortality.
Weerapat Anegkamol, Wirin Bowonsomsarit, Mana Taweevisit, Somying Tumwasorn, Thana Thongsricome, Maroot Kaewwongse, Rath Pitchyangkura, Piyaratana Tosukhowong, Natthaya Chuaypen, Thasinas Dissayabutra   +9 more
doaj   +1 more source

Evolving paradigms in prostate cancer screening: a decade of bibliometric insights and technological advancements

Frontiers in Oncology
ObjectiveProstate cancer is a major threat to global male health. This study uses bibliometric methods to analyze the dynamics and trends in prostate cancer screening research, with the aim of optimizing screening strategies and informing policy ...
Keqiang Chai, Changhong Xu, Jiangwei Man, Yun Deng, Li Yang   +4 more
doaj   +1 more source