Results 51 to 60 of about 866,426 (291)

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source

Evodiamine induces ferroptosis in prostate cancer cells by inhibiting TRIM26-mediated stabilization of GPX4

Chinese Medicine
Background Prostate cancer is a major global health challenge, characterized by high morbidity and mortality rates. Traditional treatment options, including androgen deprivation therapy and chemotherapy, often lead to drug resistance.
Lanlan Li, Jianzhong Lu, Shengjun Fu, Wenyan Li, Ying Wang, Ke Wang, Yan Tao, Shanhui Liu   +7 more
doaj   +1 more source

Conservative interventions for urinary incontinence in women: an overview of Cochrane systematic reviews [PDF]

, 2016
This is the protocol for a review and there is no abstract. The objectives are as follows:  To synthesise Cochrane reviews of conservative interventions, as described above, for the prevention or treatment of female urinary incontinence.Output Type ...
Alewijnse, Alewijnse, Alhasso, Alves, Amaro, Balshem, Bastian, Berkman, Blaivas, Bogner, Bump, Bø, Cadwell, Carriere, Chaimani, Chang, Chiarelli, Clement, Cody, Dean, Dumoulin, Duthie, Eustice, Ford, Francis, French, Glazener, Glazener, Godec, Groat, Groat, Groutz, Guyatt, Guyatt, Guyatt, Guyatt, Guyatt, Guyatt, Guyatt, Hajebrahimi, Haylen, Herbison, Hunskaar, Hunskaar, Imamura, Islah, Jackson, Kelleher, Kirchin, Komesu, Lapitan, Lipp, MacArthur, McClurg, Melville, Messelink, Milsom, Morrill, Morrison, Ostaszkiewicz, Ostaszkiewicz, Palmer, Perry, Pollock, Rai, Rehman, Sandvik, Sandweiss, Shinohara, Smith, Takahashi, Thom, Turner, Wagner, Wallace, Wang, Whitford, Wilks, Wilson, Yau   +79 more
core   +3 more sources

Cognitive Status in People With Epilepsy in the Republic of Guinea: A Prospective, Case–Control Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective People with epilepsy (PWE) may experience cognitive deficits but fail to undergo formal evaluation. This study compares cognitive status between PWE and healthy controls in the West African Republic of Guinea. Methods A cross‐sectional, case–control study was conducted in sequential recruitment phases (July 2024–July 2025) at Ignace ...
Maya L. Mastick, Cheick O. Soumah, Malé Doré, Oumar Mara, Desiré Neldje, Fodé A. Cissé, Toure M. Lamine, Aminata Diallo, Seungwon Lee, Siddharth Satish, Alexander J. X. Chen, Alice Liu, Nomin Enkhtsetseg, Farrah J. Mateen, The Guinea Epilepsy Project   +14 more
wiley   +1 more source

Urinary proteomics can define distinct diagnostic inflammatory arthritis subgroups [PDF]

, 2017
Current diagnostic tests applied to inflammatory arthritis lack the necessary specificity to appropriately categorise patients. There is a need for novel approaches to classify patients with these conditions.
Gaya, Daniel, Hampson, Rosie, Latosinska, Agnieszka, McInnes, Iain, Mischak, Harald, Mullen, William, Paterson, Caron, Porter, Duncan, Schanstra, Joost, Siebert, Stefan   +9 more
core   +2 more sources

In‐Depth Profiling Highlights the Effect of Efgartigimod on Peripheral Innate and Adaptive Immune Cells in Myasthenia Gravis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Myasthenia gravis (MG) is an autoimmune disorder characterized by antibody‐mediated complement activation. Efgartigimod, a neonatal Fc receptor (FcRn) antagonist, is approved for treating generalized MG (gMG). However, its modulatory effects on upstream innate and adaptive immune cells remain largely unexplored.
Lei Jin, Liu Dong, Ying Wang, Dingxian He, Chong Yan, Jianying Xi, Haoqin Jiang, Yu Shi, Ming Guan, Chongbo Zhao, Jie Song, Sushan Luo   +11 more
wiley   +1 more source

Ubiquitination regulates autophagy in cancer: simple modifications, promising targets

Journal of Translational Medicine
Autophagy is an important lysosomal degradation process that digests and recycles bio-molecules, protein or lipid aggregates, organelles, and invaded pathogens.
Yihui Wu, Yifei Chen, Xianyan Tian, Genbao Shao, Qiong Lin, Aiqin Sun   +5 more
doaj   +1 more source

The application of genetic testing technology in kidney transplantation: precision matching, non-invasive monitoring and personalized management

Frontiers in Immunology
Kidney transplantation remains the treatment of choice for patients with end-stage renal disease, yet its long-term success continues to face major challenges, including organ shortage, rejection, and drug toxicity.
Yalong Zhang, Yalong Zhang, Hao Wang, Hao Wang, Rui Yan, Rui Yan, Kangyu Wang, Kangyu Wang, Jiangwei Man, Jiangwei Man, Li Yang, Li Yang   +11 more
doaj   +1 more source

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi, Lara Basovic, Christopher Michael McGraw   +2 more
wiley   +1 more source

Research advances on the urinary microbiome in non-infectious urinary tract diseases: from community composition to clinical prospects

Frontiers in Cellular and Infection Microbiology
IntroductionWith the rapid development of 16S rRNA sequencing and metagenomic technologies, the traditional concept of sterile urine has been completely overturned, and a diverse urinary microbiome has been identified even in healthy individuals ...
Yalong Zhang, Yalong Zhang, Hao Wang, Hao Wang, Rui Yan, Rui Yan, Kangyu Wang, Kangyu Wang, Jiangwei Man, Jiangwei Man, Li Yang, Li Yang   +11 more
doaj   +1 more source