Results 161 to 170 of about 1,044,595 (309)

QUALITY CHARACTERISTICS OF COCONUT WATER AND ITS EFFECT ON HUMAN SUBJECTS

Food and Environment Safety
Coconut water, the clear liquid extracted from coconuts (Cocos nucifera L.), is a refreshing tropical drink with a booming market. However, despite its success, the moisturizing properties of this product remain controversial.
Ekoua Regina KRABI, Koffi Maïzan Jean-Paul BOUATENIN, Yabo Majoie Géroxie TOHOYESSOU, Lydia Karell KOKOLA, Semassa Josiane ADJOBIGNON, Wahauwouélé Hermann COULIBALY, Fatoumata CAMARA, Marina KOUSSEMON, Sébastien NIAMKÉ   +8 more
doaj  

Defect‐Engineered BiO2‐X Nanosheets Mediate Sono‐Thermomechanical ECM Remodeling for Hepatocellular Carcinoma Immunotherapy

Advanced Science, EarlyView.
Herein, an ultrasound‐responsive BiO2‐X/siFn1 nanoplatform is developed to overcome anti‐PD‐1 resistance in hepatocellular carcinoma. Upon ultrasound irradiation, the platform downregulates fibronectin expression, while its sonothermal effect softens the dense extracellular matrix and activates antitumor immunity in the tumor microenvironment, thereby ...
Huimin Tian, Shen Zhang, Bolin Wu, Yichi Chen, Haitao Shang, Haoyan Tan, Chunyue Wang, Weichen Xu, Huixiong Xu, Haohao Yin, Wen Cheng   +10 more
wiley   +1 more source

Detection and Excretion Profile of Retatrutide in Human Plasma and Urine by LC-HRMS: Implications for Antidoping Analysis. [PDF]

Rapid Commun Mass Spectrom
Carneiro GRA, da Costa Nunes IK, Dos Santos Cardoso GR, Dos Santos PF, Padilha MC, Nogueira FCS, Pereira HMG.   +6 more
europepmc   +1 more source

OAF Blocks SIAH1‐Mediated Degradation of SCPX, a Therapeutic Strategy for MASLD

Advanced Science, EarlyView.
This study shows OAF directly binds to SCPX and inhibits its interaction with the E3 ligase SIAH1, thereby protecting SCPX from ubiquitin‐dependent degradation and stabilizing its levels. This OAF‐SCPX axis represents a novel pathway in lipid homeostasis, highlighting OAF as a promising therapeutic candidate for MASLD.
Zongxi Li, Jingyue Song, Kaili Ma, Shunan Tang, Shuqian Wang, Wenya Ji, Chen Lu, Ting Zhang, Huaping Zheng, Xiaowei Zheng, Shanshan Lai, Cheng Deng   +11 more
wiley   +1 more source

Recalibrating the urine output criteria for acute kidney injury: stage-specific thresholds matched to creatinine-stage-derived mortality. [PDF]

Crit Care
Tenhunen AB, Mossberg R, Lipcsey M, Eriksson M, Marks-Hultström M.   +4 more
europepmc   +1 more source

Silver nanoparticles promote osteogenic differentiation of human urine-derived stem cells at noncytotoxic concentrations

, 2014
Hui Qin,1,* Chen Zhu,2,* Zhiquan An,1 Yao Jiang,1 Yaochao Zhao,1 Jiaxin Wang,1 Xin Liu,1 Bing Hui,1 Xianlong Zhang,1 Yang Wang1 1Department of Orthopedics, Sixth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai ...
Jiang Y, Liu X, Hui B, Zhang X, Qin H, An Z, Wang Y, Wang J, Zhao Y, Zhu C   +9 more
core  

Natural Product Toosendanin Suppresses the Malignant Development of Skin Melanoma by Targeting BNC2 for Degradation

Advanced Science, EarlyView.
BNC2 exhibits context‐dependent opposing functions across multiple cancer types. This study reveals BNC2 as an oncogenic driver of melanoma proliferation and metastasis through transcriptional activation of PIK3CA. The natural compound TSN simultaneously degrades BNC2 and its oncogenic partner SMAD3 via CRBN‐dependent ubiquitination.
Hui Dai, Xin Mei Zhang, Jing Cheng Zhang, Xu Ting Deng, Qiao Liu, Mustafa Hussein Ali, Fang Zhou Yin, Wu Yin   +7 more
wiley   +1 more source

Association Between Urine pH and Kidney Outcomes in Patients with Biopsy-Proven Kidney Disease. [PDF]

Diagnostics (Basel)
Tsuji K, Uchida N, Nakanoh H, Inoue Y, Fukushima K, Kitamura S, Wada J.   +6 more
europepmc   +1 more source

Design and Application of Nanozymes: Current Trends and Cutting‐Edge Breakthroughs

Advanced Science, EarlyView.
Kelong Fan, Hui Wei, Xiyun Yan
wiley   +1 more source

AARS1‐Mediated H3K27 Lactylation Rewires Glycolysis to Sustain Aggressive and Recurrent Bladder Cancer

Advanced Science, EarlyView.
AARS1 drives PI3K–AKT–mTOR‐dependent glycolysis in bladder cancer, promoting lactate accumulation, increased lactylation, H3K27la enrichment at the HK2 promoter, and HK2 transcription. HK2 reinforces glycolysis, sustaining a metabolic–epigenetic program associated with tumor progression, recurrence, and metastasis.
Qin Yuan, Tianbao Song, Yipeng He, Sihan Xia, Yaoqiu Huang, Wenlin He, Qin Yi, Zefeng Wang, Peihan Wang, Chenbo Huang, Linzhi Li, Zhen Yin, Fan Cheng, Weimin Yu   +13 more
wiley   +1 more source