Results 71 to 80 of about 99 (99)
Advanced Science, EarlyView.A tumor‐targeted, renal‐metabolized, and less O2‐dependent Type‐I photosensitizer is presented for photodynamic therapy of tumors. The formation of an intramolecular sandwich‐like π–π assembly ensures its rigid orthogonal geometry, thereby improving the superoxide (O2•−)‐generating ability, promoting the intracellular formation of hydroxy radical (HO•),
Guangxiao Yao +3 more
wiley +1 more source
Epidemiology of occupational injuries in construction workers between 2009 and 2018 in South Korea
American Journal of Industrial Medicine, Volume 66, Issue 2, Page 155-166, February 2023., 2023 Abstract Background This study aimed to investigate the characteristics of occupational injuries based on fatality, sex, and classification of occupations among construction workers using workers' compensation (WC) insurance data in South Korea. Methods We collected WC insurance data from the Korea Workers' Compensation & Welfare Service for all ...
Saemi Jung +5 more
wiley +1 more source
Plac1+ Tumor Cell‐Treg Interplay Supports Tumorigenesis and Progression of Head and Neck Cancer
Advanced Science, EarlyView.Meng et al. screen genes in the CTAs family and find Plac1 is specifically expressed in head and neck squamous cell carcinoma (HNSCC) cells. They reveal that Plac1 expression promotes HNSCC progression directly by activating PI3K/AKT signaling pathway.
Xiaoyan Meng +8 more
wiley +1 more source
Two SOX11 variants cause Coffin–Siris syndrome with a new feature of sensorineural hearing loss
American Journal of Medical Genetics Part A, Volume 191, Issue 1, Page 183-189, January 2023., 2023 Abstract Coffin‐Siris syndrome (CSS, OMIM#135900) is a rare congenital disorder associated with neurodevelopmental and dysmorphic features. The primary cause of CSS is pathogenic variants in any of 9 BAF chromatin‐remodeling complex encoding genes or the genes SOX11 and PHF6. Herein, we performed whole‐exome sequencing (WES) and a series of analyses of
Qiuquan Wang +5 more
wiley +1 more source
Advanced Science, EarlyView.Slippery‐adhesive Janus gel dressing exhibits both stable tissue adhesive and outstanding efficiency in repelling physiological fluids. As a physical barrier, a liquid‐infused surface with a dynamic lubrication overlayer possesses excellent antibiofouling properties, making it highly effective in preventing bacterial infections and postoperative tissue
Yuan Gao +14 more
wiley +1 more source
Further characterization of NFIB‐associated phenotypes: Report of two new individuals
American Journal of Medical Genetics Part A, Volume 191, Issue 2, Page 540-545, February 2023., 2023 Abstract Nuclear Factor I B (NFIB) haploinsufficiency has recently been identified as a cause of intellectual disability (ID) and macrocephaly. Here we report on two new individuals carrying a microdeletion in the chromosomal region 9p23‐p22.3 containing NFIB.
Gemma Marinella +8 more
wiley +1 more source
Advanced Science, EarlyView.In this study, Merkoçi and his research group present a polymer‐based synthesis to enhance the stability of Prussian blue (PB) nanoparticles. The resulting PB‐infused catalytic hetero‐interface architecture (PB‐CHIA) achieves complete two‐dimensional (2D) and three‐dimensional (3D) substrate coverage (glassy carbon and laser‐induced graphene electrodes)
Sinan Uzunçar +3 more
wiley +1 more source
Advanced Science, EarlyView.This study uncovers that CD38high monocytes discriminate sepsis and sterile inflammation and are associated with 28‐day mortality in bacterial sepsis. Targeting CD38 therapy reduces inflammatory response in monocytes and in sepsis mice model. Mechanistically, CD38‐HIF‐1α/glycolysis/MGO loop exacerbates sepsis‐induced immune dysregulation.
Ning Hua +19 more
wiley +1 more source
Calpain‐2‐Mediated Endothelial Focal Adhesion Disruption in Thoracic Aortic Dissection
Advanced Science, EarlyView.The elevated expression of Capn2 in endothelial cells activates focal adhesion signaling by cleaving Talin1 and assembling Itgav, which compromises the integrity of the endothelial barrier and induces vascular inflammation. Inhibition of calpain through both pharmacological and transgenic approaches has effectively suppressed the onset and progression ...
Xiaomei Teng +10 more
wiley +1 more source
Advanced Science, EarlyView.Oral squamous cell carcinoma cells exhibit upregulated expression of GSDMD upon exposure to low‐dose cisplatin chemotherapy, which subsequently interacts with MMP14 through its N‐terminal domain, activating the epithelial‒mesenchymal transition (EMT) process and promoting the lymph node metastasis of oral squamous cell carcinoma.
Zixian Huang +9 more
wiley +1 more source