Results 81 to 90 of about 99 (99)

Therapeutic Potential of Lipid Nanoparticle‐Encapsulated CD19‐Targeting mRNAs in Lupus and Rheumatoid Arthritis

Advanced Science, EarlyView.
This study develops lipid nanoparticle‐encapsulated mRNA‐encoding antibodies (mRNab‐LNPs) targeting CD19, demonstrating robust anti‐CD19 antibody production in vivo. Intramuscular injection of mRNab‐LNPs reduces CD19+ B and plasma cells in lupus and rheumatoid arthritis mice, significantly alleviating histopathological changes and tissue injuries of ...
Chipeng Guo, Yingsen Tang, Ling Zeng, Xiaomei You, Siweier Luo, Yufei Du, Le Wang, Liangchun Wang, Jianchuan Wang, Jinjin Chen, Yiming Zhou   +10 more
wiley   +1 more source

Self‐Propelled In Situ Polymerized Nanoparticles Activating the STING Pathway for Enhanced Bladder Cancer Immunotherapy

Advanced Science, EarlyView.
A self‐propelled nanomedicine delivery system forms DMCU nanoparticles in the bladder via in situ polymerization of dopamine hydrochloride, Mn2+, cGAMP, and urease. The urease‐driven propulsion enhances retention and drug delivery. These nanoparticles activate the STING pathway, stimulating dendritic cells and T cells to boost anti‐bladder cancer ...
Lei Peng, Anguo Zhao, Rongkang Li, Yujun Liu, Daitian Tang, Dashi Deng, Qi Zhuang, Rui Liang, Shaohua Zhang, Song Wu   +9 more
wiley   +1 more source

A Transient Photoelectric Spiking Neuron Based on a Highly Robust MgO Composite Threshold Switching Memristor for Selective UV Perception

Advanced Electronic Materials, EarlyView.
The artificial UV photoelectric spiking neuron baesd on the LIF circuit is built by integrating a physically transient TS device and an UV photodetector. Artificial photoelectric spiking neuron can selectively detect UV stimuli and encode them into electrical spikes, compensating for this deficiency of human vision and promising for implantable optical
Yaxiong Cao, Rui Wang, Saisai Wang, Tonglong Zeng, Wanlin Zhang, Jing Sun, Xiaohua Ma, Hong Wang, Yue Hao   +8 more
wiley   +1 more source

Recent Advances in Enhancing the Sensitivity of Biosensors Based on Field Effect Transistors

Advanced Electronic Materials, EarlyView.
This paper discusses the methods to enhancing the detection sensitivity of biosensors in three aspects: overcoming the influence of Debye shielding effects, promoting the binding efficiency of analytes and transistor surface, and improving the structures of device.
Yuying Zhou, Tongshi Feng, Yao Li, Xiang Ao, Shengfa Liang, Xiaonan Yang, Lingfei Wang, Xiaoxin Xu, Wenchang Zhang   +8 more
wiley   +1 more source

Effect of autonomic nervous system resection extent on urinary dysfunction in robotic rectal cancer surgery

Annals of Gastroenterological Surgery, EarlyView.
In rectal cancer surgery, this study examined the risk factors for urinary dysfunction and the effect of autonomic nervous system resection extent on urinary dysfunction. Autonomic nervous system resection and lateral lymph node dissection were independent risk factors for urinary dysfunction.
Sodai Arai, Hiroyasu Kagawa, Akio Shiomi, Yusuke Yamaoka, Shoichi Manabe, Chikara Maeda, Yusuke Tanaka, Shunsuke Kasai, Akifumi Notsu, Yusuke Kinugasa   +9 more
wiley   +1 more source

Possibility of incorrect evaluation of intraoperative blood loss during open and laparoscopic distal pancreatectomy

Annals of Gastroenterological Surgery, EarlyView.
This study showed that estimated BL (e‐BL) was significantly greater than intraoperative BL(i‐BL) in cases of laparoscopic distal pancreatectomy (LDP), and that e‐BL was significantly less than i‐BL in cases of open DP (ODP), only among patients with pancreatic cancer.
Keisuke Toya, Yoshito Tomimaru, Shogo Kobayashi, Kazuki Sasaki, Yoshifumi Iwagami, Daisaku Yamada, Takehiro Noda, Hidenori Takahashi, Yuichiro Doki, Hidetoshi Eguchi   +9 more
wiley   +1 more source

Optimal duration of antimicrobial prophylaxis in patients undergoing distal pancreatectomy: A multicenter cohort study

Annals of Gastroenterological Surgery, EarlyView.
Prolonged administration of antimicrobial prophylaxis might not be effective to prevent surgical site infections after distal pancreatectomy compared to intraoperative or up to 24‐h administration. Abstract Background Antimicrobial prophylaxis is routinely administered in patients undergoing distal pancreatectomy, with cephalosporins being the most ...
Kenjiro Okada, Kenichiro Uemura, Sohei Satoi, Tsutomu Fujii, Manabu Kawai, So Yamaki, Toru Watanabe, Hideki Motobayashi, Shinya Takahashi   +8 more
wiley   +1 more source

Reoperative pouch surgery for suspected Crohn's‐related complications aided by biologic coverage: Early experience from an inflammatory bowel disease center

Annals of Gastroenterological Surgery, EarlyView.
This paper demonstrates that revisional/redo ileal pouch anal anastomosis (IPAA) surgery with concurrent biologic therapy provides a viable, stoma‐free alternative for patients with Crohn's disease‐like complications, showing a high functioning pouch rate and expanding options for managing pouch failure.
Mehmet Gulmez, Daniel J. Wong, Ariela K. Holmer, Eren Esen, Shannon Chang, Arman Erkan, David Hudesman, Andre da Luz Moreira, Feza H. Remzi   +8 more
wiley   +1 more source

Enhancing SDT Efficacy of Doxorubicin‐Loaded Sonosensitizer Micelles to Overcome Resistance of Cancer Therapy by Optimizing Acoustic Parameters

Aggregate, EarlyView.
The study reveals that optimizing various parameters of sonodynamic therapy (SDT), including the functional characteristics of sonosensitizers and the optimization of acoustic parameters, can significantly enhance SDT therapeutic efficacy. When combined with chemotherapy, this approach effectively overcomes tumor resistance and induces antitumor immune
Zhuoran Gong, Deshang Hou, Yunxue Xu, Mengxuan Wang, Shiyin Lin, Yingjuan Zheng, Zhifei Dai   +6 more
wiley   +1 more source

Harnessing Aggregation‐Induced Emission‐Based Detection Toolbox for Diagnostics of Urogenital Tumors

Aggregate, EarlyView.
This review provides a comprehensive overview of recent advancements in aggregation‐induced emission (AIE) biosensors for the diagnosis of urogenital system tumors, encompassing prostate, cervical, bladder, and ovarian cancers. Furthermore, it examines the various types of AIE biosensors utilized in biomarker detection, cell fluorescence imaging ...
Wenzhe Chen, Hantian Guan, Yongfeng Lu, Guohua Zeng, Di Gu, Keying Guo, Cheng Jiang, Hongxing Liu   +7 more
wiley   +1 more source