Results 81 to 90 of about 1,288,316 (295)

Clustering Algorithm Reveals Dopamine‐Motor Mismatch in Cognitively Preserved Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To explore the relationship between dopaminergic denervation and motor impairment in two de novo Parkinson's disease (PD) cohorts. Methods n = 249 PD patients from Parkinson's Progression Markers Initiative (PPMI) and n = 84 from an external clinical cohort.
Rachele Malito, Chiara Meneghini, Alice Galli, Luca Gallo, Pierfrancesco Mitrotti, Paola Dimartino, Marianna Inglese, Cinzia Zatti, Alessandro Lupini, Andrea Pilotto, Alessandro Padovani, Micol Avenali, Enza Maria Valente, Cristina Tassorelli, Silvia P. Caminiti   +14 more
wiley   +1 more source

Amperometric Biosensor for Oxalate Determination in Urine Using Sequential Injection Analysis

Molecules, 2012
An amperometric flow biosensor for oxalate determination in urine samples after enzymatic reaction with oxalate oxidase immobilized on a modified magnetic solid is described.
Enrique Barrado, Yolanda Castrillejo, Veronica Salazar, Prisciliano Hernandez, Jose A. Rodriguez   +4 more
doaj   +1 more source

Photonic crystal based biosensor for the detection of glucose concentration in urine

, 2017
Photonic sensing technology is a new and accurate measurement technology for bio-sensing applications. In this paper, a two-dimensional photonic crystal ring resonator based sensor is proposed and designed to detect the glucose concentration in urine ...
S. Robinson, Nagaraj Dhanlaksmi
semanticscholar   +1 more source

CX3CL1 in Early Detection of Alzheimer's Disease: Plasma Dynamics Across Age and Disease Stages

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Backgrounds Alzheimer's disease (AD) is characterized by amyloid‐beta plaques, tau tangles, and neuroinflammation. C‐X3‐C motif chemokine ligand 1 (CX3CL1, also known as fractalkine), a neuroimmune chemokine implicated in AD pathogenesis, shows inconsistent alterations in plasma/serum across studies.
Ling Wang, Yujie Liu, Fei Li, Xuelin Li, Lanlan Li, Jie Zhang, Yali Xu   +6 more
wiley   +1 more source

Clinical Validation of Plasma p‐217tau in Neurological Diseases

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Plasma p‐217tau is a minimally invasive but specific biomarker for diagnosing Alzheimer's disease (AD). However, its disease specificity remains to be clinically evaluated. We validated the reliability of the p‐217tau biomarker in 12 other neurological diseases.
Takeshi Kawarabayashi, Takumi Nakamura, Ryoma Takahashi, Tetsuya Ueda, Seiji Kinoshita, Chikage Uchida, Takashi Sugawara, Kentaro Hashimoto, Kunihiko Ishizawa, Masakuni Amari, Hiroo Kasahara, Yoshio Ikeda, Masamitsu Takatama, Mikio Shoji   +13 more
wiley   +1 more source

Influence of Freezing and Storage Procedure on Human Urine Samples in NMR-Based Metabolomics

Metabolites, 2013
It is consensus in the metabolomics community that standardized protocols should be followed for sample handling, storage and analysis, as it is of utmost importance to maintain constant measurement conditions to identify subtle biological differences ...
Burkhard Luy, Bernhard Watzl, Stefan Heissler, Achim Bub, Manuela J. Rist, Benjamin Görling, Claudia Muhle-Goll   +6 more
doaj   +1 more source

Serum Soluble Mediator Signatures of Lupus Nephritis: Histologic Features and Response to Treatment

Arthritis Care &Research, EarlyView.
Objective Lupus nephritis (LN) management remains challenging, and novel noninvasive biomarkers are needed. This study quantified serum soluble mediators in the Accelerating Medicines Partnership (AMP) LN cohort to identify biomarkers of histologic features and treatment response.
Andrea Fava, Catriona A. Wagner, Carla J. Guthridge, Susan Macwana, Wade DeJager, Melissa E. Munroe, Peter Izmirly, H. Michael Belmont, Betty Diamond, Anne Davidson, Paul J. Utz, Michael H. Weisman, Philip M. Carlucci, Maria Dall'Era, Kenneth Kalunian, Chaim Putterman, Jennifer Anolik, Jennifer L. Barnas, David Wofsy, Diane Kamen, Richard A. Furie, Deepak A. Rao, the Accelerating Medicines Partnership Rheumatoid Arthritis and Systemic Lupus Erythematosus Network, Chun‐Hao Lee, Derek Fine, Manny Monroy‐Trujillo, Ummara Shah, Mariko Ishimori, Robert M. Clancy, Michael Belmont, Ming Wu, Nicole Bornkamp, Evan Der, Beatrice Goilav, Nicole Jordan, Daniel Schwartz, James Pullman, David Wofsy, Dawn Smilek, Patti Tosta, Matthias Kretzler, Celine C. Berthier, E. Steve Woodle, Dave Hildeman, Michael Brenner, Michelle Petri, Joel M. Guthridge, Jill Buyon, Judith A. James   +48 more
wiley   +1 more source

Examining intraindividual variability of urinary gluten immunogenic peptides compared to the lactulose-mannitol ratio in healthy volunteers: implications for clinical assessment of intestinal permeability

Frontiers in Immunology
IntroductionThe intestinal barrier plays a crucial role in preventing the translocation of harmful substances. Intestinal permeability is commonly assessed using the lactulose-mannitol ratio (LMR) test, which measures absorption of non-metabolizable ...
Raquel Rodríguez-Ramírez, Raquel Rodríguez-Ramírez, María Auxiliadora Fernández Peralbo, Ángel Cebolla, Carolina Sousa   +4 more
doaj   +1 more source

Serum activities of liver enzymes in workers exposed to sub-TLV levels of dimethylformamide

International Journal of Occupational Medicine and Environmental Health, 2015
Objectives: The aim of this study has been to investigate serum activities of liver enzymes in workers exposed to sub-TLV levels of dimethylformamide (DMF). Material and Methods: Seventy-two workers and 72 healthy controls participated in the study.
Jinjiang He, Jie Liu, Yulin Kong, Weiwei Yang, Zengli Zhang   +4 more
doaj   +1 more source

Environmental Chemicals in Urine and Blood: Improving Methods for Creatinine and Lipid Adjustment

Environmental Health Perspectives, 2015
Background Investigators measuring exposure biomarkers in urine typically adjust for creatinine to account for dilution-dependent sample variation in urine concentrations.
K. O’Brien, K. Upson, N. Cook, C. Weinberg   +3 more
semanticscholar   +1 more source