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A comparative analysis of serial measurements of Soluble Urokinase-type Plasminogen Activator Receptor (suPAR) and C-reactive protein in patients with moderate COVID-19: a single center study from India

, 2022
Kakar A, Rani P, Batra T, Hasan R, Choudhury S.   +4 more
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The murine urokinase-type plasminogen activator gene

Biochemistry, 1987
The murine urokinase-type plasminogen activator (uPA) gene has been isolated from a BALB/c liver DNA cosmid library and its nucleotide sequence established. The gene is organized into 11 exons comprising 34.7% of the 6710 base pair (bp) region spanning the interval between the presumed transcription initiation and polyadenylation sites.
Jay L. Degen, Janice L. Heckel, E. Reich, Sandra J. Friezner Degen   +3 more
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Expression of urokinase‐type plasminogen activator, urokinase‐type plasminogen activator receptor, and plasminogen activator inhibitor‐1 and ‐2 in hepatocellular carcinoma

Pathology International, 2000
It has become more and more clear in recent decades that the plasminogen activation system, which includes urokinase‐type plasminogen activator (uPA), urokinase‐type plasminogen activator receptor (uPAR), plasminogen activator inhibitor (PAI)‐1 and PAI‐2, plays a very important role in the aggressiveness of cancer. Using immunohistochemistry and enzyme‐
Weiping Wang, Yoshitake Hayashi, Takashi Itoh, Li Zhou, Jing an Rui, Hiroshi Itoh   +5 more
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Modulation of lipoxidase activity by urokinase-type plasminogen activator

Prostaglandins, Leukotrienes and Essential Fatty Acids, 1994
Malignant cells show increased urokinase (UK) activity and decreased peroxidation of essential fatty acids (EFA). In order to explore this phenomenon the effect of UK on the lipoxidase activity was spectrophotometrically investigated. Decreased lipoxidase activity was obtained with increased UK concentrations (r = -1.000, p < 0.0001).
P.J. Du Toit, D. J. Du Plessis, C. H. van Aswegen   +2 more
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Inhibitors of the Proteolytic Activity of Urokinase Type Plasminogen Activator

Current Pharmaceutical Design, 2003
Urokinase type plasminogen activator (uPA) activates plasminogen to plasmin and is often associated with diseases where tissue remodeling is essential (e.g. cancer, macular degeneration, atherosclerosis). We discuss some of the mechanisms of uPA action in diseases, and evidence that some of the early uPA inhibitors can modulate the progression of these
Vincent L. Giranda, Todd W. Rockway
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Urokinase-type plasminogen activator

The International Journal of Biochemistry & Cell Biology, 2007
Urokinase-type plasminogen activator (uPA) is a serine protease involved in tissue remodeling and cell migration. At the gene level, the interplay between a complex enhancer, required for induced and basal transcription, and the minimal promoter finely tunes uPA expression.
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Mutations affecting the activity of urokinase-type plasminogen activator

"Protein Engineering, Design and Selection", 1991
Mutagenesis throughout the single-chain urokinase-type plasminogen activator (scu-PA) cDNA molecule, followed by expression of the mutant genes and secretion of the resulting mutant proteins from yeast, has been used to determine the amino acid residues important for activity of scu-PA molecules.
Dennis R. Dumais, Adienne P. Smyth, Jonathan Greer, Lance S. Davidow, Donald T. Moir   +4 more
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Ras Regulation of urokinase-type plasminogen activator

2001
Publisher Summary This chapter describes the Ras regulation of urokinase-type plasminogen activator. Degradation of the extracellular matrix (ECM) is essential in many physiological and pathological processes, including involution of the prostate, cytotrophoblast implantation; wound healing, and tumor cell invasion, all of which require extensive ...
Claudia Jäger, Ernst Lengyel, Manfred Schmitt, Markus M. Heiss, Heike Allgayer, Sabine Ried   +5 more
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Association of Urokinase-type Plasminogen Activator with Asthma and Atopy

American Journal of Respiratory and Critical Care Medicine, 2007
Urokinase plasminogen activator (uPA) interacts with its receptor on inflammatory and migrating cells to regulate extracellular matrix degradation, cell adhesion, and inflammatory cell activation. It is necessary for the development of an appropriate immune response and is involved in tissue remodeling.
Sébastien Claveau, Thomas J. Hudson, Catherine Laprise, Philippe Bégin, Alexandre Montpetit, Allan B. Becker, Sabine Kacel, Anita L. Kozyrskyj, Charleen Salesse, Denise Daley, Mathieu Lemire, Moira Chan-Yeung, Karine Tremblay   +12 more
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A CELLULAR RECEPTOR FOR UROKINASE-TYPE PLASMINOGEN ACTIVATOR [PDF]

Thrombosis and Haemostasis, 1987
Recent cell biological and biochemical studies on the urokinase-type plasminogen activator (u-PA) have revealed an unsuspected property of this protein: it binds with high affinity and specificity to the plasma membrane of a number of cell types. Hence, while the interaction of tissue-type plasminogen activator (t-PA) with fibrin suggests a preferred ...
Annelise Isabelle Wohlwend, D Baccino, A Estreicher, J-D Vassalli, Dominique Belin, J Hurate   +5 more
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