Results 261 to 270 of about 75,327 (314)
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Expression of urokinase‐type plasminogen activator, urokinase‐type plasminogen activator receptor, and plasminogen activator inhibitor‐1 and ‐2 in hepatocellular carcinoma

Pathology International, 2000
It has become more and more clear in recent decades that the plasminogen activation system, which includes urokinase‐type plasminogen activator (uPA), urokinase‐type plasminogen activator receptor (uPAR), plasminogen activator inhibitor (PAI)‐1 and PAI‐2, plays a very important role in the aggressiveness of cancer. Using immunohistochemistry and enzyme‐
Weiping Wang   +5 more
openaire   +3 more sources

Modulation of lipoxidase activity by urokinase-type plasminogen activator

Prostaglandins, Leukotrienes and Essential Fatty Acids, 1994
Malignant cells show increased urokinase (UK) activity and decreased peroxidation of essential fatty acids (EFA). In order to explore this phenomenon the effect of UK on the lipoxidase activity was spectrophotometrically investigated. Decreased lipoxidase activity was obtained with increased UK concentrations (r = -1.000, p < 0.0001).
P.J. Du Toit   +2 more
openaire   +3 more sources

Aberrant glomerular filtration of urokinase-type plasminogen activator in nephrotic syndrome leads to amiloride-sensitive plasminogen activation in urine.

AJP - Renal Physiology, 2015
In nephrotic syndrome, aberrant glomerular filtration of plasminogen and conversion to active plasmin in preurine are thought to activate proteolytically epithelial sodium channel (ENaC) and contribute to sodium retention and edema.
Mette Stæhr   +7 more
semanticscholar   +1 more source

Inhibitors of the Proteolytic Activity of Urokinase Type Plasminogen Activator

Current Pharmaceutical Design, 2003
Urokinase type plasminogen activator (uPA) activates plasminogen to plasmin and is often associated with diseases where tissue remodeling is essential (e.g. cancer, macular degeneration, atherosclerosis). We discuss some of the mechanisms of uPA action in diseases, and evidence that some of the early uPA inhibitors can modulate the progression of these
Vincent L. Giranda, Todd W. Rockway
openaire   +3 more sources

Urokinase-type plasminogen activator

The International Journal of Biochemistry & Cell Biology, 2007
Urokinase-type plasminogen activator (uPA) is a serine protease involved in tissue remodeling and cell migration. At the gene level, the interplay between a complex enhancer, required for induced and basal transcription, and the minimal promoter finely tunes uPA expression.
openaire   +2 more sources

Mutations affecting the activity of urokinase-type plasminogen activator

"Protein Engineering, Design and Selection", 1991
Mutagenesis throughout the single-chain urokinase-type plasminogen activator (scu-PA) cDNA molecule, followed by expression of the mutant genes and secretion of the resulting mutant proteins from yeast, has been used to determine the amino acid residues important for activity of scu-PA molecules.
Dennis R. Dumais   +4 more
openaire   +3 more sources

Ras Regulation of urokinase-type plasminogen activator

2001
Publisher Summary This chapter describes the Ras regulation of urokinase-type plasminogen activator. Degradation of the extracellular matrix (ECM) is essential in many physiological and pathological processes, including involution of the prostate, cytotrophoblast implantation; wound healing, and tumor cell invasion, all of which require extensive ...
Claudia Jäger   +5 more
openaire   +3 more sources

A CELLULAR RECEPTOR FOR UROKINASE-TYPE PLASMINOGEN ACTIVATOR [PDF]

open access: possibleThrombosis and Haemostasis, 1987
Recent cell biological and biochemical studies on the urokinase-type plasminogen activator (u-PA) have revealed an unsuspected property of this protein: it binds with high affinity and specificity to the plasma membrane of a number of cell types. Hence, while the interaction of tissue-type plasminogen activator (t-PA) with fibrin suggests a preferred ...
Annelise Isabelle Wohlwend   +5 more
openaire   +1 more source

Association of Urokinase-type Plasminogen Activator with Asthma and Atopy

American Journal of Respiratory and Critical Care Medicine, 2007
Urokinase plasminogen activator (uPA) interacts with its receptor on inflammatory and migrating cells to regulate extracellular matrix degradation, cell adhesion, and inflammatory cell activation. It is necessary for the development of an appropriate immune response and is involved in tissue remodeling.
Sébastien Claveau   +12 more
openaire   +5 more sources

Hyperglycemia is associated with lower levels of urokinase-type plasminogen activator and urokinase-type plasminogen activator receptor in wound fluid

Journal of Diabetes and its Complications, 2014
Wounds in patients with hyperglycemia show impaired healing. Plasminogen activation is crucial in several overlapping phases of wound healing process. In this study, we aimed i) to compare acute wound fluid in patients with hyperglycemia and normoglycemia, ii) to focus on the elements of plasminogen activation in the wound fluid, and iii) to determine ...
Terzi, Cem   +6 more
openaire   +4 more sources

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