Results 271 to 280 of about 75,327 (314)
Some of the next articles are maybe not open access.
Blood, 2000
Human immunodeficiency virus-1 (HIV-1) infection has been shown to result in up-regulation of the urokinase-type plasminogen activator receptor (uPAR/CD87) on leukocytes in vitro and in vivo. The objective of this study was to investigate whether this up-
N. Sidenius+6 more
semanticscholar +1 more source
Human immunodeficiency virus-1 (HIV-1) infection has been shown to result in up-regulation of the urokinase-type plasminogen activator receptor (uPAR/CD87) on leukocytes in vitro and in vivo. The objective of this study was to investigate whether this up-
N. Sidenius+6 more
semanticscholar +1 more source
Interconversion of Active and Inactive Conformations of Urokinase-Type Plasminogen Activator
Biochemistry, 2012The catalytic activity of serine proteases depends on a salt-bridge between the amino group of residue 16 and the side chain of Asp194. The salt-bridge stabilizes the oxyanion hole and the S1 specificity pocket of the protease. Some serine proteases exist in only partially active forms, in which the amino group of residue 16 is exposed to the solvent ...
Masood Hosseini+9 more
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Current pharmaceutical design, 2003
Degradation of the extracellular matrix plays an important role in a number of normal and pathological conditions involving active tissue remodeling such as postlactational mammary gland involution, wound healing and tumor invasion and metastasis.
M. Ploug
semanticscholar +1 more source
Degradation of the extracellular matrix plays an important role in a number of normal and pathological conditions involving active tissue remodeling such as postlactational mammary gland involution, wound healing and tumor invasion and metastasis.
M. Ploug
semanticscholar +1 more source
European Journal of Biochemistry, 1985
Controlled extracellular proteolysis is catalyzed in part by the secretion of plasminogen activators. As a step in the study of the expression of these enzymes in mouse tissues, we have isolated five cDNAs encoding the mouse urokinase-type plasminogen ...
D. Belin+7 more
semanticscholar +1 more source
Controlled extracellular proteolysis is catalyzed in part by the secretion of plasminogen activators. As a step in the study of the expression of these enzymes in mouse tissues, we have isolated five cDNAs encoding the mouse urokinase-type plasminogen ...
D. Belin+7 more
semanticscholar +1 more source
Inhibitors of the Protease Domain of Urokinase-Type Plasminogen Activator
Current Pharmaceutical Design, 2002Human urokinase-type plasminogen activator (uPA or uPA) has been implicated in the regulation and control of basement membrane and interstitial protein degradation. Since Urokinase plays a role in tissue remodeling, it may be responsible, in part, for the disease progression of cancer.
Vicki L. Nienaber+2 more
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Identification of a novel inhibitor of urokinase-type plasminogen activator
Molecular Cancer Therapeutics, 2007AbstractUrokinase-type plasminogen activator (uPA), a highly restricted serine protease, plays an important role in the regulation of diverse physiologic and pathologic processes. Strong clinical and experimental evidence has shown that elevated uPA expression is associated with cancer progression, metastasis, and shortened survival in patients.
Ming Zhu+8 more
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Modulators of the urokinase-type plasminogen activation system for cancer
Expert Opinion on Investigational Drugs, 2010The serine protease urokinase-type plasminogen activator (uPA) and its receptor uPAR as well as two specific inhibitors, the plasminogen activator inhibitor type-1 (PAI-1) and type-2 (PAI-2), are involved in the control of extracellular matrix turnover and tumor growth.
Alexander Marx+3 more
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Bovine embryos produce a urokinase‐type plasminogen activator
Molecular Reproduction and Development, 1992AbstractThe type of plasminogen activator (PA) secreted by bovine embryos was identified. Day 12–14 embryos were collected from estrus‐synchronized, superovulated, and naturally mated crossbred beef cows. Embryos were left intact (E) or microdissected into component embryonic discs (ED) and trophoblastic vesicles (TV).
A. R. Menino, Debra A. Berg
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Journal of Clinical Oncology, 2002
PURPOSE A strong prognostic impact of urokinase-type plasminogen activator (uPA) and its inhibitor and plasminogen activator inhibitor type 1 (PAI-1) as individual factors is well established in breast cancer.
N. Harbeck, R. Kates, M. Schmitt
semanticscholar +1 more source
PURPOSE A strong prognostic impact of urokinase-type plasminogen activator (uPA) and its inhibitor and plasminogen activator inhibitor type 1 (PAI-1) as individual factors is well established in breast cancer.
N. Harbeck, R. Kates, M. Schmitt
semanticscholar +1 more source
Urokinase-type plasminogen activator in human eccrine sweat
British Journal of Dermatology, 1993The presence of urokinase-type plasminogen activator (uPA) in human eccrine sweat has not been reported previously. Clean sweat was obtained from the upper trunk and arms of subjects which had been painted with white petrolatum to minimize epidermal contamination. Sweat was concentrated x 50 by ultrafiltration, and its PA activity determined by the two-
Kenzo Sato, T. Hibino, T. Takemura
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