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New developments in the urokinase-type plasminogen activator system
Expert Opinion on Therapeutic Targets, 2001The urokinase-type plasminogen activator (uPA) system plays a central role in control of cell surface proteolysis and extracellular matrix degradation. Components of this system are upregulated in a wide variety of human cancers and high levels of these proteins predict more rapid relapse and shorter survival.
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Urokinase-Type Plasminogen Activator and PAI-1
2006Urokinase plasminogen activator (uPA) is a serine protease causally involved in tumor progression. In vivo, uPA can be inhibited by the serpin inhibitor plasminogen activator inhibitor-1 (PAI-1). However, PAI-1 is a multifunctional protein that can also play a role in cell migration, cell adhesion, angiogenesis, and apoptosis.
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Functions of the plasminogen receptor Plg‐RKT
Journal of Thrombosis and Haemostasis, 2020Juliana P Vago +2 more
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Plasminogen Activator Inhibitor Type‐1 as a Regulator of Fibrosis
Journal of Cellular Biochemistry, 2018Maryam Boshtam, Rui Dinis, Hamed Mirzaei
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