Results 201 to 210 of about 27,307 (240)

Urokinase/Urokinase Receptor-Mediated Signaling in Cancer

2007
Experimental oncogenic transformation or in spontaneous human cancers, mitogenesis and expression of fibrinolytic components such as urokinase (uPA), its receptor (uPAR), and its major inhibitor plasminogen activator inhibtor-1 (PAI-1) or -2 (PAI-2) are activated by common signaling mechanisms.
Sreerama Shetty, Steven Idell
openaire   +1 more source

Urokinase and urokinase receptor expression in somatic cell hybrids

Fibrinolysis, 1994
To study the mechanisms that control cell-bound urokinase (u-PA) activity we characterised the expression of u-PA and its cellular receptor (u-PAR) in somatic cell hybrids between mouse L fibroblasts that do not produce u-PA and human HT1080 fibrosarcoma cells that express high levels of u-PA and u-PAR. Although the hybrids possessed a number of copies
Mazzieri R., Høyer Hansen G., Rønne E., Løber D., Vagnarelli P., De Carli L., Danø K., Mignatti P., RAIMONDI, ELENA MARIA   +8 more
openaire   +4 more sources

Urokinase and its Receptor: Markers of Malignancy?

1994
For many years it has been known that abnormal coagulation and fibrinolytic activity existed in the environs of malignant tumours. Whether these activities affected the invasiveness and metastatic activity of tumours has been in question for some time.
P J, Gaffney, D A, Cooke, K G, Burnand
openaire   +2 more sources

Regulation of Integrin Function by the Urokinase Receptor

Science, 1996
Integrin function is central to inflammation, immunity, and tumor progression. The urokinase-type plasminogen activator receptor (uPAR) and integrins formed stable complexes that both inhibited native integrin adhesive function and promoted adhesion to vitronectin via a ligand binding site on uPAR.
Y, Wei, M, Lukashev, D I, Simon, S C, Bodary, S, Rosenberg, M V, Doyle, H A, Chapman   +6 more
openaire   +2 more sources

The Urokinase Receptor in the Central Nervous System

CNS & Neurological Disorders - Drug Targets, 2011
The urokinase receptor (uPAR) is a multifunctional glycosylphosphatidylinositol-anchored protein that regulates important processes such as gene expression, cell proliferation, adhesion, migration, invasion, and metastasis. uPAR is an essential component of the plasminogen activation cascade, a protease receptor that binds the urokinase-type ...
Marco, Archinti, Mishan, Britto, Gabriele, Eden, Federico, Furlan, Ronan, Murphy, Bernard, Degryse   +5 more
openaire   +2 more sources

Urokinase-catalysed cleavage of the urokinase receptor requires an intact glycolipid anchor

Biochemical Journal, 2001
Urokinase (uPA) has the striking ability to cleave its receptor, uPAR, thereby inactivating the binding potential of this molecule. Here we demonstrate that the glycosylphosphatidylinositol (GPI) anchor of uPAR, which is attached to the third domain, is an important determinant in governing this reaction, even though the actual cleavage occurs between ...
Høyer-Hansen, G, Pessara,, Ulrich, Holm, A, Pass, J, Weidle, U., Danø, K, Behrendt, N   +6 more
openaire   +2 more sources

Urokinase plasminogen activator and urokinase plasminogen activator receptor in breast cancer

International Journal of Cancer, 1995
AbstractUrokinase plasminogen activator (uPA) is a serine protease involved in cancer invasion and metastasis. uPA mediates its action while attached to a membrane‐bound receptor (uPAR). In this investigation we show that uPAR levels correlate with uPA levels in human breast cancers.
C, Duggan, T, Maguire, E, McDermott, N, O'Higgins, J J, Fennelly, M J, Duffy   +5 more
openaire   +2 more sources

Novel Control of Urokinase Receptor Expression

Physiology, 1998
In this section we feature some of the latest and most striking new findings in physiology, interpreting the term “physiology” in its broadest sense. In each instance, an effort will be made to place the new findings in perspective.
openaire   +2 more sources

Inhibition of urokinase activity and prevention of urokinase receptor binding by monoclonal antibodies

Journal of Immunological Methods, 1990
Two murine monoclonal antibodies produced against human urokinase-type plasminogen activator were characterized with respect to their antigen-binding specificity and their effects on urokinase activity and urokinase receptor binding. One of the antibodies binds to the protease domain of urokinase (Kass = 2.1 X 10(7) M-1).
U, Zacharias, W, Handschack, F, Schneider, K, Löster, C, Kleitke, F, Noll, H, Will   +6 more
openaire   +2 more sources

Structure and function of the urokinase receptor

Blood Coagulation & Fibrinolysis, 1993
The urokinase plasminogen activator receptor (u-PAR), present on the surface of a number of cell types, is a key component in the plasminogen activation system where it serves to localize and accelerate the activation cascade. In the present review, structural and functional aspects of u-PAR are discussed with special emphasis on newer findings.
openaire   +3 more sources