Results 51 to 60 of about 17,246 (259)

Ragomics‐Meta: An open‐source, scalable, reproducible, and extensible multi‐omics analysis workflow

open access: yesiMetaOmics, EarlyView.
Ragomics‐Meta is an open‐source, scalable, and reproducible multi‐omics workflow for metabolism‐centered analysis (https://www.raganetwork.com/). It integrates scRNA/snRNA‐seq, spatial transcriptomics, scATAC‐seq, and metabolomics modules to support quality control, dimensionality reduction, clustering, differential expression and accessibility ...
Zeping Gui   +11 more
wiley   +1 more source

Antimicrobial resistance in pediatric patients with urinary tract infection

open access: yesRevista Electrónica Dr. Zoilo E. Marinello Vidaurreta, 2018
Background: antimicrobial resistance in pediatric patients with urinary tract infection is a growing problem, with an important medical impact. Nowadays, resistance of E.
Zunilda Leticia Bello-Fernández   +4 more
doaj  

The dynamics of morbidity and provision of urological resources in the Republic of Kazakhstan

open access: yesClinical Epidemiology and Global Health
Background: This study aims to analyze the prevalence of diseases of the genitourinary system in the Republic of Kazakhstan from 2015 to 2022. Methods: We used the information from the primary registration database of the incidence of diseases of the ...
Turar Kurmanbekov   +3 more
doaj   +1 more source

Case Presentation: Lung Consolidation as Sequelae of BCG Sepsis After Combined Intravesical and Intraurethral BCG

open access: yesUrology Case Reports, 2017
BCG sepsis is rarely seen with modern intravesical therapy and therefore its presentation may not be apparent to recently trained urologists. We describe BCG sepsis occurring in a patient treated with combined intravesical and intraurethral BCG which ...
Jeffrey R. Strich   +7 more
doaj   +1 more source

Past, Present, and Future of Telerobotic Surgery in Urology: From Technological Breakthroughs to Global Adoption

open access: yesiNew Medicine, EarlyView.
The Development and Future of Remote Robots in Urology. ABSTRACT Ever since the “Lindbergh Operation” in 2001, the field of remote robotic surgery has transformed from theoretical study toward practical clinical integration on a global scale. Considering the millimeter‐level precision that is required in the field of urological oncology, remote ...
Cheng Yang   +6 more
wiley   +1 more source

FAM107A loss facilitates TTK‐OPTN‐mediated mitophagy to drive docetaxel resistance in castration‐resistant prostate cancer

open access: yesInterdisciplinary Medicine, EarlyView.
In the progression of docetaxel resistance, downregulation of FAM107A releases its transcriptional repression of TTK, leading to TTK upregulation. TTK enhances the interaction and phosphorylation of OPTN. This activates mitophagy in tumor cells, facilitates clearance of damaged mitochondria, reduces intracellular reactive oxygen species accumulation ...
Yishan Zhang   +11 more
wiley   +1 more source

Comprehensive dietary patterns explain acquired cystic kidney disease risk through genetic and metabolomic mechanisms

open access: yesFrontiers in Nutrition
BackgroundAcquired renal cysts (ARC) are associated with kidney function decline, necessitating novel dietary pattern (DP) analyses in large cohorts.MethodsThis UK Biobank prospective cohort study (2006–2010) included participants with ≥2 dietary records,
Chenhao Xu   +14 more
doaj   +1 more source

An Hsp90 co-chaperone protein in yeast is functionally replaced by site-specific posttranslational modification in humans

open access: yesNature Communications, 2017
The eukaryotic heat shock protein 90 (Hsp90) undergoes an ATP-dependent conformational cycle that is influenced by posttranslational modifications and co-chaperones.
Abbey D. Zuehlke   +14 more
doaj   +1 more source

Targeting the intratumoral microbiota to overcome cancer immunotherapy resistance

open access: yesInterdisciplinary Medicine, EarlyView.
This review delineates the mechanisms of intratumoral microbiota in cancer immunotherapy resistance, and offers strategies for microbiota‐targeted precision immunotherapy. Abstract Cancer remains a significant global health threat. The tumor microenvironment (TME) is a sophisticated ecological niche that exerts a pivotal effect on treatment outcomes ...
Bufu Tang   +14 more
wiley   +1 more source

Impact of perioperative blood transfusions on clinical outcomes in patients undergoing surgery for major urologic malignancies

open access: yesTherapeutic Advances in Urology, 2019
The association between allogeneic perioperative blood transfusion (PBT) and decreased survival among patients undergoing various oncological surgeries has been established in various malignant diseases, including colorectal, thoracic and hepatocellular ...
Yasmin Abu-Ghanem, Jacob Ramon
doaj   +1 more source

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