Results 231 to 240 of about 106,373 (291)

FAM107A loss facilitates TTK‐OPTN‐mediated mitophagy to drive docetaxel resistance in castration‐resistant prostate cancer

Interdisciplinary Medicine, Volume 4, Issue 5, September 2026.
In the progression of docetaxel resistance, downregulation of FAM107A releases its transcriptional repression of TTK, leading to TTK upregulation. TTK enhances the interaction and phosphorylation of OPTN. This activates mitophagy in tumor cells, facilitates clearance of damaged mitochondria, reduces intracellular reactive oxygen species accumulation ...
Yishan Zhang, Fan Zou, Mingdong Wang, Chenyue Wu, Yingwei Xie, Yongjun Quan, Wei Yan, Yupeng Zheng, Lianhua Li, Yuexin Liu, Jian Yu, Hao Ping   +11 more
wiley   +1 more source

Neoadjuvant lenvatinib and pembrolizumab for metastatic clear cell renal cell carcinoma: A potential opportunity for complete pathologic and radiographic response. [PDF]

Urol Case Rep
Walker EK, Leong JY, Aron M, Aron M.
europepmc   +1 more source

Targeting the intratumoral microbiota to overcome cancer immunotherapy resistance

Interdisciplinary Medicine, Volume 4, Issue 5, September 2026.
This review delineates the mechanisms of intratumoral microbiota in cancer immunotherapy resistance, and offers strategies for microbiota‐targeted precision immunotherapy. Abstract Cancer remains a significant global health threat. The tumor microenvironment (TME) is a sophisticated ecological niche that exerts a pivotal effect on treatment outcomes ...
Bufu Tang, Tong Jiang, Yaling Lin, Wei Zhang, Hongjie Fan, Minjie Yang, Bingzhe Li, Yaozu Liu, Changyu Li, Xuran Jin, Wen Zhang, Zhiping Yan, Qianqian Zhao, Xuefeng Kan, Xudong Qu   +14 more
wiley   +1 more source

A urologic manifestation of carney complex: Bilateral Sertoli tumors and scrotal myxoma in an adolescent male. [PDF]

Urol Case Rep
Walter E, Wolfe A, Yu Z, Rensing A.
europepmc   +1 more source

CircFut8 Suppresses Bladder Cancer by Modulating SRSF9‐Dependent Pre‐mRNA Splicing

The Journal of Gene Medicine, Volume 28, Issue 9, September 2026.
This schematic illustrates the mechanism by which circFut8 suppresses bladder cancer progression. Under high circFut8 levels, circFut8 competitively binds the splicing factor SRSF9, reducing SRSF9's association with FUT8 pre‐mRNA. This promotes exon 3 skipping, leading to increased production of the FUT8‐4 splice variant, which correlates with reduced ...
Weifeng Yang, Lv Yao, Lijun Wan, Changshui Zhuang   +3 more
wiley   +1 more source

Advancing Genitourinary Cancer Surgery: The Role of Artificial Intelligence and Robotics. [PDF]

J Clin Med
Katsimperis S, Kostakopoulos N, Bellos T, Spinos T, Peteinaris A, Tzelves L, Kostakopoulos A, Skolarikos A.   +7 more
europepmc   +1 more source

A retrospective observational analysis of the global burden of smoking-attributable prostate, bladder, and kidney cancers among adults aged 40 years and older: Based on the global burden of disease study 2021 with projections to 2045. [PDF]

Sci Prog
Chen N, Cai J, Feng J, He Y, Xu D.
europepmc   +1 more source

Life after radical cystectomy: A mixed-methods targeted review of patient-reported quality of life following bladder removal. [PDF]

BJUI Compass
Griebsch I, Juul K, Bottomley A, Sherafat-Kazemzadeh R, Pemment J, Brooks T, Adiutori R, Bothorel S.   +7 more
europepmc   +1 more source

Perioperative Optimization Strategies in Major Genitourinary Cancer Surgery. [PDF]

Cancers (Basel)
Yellu A, Weitzner AS, Cronin C, Kim JK, Lokeshwar SD.   +4 more
europepmc   +1 more source

Oral microbiota and urinary system diseases: from mechanistic insights to clinical implications-a comprehensive review. [PDF]

Front Dent Med
Chen H, Chen Y, Liu Y, Chen C.
europepmc   +1 more source