Results 51 to 60 of about 416,564 (362)

Adverse prognosis gene expression patterns in metastatic castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
We aggregated a cohort of 1012 mCRPC tissue samples from 769 patients and investigated the association of gene expression‐based pathways with clinical outcomes. Loss of AR signaling, high proliferation, and a glycolytic phenotype were independently prognostic for poor outcomes, and an adverse transcriptional feature score incorporating these pathways ...
Marina N. Sharifi, Eric Feng, Nicholas R. Rydzewski, Amy K. Taylor, Jamie M. Sperger, Yue Shi, Kyle T. Helzer, Matthew L. Bootsma, Viridiana Carreno, Alex H. Chang, Luke A. Nunamaker, Grace C. Blitzer, Tianfu Andy Shang, Aishwarya Subramanian, Anders Bjartell, Andreas Josefsson, Pernilla Wikström, Emily Feng, Manish Kohli, Rendong Yang, Scott M. Dehm, Eric J. Small, Rahul Aggarwal, David A. Quigley, Joshua M. Lang, Shuang G. Zhao, Martin Sjöström   +26 more
wiley   +1 more source

Prevalence of chronic kidney disease and associated factors among patients with underlying chronic disease at Dessie Referral Hospital, East Amhara Region, Ethiopia

Frontiers in Epidemiology, 2023
BackgroundChronic kidney disease is defined as a reduction in glomerular filtration rate below 60 ml/min per 1.73 m2 and presence of albuminuria over a period of time. Globally, 10%–15% of populations are affected by chronic kidney disease.
Ahmed Ali, Kebadnew Mulatu, Sefineh Fenta Feleke, Gizachew Tadesse Wassie   +3 more
doaj   +1 more source

Development of a Novel Robot for Transperineal Needle Based Interventions: Focal Therapy, Brachytherapy and Prostate Biopsies [PDF]

Journal of Urology 188 (2012) 1369-1374, 2012
Purpose: We report what is to our knowledge the initial experience with a new 3-dimensional ultrasound robotic system for prostate brachytherapy assistance, focal therapy and prostate biopsies. Its ability to track prostate motion intraoperatively allows it to manage motions and guide needles to predefined targets.
arxiv   +1 more source

Aberrant expression of nuclear prothymosin α contributes to epithelial‐mesenchymal transition in lung cancer

Molecular Oncology, EarlyView.
Nuclear prothymosin α inhibits epithelial‐mesenchymal transition (EMT) in lung cancer by increasing Smad7 acetylation and competing with Smad2 for binding to SNAI1, TWIST1, and ZEB1 promoters. In early‐stage cancer, ProT suppresses TGF‐β‐induced EMT, while its loss in the nucleus in late‐stage cancer leads to enhanced EMT and poor prognosis.
Liyun Chen, Chung‐Teng Wang, Jia‐Ming Chang, Ai‐Li Shiau, Gia‐Shing Shieh, Yau‐Lin Tseng, Yi‐Ting Yen, Tang‐Hsiu Huang, Li‐Hsin Cheng, Yu‐Chih Wu, Chao‐Liang Wu, Bing‐Hua Su, Pensee Wu   +12 more
wiley   +1 more source

Online Interest in Urology Residency: A Comprehensive Analysis of Current Internet Temporal and Geographic Patterns

International Medical Education
Urology is one of the most competitive specialties in medicine, creating a challenge for prospective students looking to secure a residency position. Our study aims to assess online interest in urology residency by querying online interaction with search
Arthur Drouaud, Ryan Antar, Vincent Xu, Paul Nagao, Sean Tafuri, Michael Whalen   +5 more
doaj   +1 more source

The influence of online posting dates on the bibliometric indicators of scientific articles [PDF]

ECHEVERRIA, Mercedes; STUART, David; CORDON-GARCIA, Jose Antonio (2017). The influence of online posting dates on the bibliometric indicators of scientific articles. Revista espanola de Documentacion Cientifica, v. 40, n. 3, p. e183, 2018
This article analyses the difference in timing between the online availability of articles and their corresponding print publication and how it affects two bibliometric indicators: Journal Impact Factor (JIF) and Immediacy Index. This research examined 18,526 articles, the complete collection of articles and reviews published by a set of 61 journals on
arxiv   +1 more source

High-dose Chemotherapy with Peripheral Blood Stem Cell Transplantation for Patients with Poor PrognosisAdvanced Germ Cell Tumor [PDF]

, 2011
SUMMARYAbout one half of all advanced germ cell tumor( GCT) patients with poor prognosis defined by the InternationalGerm Cell Cancer Collaborative Group (IGCCCG) die of cancer. We evaluated salvage high-dosechemotherapy (HDCT) with peripheral blood stem
Akinori Masuda, Department of Urology, Dokkyo Medical University, Department of Urology, Dokkyo Medical University, Department of Urology, Dokkyo Medical University, Department of Urology, Dokkyo Medical University, Department of Urology, Dokkyo Medical University, Department of Urology, Dokkyo Medical University, Department of Urology, Dokkyo Medical University, Department of Urology, Dokkyo Medical University, Department of Urology, Dokkyo Medical University, Department of Urology, Dokkyo Medical University, Department of Urology, Dokkyo Medical University Nikko Medical Center, Hideyuki Abe, Ken-ichiro Yoshida, Kimihiro Nakanishi, Mikihiko Honda, Nobutaka Furuya, Takao Kamai, Tomonori Yamanishi, Tomoya Mizuno, Tsunehito Kambara, Yoshitatsu Fukabori   +21 more
core   +1 more source

Metabolic Reprogramming of Cancer‐Associated Fibroblasts: Transforming Tumor Accomplices into Immunotherapeutic Allies

Advanced Functional Materials, Volume 35, Issue 13, March 25, 2025.
This study presents an FAP‐targeted LNP system designed to selectively target CAFs in CRPC. By inhibiting hexokinase 2 (HK2) and mitochondrial cytochrome c oxidase I (MTCO1), CAFs are reprogrammed from tumor‐promoting cells to immune‐supportive allies. This dual inhibition enhances T cell infiltration, suppresses angiogenesis, and improves the efficacy
Feng Qi, Dong Fu, Hongzhou Cai, Yuxiao Zheng, Ning Wang, Zicheng Xu   +5 more
wiley   +1 more source

Personal, professional and financial satisfaction among American women urologists

International Brazilian Journal of Urology, 2011
PURPOSE: Although nearly half of American medical school classes are comprised of women, less than 5% of female medical students enter the surgical subspecialties compared to nearly 20% of male students.
Ciara S. Marley, Lori B. Lerner, Georgia Panagopoulos, Elizabeth Kavaler   +3 more
doaj   +1 more source

Free ureteral replacement in rats: regeneration of ureteral wall components in the acellular matrix graft. [PDF]

, 1997
ObjectivesTo evaluate ureteral replacement by a free homologous graft of acellular matrix in a rat model.MethodsIn 30 male Sprague-Dawley rats, a 0.3 to 0.8-cm midsegment of the left ureter was resected and replaced with an acellular matrix graft of ...
Dahiya, R, Dahms, SE, Lue, TF, Nunes, L, Piechota, HJ, Tanagho, EA   +5 more
core   +1 more source