Results 61 to 70 of about 360,869 (356)
Advanced Science, EarlyView.FPD‐GELNs co‐deliver Su and bioactive components. This active‐passive dual‐targeting strategy suppresses the progression of RCC through the following mechanisms: 1) inhibition of the PI3K‐Akt signaling pathway; 2) downregulation of ABCB1/P‐gp to enhance the chemosensitivity of RCC to Su; and 3) reprogramming of macrophages toward M1 polarization and ...
Haoyu Xu +8 more
wiley +1 more source
Venous thromboembolism: A problem in the Indian/Asian population?
Indian Journal of Urology, 2009 Venous thromboembolism (VTE) is a common and potentially life threatening condition. It continues to be under diagnosed and undertreated. Awareness among Indians regarding this potentially life-threatening disease is low.
Sunil Agarwal +3 more
doaj +1 more source
Advanced Science, EarlyView.PBRM1 ranks as the second most commonly mutated gene in ccRCC. This study reveals that PBRM1 loss promotes an immunosuppressive microenvironment by elevating M2 TAMs via the KDM5C–IL‐6 axis. These M2 TAMs, along with CAFs, form a barrier that excludes CD8+ T cells. Targeting IL‐6 synergizes with anti‐PD1 therapy, offering a promising strategy for PBRM1‐
Wenjiao Xia +14 more
wiley +1 more source
Gomal Journal of Medical Sciences, 2022 Background: Urinary stone disease is one of the commonest urological diseases worldwide. The objective of this study was to compare the efficacy of alfuzosin versus control group in upper ureteric stone expulsion in adult population of district Lahore ...
Fawad Humayun +5 more
doaj
Targeting Endothelial KDM5A to Attenuate Aging and Ameliorate Age‐Associated Metabolic Abnormalities
Advanced Science, EarlyView.This study identifies endothelial KDM5A as a key regulator of aging. KDM5A deficiency accelerates aging by enhancing H3K4me3‐mediated FABP4 expression, disrupting fatty acid metabolism, and promoting multi‐organ senescence. KDM5A restoration or FABP4 inhibition reverses these adverse effects and extends lifespan, positioning the KDM5A/FABP4 axis as a ...
Rifeng Gao +21 more
wiley +1 more source
What should urologists know about evidence-based medicine?
Indian Journal of Urology, 2011 Objectives: This article outlines the basic principles of evidence-based medicine (EBM) and provides urologists with some tools to further explore, understand, and work with EBM.
Jan W Mazel, Rudolf W Poolman
doaj +1 more source
Urethral reconstruction and genitoplasty highlighted in International Brazilian Journal of Urology [PDF]
, 2021 Luciano A. Favorito
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Advanced Science, EarlyView.This study demonstrates that dual UCP2/IL‐17 blockade reprograms T‐cell metabolism to overcome PDAC immunosuppression. Genipin‐mediated UCP2 inhibition enhances CD8⁺ T‐cell IFN‐γ via IL‐12R/STAT4/mTOR signaling and mitochondrial OXPHOS. Combined IL‐17 depletion amplifies Tc1/Th1 responses, reduces MDSCs, and prolongs survival in PDAC models ...
Chuan‐Teng Liu +11 more
wiley +1 more source
Advanced Science, EarlyView.This study presents an intravesical delivery strategy of ferroptosis‐ and immunity‐inducing nanozyme‐loaded thermoresponsive hydrogels (FMCC@PNH) for enhanced bladder cancer therapy. Abstract Current intravesical therapies for bladder cancer after resection are limited by poor tissue penetration, off‐target effects, and insufficient efficacy.
Yongnan Jiang +11 more
wiley +1 more source
Lower Urinary Tract Symptoms in Men Living with Human Immunodeficiency Virus: A Case-control Study
Journal of Urological SurgeryObjective: Human immunodeficiency virus (HIV)/acquired immune deficiency syndrome constitutes a global pandemic affecting populations worldwide. There’s a gap in data regarding lower urinary tract symptoms (LUTS) among men living with HIV (MLWH) during ...
Ersin Köseoğlu +5 more
doaj +1 more source