Structure-based discovery of glycomimetic FmlH ligands as inhibitors of bacterial adhesion during urinary tract infection [PDF]
, 2018 Significance The emergence of multidrug-resistant bacteria, including uropathogenic Escherichia coli (UPEC), makes the development of targeted antivirulence therapeutics a critical focus of research.
Chugani, Ryan +8 more
core +2 more sources
Adaptations of Escherichia coli strains to oxidative stress are reflected in properties of their structural proteomes. [PDF]
, 2020 BACKGROUND:The reconstruction of metabolic networks and the three-dimensional coverage of protein structures have reached the genome-scale in the widely studied Escherichia coli K-12 MG1655 strain.
Catoiu, Edward +6 more
core +2 more sources
Phenotypic microarrays suggest Escherichia coli ST131 is not a metabolically distinct lineage of extra-intestinal pathogenic E. coli [PDF]
, 2014 Extraintestinal pathogenic E. coli (ExPEC) are the major aetiological agent of urinary tract infections (UTIs) in humans. The emergence of the CTX-M producing clone E. coli ST131 represents a major challenge to public health worldwide.
A Coelho +46 more
core +6 more sources
Virulence Factors of Uropathogenic E. coli
, 2019 من أجل عدوى ناجحة وخلق بيئة مرضية داخل المضيف، تحتاج سلالات الإشريكية القولونية المسببة للأمراض البولية (UPEC) إلى بعض الميزات الخاصة التي يتم تحقيقها من خلال التعبير عن جينات معينة، تسمى عوامل الفوعة. اثنان من أهم عوامل الفوعة السطحية لـ UPEC هما النوع 1 fimbriae و P fimbriae التي تعتبر حاسمة لعملية الاستعمار داخل المسالك البولية.
Md. Sorwer Alam Parvez, Dolilur Rahman
openaire +2 more sources
The emergence and fate of horizontally acquired genes in Escherichia coli [PDF]
, 2008 Bacterial species, and even strains within species, can vary greatly in their gene contents and metabolic capabilities. We examine the evolution of this diversity by assessing the distribution and ancestry of each gene in 13 sequenced isolates of ...
Passel, M.W.J., van +2 more
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Primer relevamiento de marcadores de resistencia a antibióticos en Enterobacteriaceae en Cochabamba, Bolivia [PDF]
, 2017 Se llevó a cabo un relevamiento molecular de la resistencia a antibióticos de importancia clínica en aislamientos recuperados en Cochabamba, Bolivia. Se estudiaron los genes codificantes de β-lactamasas de espectro extendido y de resistencia a quinolonas
Di Conza, José Alejandro +3 more
core +1 more source
Prevalence and molecular characterization of extended spectrum beta-Lactamases-producing uropathogenic Escherichia coli isolated in Zakho, Iraq [PDF]
Journal of Microbiology and Infectious Diseases, 2017 Objectives: Uropathogenic Escherichia coli are the most important group of microorganisms responsible for urinary tract infection. A high percentage of uropathogenic E. coli over the world are detected to be ESBLs producers, which is now a problem that
Reem F Polse, Samira Y Yousif, Mahde Saleh Assafi
doaj +1 more source
Antibiotics, 2021 The resistance of uropathogens to various antibiotics is increasing, but nitroxoline remains active in vitro against some relevant multidrug resistant uropathogenic bacteria. E.
Ulrich Dobrindt +5 more
doaj +1 more source
ARO-The Scientific Journal of Koya University, 2022 Emergence of drug resistance in Escherichia coli due to various mechanisms makes the treatment choices very limited. The objective of this research was to investigate extended-spectrum beta-lactamases (ESBLs) and AmpC lactamases in E.
Aryan R. Ganjo
doaj +1 more source
Donor-strand exchange in chaperone-assisted pilus assembly revealed in atomic detail by molecular dynamics [PDF]
, 2008 Adhesive multi-subunit fibres are assembled on the surface of many pathogenic bacteria via the chaperone-usher pathway. In the periplasm, a chaperone donates a β-strand to a pilus subunit to complement its incomplete immunoglobulin-like fold.
Ashcroft, A.E. +5 more
core +1 more source