Results 101 to 110 of about 3,069,601 (247)

Health-related quality of life study of tislelizumab versus single-agent chemotherapy in second-line treatment for advanced urothelial cancer in real-world clinical practice

Zhongguo aizheng zazhi, 2020
Background and purpose: Single-agent chemotherapy shows limited efficacy in second-line treatment for advanced urothelial cancer patients, and significantly reduces the quality of life (QoL) of patients.
BIAN xiaojie, SHEN yijun, ZHU yiping, MA chunguang, GU chengyuan, YE dingwei   +5 more
doaj  

A multilevel perspective on MSH6‐associated Lynch syndrome: Integrating molecular, biological, and clinical insights

International Journal of Cancer, EarlyView.
Abstract Lynch syndrome (LS) is the most common hereditary colorectal cancer syndrome, caused by a germline pathogenic variant in one of the mismatch repair (MMR) genes. Among these, MSH6‐associated LS represents a distinct subtype with unique molecular and clinical characteristics.
Salwa Ben Yahia, Anne‐Sophie van der Werf‐'t Lam, Madalina Cabuta, Maartje Nielsen, Noah C. Helderman   +4 more
wiley   +1 more source

Colorectal Cancer Screening in Hereditary and Familial High‐Risk Populations: Best Practices and Future Directions

International Journal of Cancer, EarlyView.
ABSTRACT Colorectal cancer (CRC) remains a leading cause of cancer‐related morbidity and mortality worldwide yet is largely preventable through effective screening and surveillance. While most CRC cases are sporadic, a substantial proportion occur in individuals at increased risk due to hereditary cancer syndromes or family history who require tailored
Ophir Gilad, Francesc Balaguer, Elizabeth E. Half, Kevin J. Monahan, Elena M. Stoffel, Sonia S. Kupfer   +5 more
wiley   +1 more source

Variant isoforms of CD44 involves acquisition of chemoresistance to cisplatin and has potential as a novel indicator for identifying a cisplatin-resistant population in urothelial cancer

BMC Cancer, 2018
Background Cisplatin is the most commonly used chemotherapeutic agent in the treatment of patients with metastatic and/or recurrent urothelial cancer. However, the effectiveness of these treatments is severely limited due to the development of cisplatin ...
Masayuki Hagiwara, Eiji Kikuchi, Nobuyuki Tanaka, Takeo Kosaka, Shuji Mikami, Hideyuki Saya, Mototsugu Oya   +6 more
doaj   +1 more source

Cancer Trends: Cancers of the testis

, 2012
An average of 132 cases of testicular cancer was diagnosed per year in Ireland between 1994 and 2010 (Table 1). Almost all cases were microscopically verified (98%) and were germ-cell tumours—57% of which were seminomatous and 40% non-seminomatous ...
National Cancer Registry Ireland (NCRI)
core  

Epigenetic Predictors of Smoking: External Validation and Association With Smoking‐Related Cancer Risk

International Journal of Cancer, EarlyView.
ABSTRACT Tobacco smoking has a strong influence on DNA methylation (DNAm), enabling the development of DNAm‐based smoking predictors, yet external evaluations of these have remained limited. We aimed to assess six DNAm‐based smoking predictors in a large sample of middle‐aged and older Australians for (i) their accuracy and reliability, and (ii) their ...
Xiaoyu Fan, Danmeng Lily Li, Allison M. Hodge, Julie K. Bassett, Nina Afshar, Melissa C. Southey, Graham G. Giles, Roger L. Milne, Pierre‐Antoine Dugué   +8 more
wiley   +1 more source

Multi‐omics–driven precision medicine

iMeta, EarlyView.
Multi‐omics‐driven precision medicine (MODPM) provides a multiscale, continuously learnable framework that integrates genomics, epigenomics, transcriptomics, proteomics, metabolomics, microbiome profiles, and clinical data. Powered by artificial intelligence and foundation models, MODPM enables cross‐modal representation learning, contextual modeling ...
Huibo Li, Zhe Zhao, Yifan Zhang, Yao Ma, Gaofei Hu, Min Zeng, Zhanqun Yang, Zixuan Zhao, Xin Zhou, Wei Hu, Yuxuan Sun, Meng Su, Jun Li, Matthew Whiteman, Wei Fu, Chao Zhong, Lemin Zheng, Long Chen, Hairong Lv, Rongsheng Zhao, Yi Zhun Zhu   +20 more
wiley   +1 more source

Long-Term Survival after Adrenalectomy for Asynchronous Metastasis of Bladder Cancer to the Bilateral Adrenal Glands

Case Reports in Urology, 2012
Isolated adrenal metastasis of bladder cancer, particularly the bilateral, is quite rare. Systemic chemotherapy is the treatment of choice for metastatic urothelial carcinoma.
S. Washino, M. Hirai, A. Matsuzaki, Y. Kobayashi   +3 more
doaj   +1 more source

The nuclear membrane in multidrug resistance: microinjection of epirubicin into bladder cancer cell lines

, 2005
Objevtive: to assess whether microinjecting epirubicin into cells showing multidrug resistance (MDR, common to many cancers, including bladder cancer, with resistance to, e.g.
Birch, B.R, Hayes, C.M, Featherstone, J.F, Cooper, A.J, Speers, A.G, Lwaleed, B.A   +5 more
core   +1 more source

Fosciclopirox suppresses growth of high-grade urothelial cancer by targeting notch signaling

, 2020
AACR Annual Meeting -- JUN 22-24, 2020 -- ELECTR NETWORKCiclopirox (CPX) is an FDA-approved topical antifungal agent that has demonstrated preclinical anticancer activity in a number of solid and hematologic malignancies.
Anant, Shrikant, McCulloch, William, Dalton, Michael, Baltezor, Michael J., Brinker, Amanda, Weir, Scott James, Ranjarajan, Parthasarathy, Woolbright, Benjamin L., Wood, Robyn, Jensen, Roy A., Ham, Tammy, Bhattacharyya, Sangita, Ramamoorthy, Prabhu, Tanol, Mehmet, Standing, David, Reed, Gregory A., Dandawate, Prasad   +16 more
core   +1 more source