Results 91 to 100 of about 62,685 (235)

T Cell Microenvironmental Impacts and Therapeutic Opportunities: Application to Human Testicular Germ Cell Tumors

Andrology, EarlyView.
ABSTRACT Testicular germ cell tumors (TGCT) are the leading malignancy in adolescent and young adult males, yet the immunological and cellular mechanisms governing their tumor microenvironment (TME) remain poorly understood. Here, we present a comprehensive review of TGCT pathobiology with a focus on the immune landscape, particularly the role of tumor‐
R Islam, M Figura, J Heyer, S Lieber, M Huber, KL Loveland, HC Schuppe, Daniela Fietz   +7 more
wiley   +1 more source

A Rare Variant of Urothelial Carcinoma: Plasmacytoid Urothelial Carcinoma

Turkiye Klinikleri Journal of Case Reports, 2022
Kazım CEVİZ, Muhammed Emin POLAT, Emre UZUN, Lütfi İhsan BOYACI, Cavit CEYLAN   +4 more
openaire   +1 more source

The Functional Role and Molecular Characterization of the Therapeutic Target CLDN6 in Germ Cell Tumors

Andrology, EarlyView.
ABSTRACT Background The tight junction protein CLDN6 has been identified as a cancer‐associated cell surface marker that is rarely expressed in healthy tissues. In testicular germ cell tumors (GCT), CLDN6 is particularly detectable in seminomas, embryonal carcinomas, and choriocarcinomas.
Jule Zwick, Margaretha A. Skowron, Gereon Poschmann, Patrick Petzsch, Ann Kathrin Bergmann, Kai Stühler, Jochen Hecht, Daniel Nettersheim   +7 more
wiley   +1 more source

Upper tract urothelial carcinoma in crossed fused renal ectopia: Case report and review of the literature

Urology Case Reports
Upper tract urothelial carcinoma in conjunction with congenital renal malformations is exceedingly rare in clinical practice, presenting significant challenges for surgical intervention.
Xiaoxuan Bai, Suzhan Lv, Dan Liu, Yuexin Liu, Hao Ping   +4 more
doaj   +1 more source

Androgen Receptor Expression in Urothelial Bladder Cancer—A Systematic Review and Meta‐Analysis

ANZ Journal of Surgery, EarlyView.
ABSTRACT Background Bladder cancer is a globally prevalent malignancy with a marked male predominance. Over the past decade, the androgen receptor has been investigated as a potential contributor to bladder cancer pathophysiology. Androgen receptor expression is most commonly assessed via immunohistochemistry, but its association with pathological ...
Alex Buckby, Mandana Gholami, Matthew Hong, Michael O'Callaghan   +3 more
wiley   +1 more source

A luminal non‐coding RNA‐based genomic classifier confirms favourable outcomes in patients with clinically organ‐confined bladder cancer treated with radical cystectomy

BJU International, Volume 135, Issue 4, Page 648-656, April 2025.
Objective To further evaluate a genomic classifier (GC) in a cohort of patients undergoing radical cystectomy (RC), as long non‐coding RNA (lncRNA)‐based genomic profiling has suggested utility in identifying a distinct tumour subgroup corresponding to a favourable prognosis in patients with bladder cancer.
Joep J. de Jong, James A. Proudfoot, Siamak Daneshmand, Robert S. Svatek, Vikram Narayan, Ewan A. Gibb, Elai Davicioni, Shreyas Joshi, Aaron Dahmen, Roger Li, Brant A. Inman, Paras Shah, Iftach Chaplin, Jonathan Wright, Yair Lotan   +14 more
wiley   +1 more source

Bladder washing cytology in the initial evaluation of patients with neuro‐urological disorders: to do or not to do?

BJU International, EarlyView.
Objectives To evaluate if bladder washing cytology (BWC) provides a diagnostic benefit in the initial evaluation of patients with neuro‐urological disorders. Patients and Methods This prospective cross‐sectional study investigated a consecutive series of patients with lower urinary tract symptoms referred for neuro‐urological evaluation at our ...
Fabienne Lehner, Sarah Dugas, Veronika Birkhäuser, Oliver Gross, Lorenz Leitner, Ulrich Mehnert, Lara Stächele, Collene E. Anderson, Thomas M. Kessler   +8 more
wiley   +1 more source

Analysis of CacyBP/SIP, ERK1/2, and p38 Expression in Low‐ and High‐Grade Papillary Urothelial Carcinoma

Cancer Medicine
Background Papillary urothelial carcinoma (transitional cell carcinoma) is one of the most common malignant tumors of the urinary tract. Urothelial carcinomas are classified into muscle‐invasive and non‐muscle‐invasive types.
Natalia Domian, Grzegorz Młynarczyk, Irena Kasacka   +2 more
doaj   +1 more source

Diet and risk of bladder cancer: a systematic review of epidemiological evidence

BJU International, EarlyView.
Purpose Although tobacco use and occupational exposures are established risk factors for urothelial cancer (UC), the influence of dietary factors remains uncertain. We conducted a systematic review to synthesize evidence from prospective cohort studies examining associations between dietary exposures and UC incidence. Methods A comprehensive literature
Keiichiro Miyajima, Marcin Miszczyk, Navid Roessler, Shota Inoue, Paweł Rajwa, Akihiro Matsukawa, Fumihiko Urabe, Keiichiro Mori, Takafumi Yanagisawa, Pierre I. Karakiewicz, Jeremy Yuen‐Chun Teoh, Alberto Briganti, Lin Yang, Eva Schernhammer, Takahiro Kimura, Shahrokh F. Shariat   +15 more
wiley   +1 more source

Plasmacytoid subtype of urothelial carcinoma – Report of two rare cases and unusual features

Indian Journal of Pathology and Microbiology
Plasmacytoid urothelial carcinoma is a rare but aggressive subtype of urothelial carcinoma. The histopathologic mimics include plasmacytoma, metastasis from invasive lobular breast carcinoma, and gastric signet ring cell carcinoma.
Sagar Ranjan Tripathy, Pavithra Ayyanar, Deepak Kumar Das, Sandip Kumar Barik   +3 more
doaj   +1 more source