Results 161 to 170 of about 60,195 (236)

Multiplexed Immunofluorescent Characterization of T‐Cell and Myeloid Cell Populations Reveals Histologic Subtype Differences Within the Immunosuppressive Landscape of Human Basal Cell Carcinoma

open access: yesJournal of Cutaneous Pathology, Volume 53, Issue 7, Page 624-632, July 2026.
ABSTRACT Background Basal cell carcinomas (BCCs) are thought to reside within an immunosuppressed tumor microenvironment, but a detailed characterization of BCC‐associated immune cells was lacking. Methods Utilizing multiplex immunohistochemistry (IHC) (Vectra Polaris, Akoya Biosciences), we designed two staining panels, targeting either T cells (CD3 ...
Alan S. Shen   +6 more
wiley   +1 more source

Design and Synthesis of Pyrimidino[4,5‐d]Pyrimidine‐Based Compounds as Potent B‐RAF V600E Inhibitors

open access: yesChemMedChem, Volume 21, Issue 11, 15 June 2026.
Novel pyrimido[4,5‐d]pyrimidine‐based inhibitors selectively target B‐RAF V600E with nanomolar affinity and adopt distinct type‐II binding modes. Complementary cellular profiling reveals highly active analogs, underscoring the versatility of this chemotype and establishing it as a promising scaffold for the development of next‐generation kinase ...
Eleftheria A. Georgiou   +10 more
wiley   +1 more source

Immunohistochemistry-based risk stratification of upper tract urothelial carcinoma. [PDF]

open access: yesFront Oncol
He DL   +6 more
europepmc   +1 more source

Aberrant p53 fuels macrophage immunoregulatory polarization and refractory clinical outcome in urothelial carcinoma. [PDF]

open access: yesJ Immunother Cancer
Ding Y   +16 more
europepmc   +1 more source

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