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Chemical Studies on Ursolic Acid*
Journal of the American Pharmaceutical Association (Scientific ed.), 1953From ursolic acid, C29H46C29H46{−OH(C−2)−COOH(C−28), there was prepared acetyl ursolyl amide and acetyl ursolyl nitrile, both of which were reduced by lithium aluminum hydride to an ursolyl amine (C–28), C29H46{−OH−CH2NH2. By a similar reduction of ursonic acid oxime there was obtained an isomeric ursolyl amine (C–2), C29H46{−NH2−CH2OH. Methyl ursonate,
B Y, WU, L M, PARKS
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Solubilization of oleanolic acid and ursolic acid by cosolvency
Archives of Pharmacal Research, 1997Solubilities of oleanolic acid and ursolic acid in aqueous surfactant solutions, liquid polyethylene glycols (PEG), and solvents of various polarity were measured. The results showed that the solutes were slightly or moderately solubilized in the surfactant solutions and the liquid PEGs.
I J, Jin, Y I, Ko, Y M, Kim, S K, Han
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Modulation of angiogenic factors by ursolic acid
Biochemical and Biophysical Research Communications, 2008Investigations were carried out to understand the molecular basis of the effect of ursolic acid on angiogenesis by analysing its effects on the expression of modulators of angiogenesis by HUVECs in culture. Treatment with ursolic acid increased the expression of adhesion molecules such as E-selectin, CD-31 and I-CAM, upregulated angiogenic growth ...
M S, Kiran +3 more
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Ursolic Acid Inhibits Acid Sphingomyelinase in Intestinal Cells
Phytotherapy Research, 2012Ursolic acid (UA) has antiinflammatory and anticancer effects on mammalian cells. Increase in acid sphingomyelinase (SMase) is associated with several inflammatory diseases including inflammatory bowel diseases. The enzyme has become a target for drug discovery. The present study examined the roles of UA on acid SMase in intestinal cells. We found that
Ping, Zhang +2 more
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Oleanolic acid and ursolic acid stabilize liposomal membranes
Lipids, 1997AbstractThe effects of oleanolic acid (OA) and ursolic acid (UA) on the fluidity and stability of dipalmitoyl phosphatidylcholine (DPPC) liposomal membrane were monitored by measuring the fluorescence polarization of 1,6‐diphenyl‐1,3,5‐hexatriene labeled in the liposomal membrane and the leakage of calcein from the probe‐encapsulated liposomes.
S K, Han +4 more
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Oleanolic acid and ursolic acid: Research perspectives
Journal of Ethnopharmacology, 2005Oleanolic acid and ursolic acid are ubiquitous triterpenoids in plant kingdom, medicinal herbs, and are integral part of the human diet. During the last decade over 700 research articles have been published on their research, reflecting tremendous interest and progress in our understanding of these triterpenoids.
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Oxidation of ursolic acid by ozone
Chemistry of Natural Compounds, 2011Oxidation of methyl esters of ursolic and 3-acetoxyursolic acids by ozone formed products with a 12-oxo11S,13R-oxetane moiety on ring C.
O. B. Kazakova +4 more
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Ursolic acid: An anti‐ and pro‐inflammatory triterpenoid
Molecular Nutrition & Food Research, 2008AbstractThere is growing interest in the elucidation of the biological functions of triterpenoids, ubiquitously distributed throughout the plant kingdom, some of which are used as anticancer and anti‐inflammatory agents in Asian countries. Ursolic acid (UA), a natural pentacyclic triterpenoid carboxylic acid, is the major component of some traditional ...
Yasutaka, Ikeda +2 more
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