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A pH-Responsive Hydrogel for the Oral Delivery of Ursolic Acid: A Pentacyclic Triterpenoid Phytochemical. [PDF]

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Gutierrez CD, Aranzábal RL, Lechuga AM, Serrano CA, Meza F, Elvira C, Gallardo A, Ludeña MA.   +7 more
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Ursolic acid nanoparticles for glioblastoma therapy

Nanomedicine: Nanotechnology, Biology and Medicine, 2023
Glioblastoma multiforme (GBM) is the most common and fatal primary tumor in the central nervous system (CNS). The effect of chemotherapy of GBM is limited due to the existence of blood-brain barrier (BBB). The aim of this study is to develop self-assembled nanoparticles (NPs) of ursolic acid (UA) for GBM treatment.UA NPs were synthesized by solvent ...
Yong, Li, Linyao, Zhao, Qingyu, Zhao, Youdong, Zhou, Long, Zhou, Ping, Song, Baohui, Liu, Qianxue, Chen, Gang, Deng   +8 more
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Chemical Studies on Ursolic Acid*

Journal of the American Pharmaceutical Association (Scientific ed.), 1953
From ursolic acid, C29H46C29H46{−OH(C−2)−COOH(C−28), there was prepared acetyl ursolyl amide and acetyl ursolyl nitrile, both of which were reduced by lithium aluminum hydride to an ursolyl amine (C–28), C29H46{−OH−CH2NH2. By a similar reduction of ursonic acid oxime there was obtained an isomeric ursolyl amine (C–2), C29H46{−NH2−CH2OH. Methyl ursonate,
B Y, WU, L M, PARKS
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Oleanolic acid and ursolic acid stabilize liposomal membranes

Lipids, 1997
AbstractThe effects of oleanolic acid (OA) and ursolic acid (UA) on the fluidity and stability of dipalmitoyl phosphatidylcholine (DPPC) liposomal membrane were monitored by measuring the fluorescence polarization of 1,6‐diphenyl‐1,3,5‐hexatriene labeled in the liposomal membrane and the leakage of calcein from the probe‐encapsulated liposomes.
S K, Han, Y I, Ko, S J, Park, I J, Jin, Y M, Kim   +4 more
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Ursolic Acid Inhibits Acid Sphingomyelinase in Intestinal Cells

Phytotherapy Research, 2012
Ursolic acid (UA) has antiinflammatory and anticancer effects on mammalian cells. Increase in acid sphingomyelinase (SMase) is associated with several inflammatory diseases including inflammatory bowel diseases. The enzyme has become a target for drug discovery. The present study examined the roles of UA on acid SMase in intestinal cells. We found that
Ping, Zhang, Yajun, Cheng, Rui-Dong, Duan   +2 more
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Pharmacology of oleanolic acid and ursolic acid

Journal of Ethnopharmacology, 1995
Oleanolic acid and ursolic acid are triterpenoid compounds that exist widely in food, medicinal herbs and other plants. This review summarizes the pharmacological studies on these two triterpenoids. Both oleanolic acid and ursolic acid are effective in protecting against chemically induced liver injury in laboratory animals.
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Oleanolic acid and ursolic acid: Research perspectives

Journal of Ethnopharmacology, 2005
Oleanolic acid and ursolic acid are ubiquitous triterpenoids in plant kingdom, medicinal herbs, and are integral part of the human diet. During the last decade over 700 research articles have been published on their research, reflecting tremendous interest and progress in our understanding of these triterpenoids.
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Ursolic acid regulates high glucose-induced apoptosis

Free Radical Research, 2007
A high concentration of glucose has been implicated as a causal factor in initiation and progression of diabetic complications and there is evidence to suggest that hyperglycemia increases the production of free radicals and oxidative stress. Therefore, compounds that scavenge reactive oxygen species (ROS) may confer regulatory effects on high glucose ...
Chang Joo, Oh, In Sup, Kil, Chan Ik, Park, Chae Ha, Yang, Jeen-Woo, Park   +4 more
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Modulation of angiogenic factors by ursolic acid

Biochemical and Biophysical Research Communications, 2008
Investigations were carried out to understand the molecular basis of the effect of ursolic acid on angiogenesis by analysing its effects on the expression of modulators of angiogenesis by HUVECs in culture. Treatment with ursolic acid increased the expression of adhesion molecules such as E-selectin, CD-31 and I-CAM, upregulated angiogenic growth ...
M S, Kiran, R I, Viji, V B, Sameer Kumar, P R, Sudhakaran   +3 more
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