Using a novel zebrafish‐based inflammatory screening strategy, we screened and identified 18β‐glycyrrhetinic acid (18β‐GA) as a promising anti‐inflammatory candidate. We uncover a microglial mTOR–autophagy–NLRP3 axis that constitutes the mechanistic core of 18β‐GA–mediated neuroprotection.
Hua Gan +11 more
wiley +1 more source
Chinese Medicines Induce Cell Death: The Molecular and Cellular Mechanisms for Cancer Therapy [PDF]
published_or_final_versio
CHEUNG, F +7 more
core +3 more sources
Ursolic Acid Alleviates Orchitis via Modulating Ferroptosis in Peritubular Myoid Cells of Testis
Ursolic acid modulates key ferroptosis‐related pathways in the peritubular myoid cells of the testis in forest musk deer. ABSTRACT Chronic stress adversely affects reproductive health, increasing susceptibility to pathologies such as orchitis. Additionally, the maintenance of iron homeostasis is essential for preserving the function of the testicles ...
Yang Wang +11 more
wiley +1 more source
Cornus mas and Cornus Officinalis—Analogies and Differences of Two Medicinal Plants Traditionally Used [PDF]
Among 65 species belonging to the genus Cornus only two, Cornus mas L. and Cornus officinalis Sieb. et Zucc. (Cornaceae), have been traditionally used since ancient times.
Czerwińska, Monika E. +1 more
core +1 more source
Determination of ursolic acid and ursolic acid lactone in the leaves of Eucalyptus tereticornis by HPLC [PDF]
A simple isocratic HPLC method has been developed for the simultaneous quantification of two bioactive triterpenes, ursolic acid and ursolic acid lactone in E. tereticornis leaves. Samples were analyzed on RP-18 (4.6 × 250 mm, 5 µm) column with methanol and water acidified to pH 3.5 with TFA (88:12) at 210 nm.
Maurya, Anupam +1 more
openaire +3 more sources
The review critically evaluated and compared the selected superfruit phytochemistry, their bioactive composition and the key health benefits majorly emphasizing the antioxidant potential. It has highlighted the translational challenges in formulating functional foods by addressing the issues related to delivery system, bioavailability mechanism and the
Sharath Kumar Nagaraja +3 more
wiley +1 more source
Constituintes químicos de Hyptidendron canum (Pohl ex Benth.) R. Harley (Lamiaceae)
Chemical investigation of Hyptidendron canum stems resulted in the isolation of betulinic, ursolic and euscaphic acids. From the leaves were isolated 3β-O-β-galactopiranosilsitosterol, ursolic aldehyde, and mixtures of maslinic acid and 2α-hydroxyursolic
Geralda de Fátima Lemes +2 more
doaj +1 more source
Detection and Quantification of Glucuronidation of Ursolic Acid (UA) in Human Liver Microsomes (HLMs). [PDF]
https://scholarscompass.vcu.edu/uresposters/1270/thumbnail ...
Gerk, Philip M., Tolliboeva, Kamola
core +1 more source
Measuring oxidative DNA damage and DNA repair using the yeast comet assay [PDF]
Chromosomal DNA damage can be a result of several processes and agents of endogenous or exogenous origin. These cause strand breaks or oxidized bases that lead to strand breaks, which relax the normally supercoiled genomic DNA and increase its ...
Collins +13 more
core +1 more source
Enhancement of Platelet Aggregation by Ursolic Acid and Oleanolic Acid [PDF]
The pentacyclic triterpenoid ursolic acid (UA) and its isomer oleanolic acid (OA) are ubiquitous in food and plant medicine, and thus are easily exposed to the population through natural contact or intentional use. Although they have diverse health benefits, reported cardiovascular protective activity is contentious. In this study, the effect of UA and
Kim, Mikyung +2 more
openaire +2 more sources

