Results 31 to 40 of about 12,996 (224)

Therapeutic potentials of Crataegus azarolus var. eu- azarolus Maire leaves and its isolated compounds

BMC Complementary and Alternative Medicine, 2017
Background Hyperglycemia is a complicated condition accompanied with high incidence of infection and dyslipidemia. This study aimed to explore the phyto-constituents of Crataegus azarolus var.
Eman Abu-Gharbieh, Naglaa Gamil Shehab
doaj   +1 more source

Regulation of mitogen-activated protein kinase signaling pathway and proinflammatory cytokines by ursolic acid in murine macrophages infected with Mycobacterium avium

Infectious Disease Reports, 2020
Mycobacterium avium, one of the closest relatives of Mycobacterium tuberculosis (MTB), offers an advantage in studying MTB because of its tuberculosis-like effect in humans and host immune tolerance.
Dian Ayu Eka Pitaloka, Andrea M. Cooper, Aluicia Anita Artarini, Elin Yulinah Sukandar, Sophi Damayanti   +4 more
doaj   +1 more source

Differential Anti-Proliferative and Anti-Migratory Activities of Ursolic Acid, 3-O-Acetylursolic Acid and Their Combination Treatments with Quercetin on Melanoma Cells

Biomolecules, 2020
We evaluate how 3-acetylation modulates the in vitro activity of ursolic acid in melanoma cells alone or in combination treatments with quercetin. Anti-proliferative studies on A375 cells and adult human dermal fibroblasts included analyses on cell cycle
Aljawharah AlQathama, Luying Shao, Ammar Bader, Proma Khondkar, Simon Gibbons, Jose M Prieto   +5 more
doaj   +1 more source

Investigating the combined effect of ursolic acid and alpelisib on inhibiting cell proliferation and the expression of HIF1α on 4T1 breast cancer cell line [PDF]

Journal of Research in Applied and Basic Medical Sciences, 2023
Background & Aims:  Alpelisib and Ursolic acid are two compounds that have been shown to have potential as anti-cancer agents. Alpelisib is a selective inhibitor of the PI3K pathway, while Ursolic acid is a natural pentacyclic triterpene compound found ...
Erfan Sheikhi, Mahmoudreza Aghamaali, Shabnam Babataheri   +2 more
doaj  

Extraction of ursolic acid in Cornus officinalis by fermentation combined with ultrasonic-assisted technique

浙江大学学报. 农业与生命科学版, 2009
The optimum extraction process of ursolic acid from the fermentation product of Cornus officinalis was screened by the aid of ultrasonic, and the yield of ursolic acid was monitored by HPLC techniques.
XU Bai-tao, HE Guo-qing, LI Xin-hong, YU Hai-ning, SHEN Sheng-rong   +4 more
doaj   +1 more source

Ursolic Acid as a Trypanocidal Constituent in Rosemary.

Biological and Pharmaceutical Bulletin, 2002
The MeOH extract of the leaves of rosemary (Rosmarinus officinalis L.) completely inhibited the motility of cultured epimastigotes of Trypanosoma cruzi at the concentration of 2 mg/ml after 2 h of incubation. Activity-guided fractionation of the MeOH extract has resulted in the isolation of three triterpene acids, betulinic, oleanolic and ursolic acids.
Abe, Fumiko, Yamauchi, Tatsuo, Nagao, Tsuneatsu, Kinjo, Junei, Okabe, Hikaru, Higo, Hiroo, Akahane, Hiroshige   +6 more
openaire   +3 more sources

Ursolic Acid Induces Beneficial Changes in Skeletal Muscle mRNA Expression and Increases Exercise Participation and Performance in Dogs with Age-Related Muscle Atrophy

Animals
Muscle atrophy and weakness are prevalent and debilitating conditions in dogs that cannot be reliably prevented or treated by current approaches. In non-canine species, the natural dietary compound ursolic acid inhibits molecular mechanisms of muscle ...
Scott M. Ebert, Celine S. Nicolas, Paul Schreiber, Jaime G. Lopez, Alan T. Taylor, Andrew R. Judge, Sarah M. Judge, Blake B. Rasmussen, John J. Talley, Christophe A. Rème, Christopher M. Adams   +10 more
doaj   +1 more source

The potential chemo preventive effect of ursolic acid isolated from Paulownia tomentosa, against N-diethylnitrosamine: initiated and promoted hepatocarcinogenesis

Heliyon, 2019
The present study discusses the isolation of ursolic acid from the chloroform extract of Paulownia tomentosa (Thunb) Steud fruits and its cytotoxic effect has been assessed in-vitro was performed in different cells lines (A-549, MCF-7, HepG2) and in-vivo
Sanaa A. Ali, Nabaweya A. Ibrahim, Magdy M.D. Mohammed, Seham El-Hawary, Esraa A. Refaat   +4 more
doaj   +1 more source

A Computational Strategy for Identifying Self‐Assembling Food‐Derived Molecules for Antiparasitic Nanotherapy

Advanced Science, EarlyView.
An integrated computational screening strategy identified ursolic acid (UA) and 18β‐glycyrrhetinic acid (18βGA) as a self‐assembling food‐derived molecular pair. The resulting carrier‐free nanoparticles (UA‐18βGA) showed synergistic antiparasitic activity, reduced combined toxicity, and host‐protective anti‐inflammatory effects in zebrafish and murine ...
Shenye Qu, Ting Wang, Jietao Liu, Jiacheng Qin, Bin Yang, Yihang Liu, Pengfei Li, Gaoxue Wang, Fei Ling   +8 more
wiley   +1 more source

Effects of Ursolic Acid and its Analogues on Soybean 15-Lipoxygenase Activity and the Proliferation Rate of A human Gastric Tumour Cell Line

Mediators of Inflammation, 1994
The authors have previously isolated and purified ursolic acid from heather flowers (Calluna vulgarts). This terpene was found to inhibit HL-60 leukaemic cell proliferation and arachidonic acid oxidative metabolism in various cell species. The effects of
D. Es-Saady, A. Najid, A. Simon, Y. Denizot, A. J. Chulia, C. Delage   +5 more
doaj   +1 more source