Results 21 to 30 of about 10,207 (185)

The Metabolic Changes of Artesunate and Ursolic Acid on Syrian Golden Hamsters Fed with the High-Fat Diet

Molecules, 2020
Artesunate was well known as an antimalarial drug. Our previous research found that it has hypolipidemia effects in rabbits fed with a high-fat diet, especially combined with ursolic acid.
Shichen Pu, Yumin Liu, Shan Liang, Pin Liu, Hongmei Qian, Qian Wu, Yuliang Wang   +6 more
doaj   +1 more source

Ursolic acid in health and disease

The Korean Journal of Physiology & Pharmacology, 2018
Ursolic acid (UA) is a natural triterpene compound found in various fruits and vegetables. There is a growing interest in UA because of its beneficial effects, which include anti-inflammatory, anti-oxidant, anti-apoptotic, and anti-carcinogenic effects.
Seo, Dae Yun, Lee, Sung Ryul, Heo, Jun-Won, No, Mi-Hyun, Rhee, Byoung Doo, Ko, Kyung Soo, Kwak, Hyo-Bum, Han, Jin   +7 more
openaire   +2 more sources

Therapeutic potentials of Crataegus azarolus var. eu- azarolus Maire leaves and its isolated compounds

BMC Complementary and Alternative Medicine, 2017
Background Hyperglycemia is a complicated condition accompanied with high incidence of infection and dyslipidemia. This study aimed to explore the phyto-constituents of Crataegus azarolus var.
Eman Abu-Gharbieh, Naglaa Gamil Shehab
doaj   +1 more source

Enhancement of Platelet Aggregation by Ursolic Acid and Oleanolic Acid [PDF]

Biomolecules & Therapeutics, 2014
The pentacyclic triterpenoid ursolic acid (UA) and its isomer oleanolic acid (OA) are ubiquitous in food and plant medicine, and thus are easily exposed to the population through natural contact or intentional use. Although they have diverse health benefits, reported cardiovascular protective activity is contentious. In this study, the effect of UA and
Kim, Mikyung, Han, Chang-ho, Lee, Moo-Yeol   +2 more
openaire   +2 more sources

Regulation of mitogen-activated protein kinase signaling pathway and proinflammatory cytokines by ursolic acid in murine macrophages infected with Mycobacterium avium

Infectious Disease Reports, 2020
Mycobacterium avium, one of the closest relatives of Mycobacterium tuberculosis (MTB), offers an advantage in studying MTB because of its tuberculosis-like effect in humans and host immune tolerance.
Dian Ayu Eka Pitaloka, Andrea M. Cooper, Aluicia Anita Artarini, Elin Yulinah Sukandar, Sophi Damayanti   +4 more
doaj   +1 more source

Ursolic acid inhibits superoxide production in activated neutrophils and attenuates trauma-hemorrhage shock-induced organ injury in rats.

PLoS ONE, 2014
Neutrophil activation is associated with the development of organ injury after trauma-hemorrhagic shock. In the present study, ursolic acid inhibited the superoxide anion generation and elastase release in human neutrophils.
Tsong-Long Hwang, Hsin-I Shen, Fu-Chao Liu, Hsin-I Tsai, Yang-Chang Wu, Fang-Rong Chang, Huang-Ping Yu   +6 more
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Differential Anti-Proliferative and Anti-Migratory Activities of Ursolic Acid, 3-O-Acetylursolic Acid and Their Combination Treatments with Quercetin on Melanoma Cells

Biomolecules, 2020
We evaluate how 3-acetylation modulates the in vitro activity of ursolic acid in melanoma cells alone or in combination treatments with quercetin. Anti-proliferative studies on A375 cells and adult human dermal fibroblasts included analyses on cell cycle
Aljawharah AlQathama, Luying Shao, Ammar Bader, Proma Khondkar, Simon Gibbons, Jose M Prieto   +5 more
doaj   +1 more source

Extraction of ursolic acid in Cornus officinalis by fermentation combined with ultrasonic-assisted technique

浙江大学学报. 农业与生命科学版, 2009
The optimum extraction process of ursolic acid from the fermentation product of Cornus officinalis was screened by the aid of ultrasonic, and the yield of ursolic acid was monitored by HPLC techniques.
XU Bai-tao, HE Guo-qing, LI Xin-hong, YU Hai-ning, SHEN Sheng-rong   +4 more
doaj   +1 more source

Investigating the combined effect of ursolic acid and alpelisib on inhibiting cell proliferation and the expression of HIF1α on 4T1 breast cancer cell line [PDF]

Journal of Research in Applied and Basic Medical Sciences, 2023
Background & Aims:  Alpelisib and Ursolic acid are two compounds that have been shown to have potential as anti-cancer agents. Alpelisib is a selective inhibitor of the PI3K pathway, while Ursolic acid is a natural pentacyclic triterpene compound found ...
Erfan Sheikhi, Mahmoudreza Aghamaali, Shabnam Babataheri   +2 more
doaj  

Ursolic Acid Induces Beneficial Changes in Skeletal Muscle mRNA Expression and Increases Exercise Participation and Performance in Dogs with Age-Related Muscle Atrophy

Animals
Muscle atrophy and weakness are prevalent and debilitating conditions in dogs that cannot be reliably prevented or treated by current approaches. In non-canine species, the natural dietary compound ursolic acid inhibits molecular mechanisms of muscle ...
Scott M. Ebert, Celine S. Nicolas, Paul Schreiber, Jaime G. Lopez, Alan T. Taylor, Andrew R. Judge, Sarah M. Judge, Blake B. Rasmussen, John J. Talley, Christophe A. Rème, Christopher M. Adams   +10 more
doaj   +1 more source