Results 91 to 100 of about 5,933,393 (275)
FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer
FEBS Letters, EarlyView.Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani +4 more
wiley +1 more source
Journal of Comparative Effectiveness ResearchIn this update, we discuss the implementation progress of the Medicare Drug Price Negotiation Program, with particular focus on the second round of negotiations for 15 additional Part D drugs; explore the role of health technology assessment in US ...
Sreeram V Ramagopalan +1 more
doaj +1 more source
The global gas transit: new supply chains
Проблемы постсоветского пространстваThe aggravation of relations between Russia and Western countries in early 2022 has marked the formation of new supply chains for energy resources, particularly gas exports.
S. S. Zhiltsov
doaj +1 more source
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
Policy of Western States in Central Asia: The Role of Rare-Earth Metals
Проблемы постсоветского пространстваAfter the collapse of the USSR, the policy of the Western states towards Central Asia was focused on the issues linked to the expansion of trade and economic relations, gaining access to hydrocarbon resources of the regional countries and organizing ...
S. S. Zhiltsov
doaj +1 more source
Estimated COVID-19 IFR was dozen times higher than flu IFR, whereas COVID-19 CFR was several dozen times higher than flu CFR in USA [PDF]
, 2020 Piotr Rieske
openalex +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Improved protein sample separation using GenScript’s SurePAGETM Bis-Tris gels
BioTechniques, 2017 USA GenScript, NJ Piscataway
doaj +1 more source