Results 101 to 110 of about 12,956,457 (322)
FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
Eurasian Call for the Project «Integration of Integrations»
Управленческое консультирование, 2018 In today’s rapidly changing world integration is one of the possibilities of sustainable development of countries, and in view of the growing role of large state associations, increasing the likelihood of integration project.
Nikolai Maratovich Mezhevich
doaj
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
CONSEQUENCES OF THE JULY (2025) EU–US AGREEMENT FOR GERMANY’S ECONOMIC AND POLITICAL SPACE
Научно-аналитический вестник Института Европы РАНThe article analyzes the implications for Germany’s economic Standort of the agreements reached between the European Union and the United States on July 27, 2025, in Scotland. European Commission President Ursula von der Leyen and U.S.
Vladislav B. Belov
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Integration of circadian and hypoxia signaling via non‐canonical heterodimerization
FEBS Letters, EarlyView.CLOCK, BMAL1, and HIFs are basic helix‐loop‐helix and Per‐Arnt‐Sim domain (bHLH‐PAS) proteins, which function as transcription factors. bHLH‐PAS proteins are designated in two classes. Many class I proteins are regulated by environmental signals via their PAS domains, but such signals have not been identified for all.
Sicong Wang, Katja A. Lamia
wiley +1 more source
Epidemiology of Cryptosporidiosis, New York City, New York, USA, 1995–20181 [PDF]
, 2020 Lisa Alleyne +12 more
openalex +1 more source
Fighting Terrorism in an Electronic Age: Does the Patriot Act Unduly Compromise Our Civil Liberties? [PDF]
, 2006 The USA PATRIOT Act is tremendously controversial, both lauded by law enforcement and decried by civil liberties groups. This iBrief considers two of the Act\u27s communications monitoring provisions, concluding that each compromises civil liberties to a
Raab, Christopher P.
core +1 more source
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source