Results 71 to 80 of about 8,836,721 (323)

Taurine promotes glucagon‐like peptide‐1 secretion in enteroendocrine L cells

open access: yesFEBS Letters, EarlyView.
Taurine, a sulfur‐containing amino acid, is likely taken up by enteroendocrine L cells via the taurine transporter. This process increases the levels of cytosolic ATP. The increase in intracellular Ca2+ concentrations and glucagon‐like peptide‐1 secretion through membrane depolarization is caused by the closure of ATP‐sensitive potassium channels ...
Yuri Osuga   +6 more
wiley   +1 more source

What is Usability? A Characterization based on ISO 9241-11 and ISO/IEC 25010 [PDF]

open access: yesarXiv, 2015
According to Brooke [1] "Usability does not exist in any absolute sense; it can only be defined with reference to particular contexts." That is, one cannot speak of usability without specifying what that particular usability is characterized by.
arxiv  

The multiple roles of the NlpC_P60 peptidase family in mycobacteria – an underexplored target for antimicrobial drug discovery

open access: yesFEBS Letters, EarlyView.
The NlpC_P60 superfamily of peptidases is recognised by its key role in bacterial cell wall homeostasis. Recently, studies have also described the involvement of NlpC_P60‐like enzymes in bacterial competitive mechanisms and pathogenesis across several lineages.
Catharina dos Santos Silva   +1 more
wiley   +1 more source

Novel Interaction Cost Analysis Applied to Bank Charges Calculator

open access: yesComputers, 2019
This paper presents an online calculator for bank charges, motivated by information asymmetry in the market for payment accounts. The calculator provides users with a personalized list of the most suitable bank accounts based on required services and ...
Ivan Soukal
doaj   +1 more source

A Generic Cognitive Dimensions Questionnaire to Evaluate the Usability of Security APIs [PDF]

open access: yesarXiv, 2017
Programmers use security APIs to embed security into the applications they develop. Security vulnerabilities get introduced into those applications, due to the usability issues that exist in the security APIs. Improving usability of security APIs would contribute to improve the security of applications that programmers develop. However, currently there
arxiv  

Making tau amyloid models in vitro: a crucial and underestimated challenge

open access: yesFEBS Letters, EarlyView.
This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley   +1 more source

Towards Enhanced Usability of IT Security Mechanisms - How to Design Usable IT Security Mechanisms Using the Example of Email Encryption [PDF]

open access: yesInternational Journal On Advances in Security, volume 6, number 1&2, pp. 78-87 ISSN 1942-2636, 2013, 2015
Nowadays, advanced security mechanisms exist to protect data, systems, and networks. Most of these mechanisms are effective, and security experts can handle them to achieve a sufficient level of security for any given system. However, most of these systems have not been designed with focus on good usability for the average end user.
arxiv  

Expected usability is not a valid indicator of experienced usability

open access: yesPeerJ Computer Science, 2015
Usability is a core construct of website evaluation and inherently defined as interactive. Yet, when analysing first impressions of websites, expected usability, i.e., before use, is of interest. Here we investigate to what extend ratings of expected usability are related to (a) experienced usability, i.e., ratings after use, and (b) objective ...
Thielsch, Meinald T.   +2 more
openaire   +4 more sources

Unraveling Mycobacterium tuberculosis acid resistance and pH homeostasis mechanisms

open access: yesFEBS Letters, EarlyView.
Mycobacterium tuberculosis exhibits a remarkable resilience to acid stress. In this Review, we discuss some of the molecular mechanisms and metabolic pathways used by the tubercle bacilli to adapt and resist host‐mediated acid stress. Mycobacterium tuberculosis (Mtb) is a successful pathogen that has developed a variety of strategies to survive and ...
Janïs Laudouze   +3 more
wiley   +1 more source

Usability of Interfaces

open access: yes, 2012
Adequate usability is important because it is a characteristic of product quality that leads to improving product acceptability, increasing user satisfaction, improving product reliability and it is also financially beneficial to companies. Such benefit can be seen from two points of view, one related with workers’ productivity (less training time and ...
Isabel L. Nunes, Mário Simões-Marques
openaire   +4 more sources

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