Results 161 to 170 of about 119,123 (311)

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Development and usability evaluation of training equipment for syringe-based wound irrigation education. [PDF]

BMC Med Educ
Han J, Yang B, Lee K.
europepmc   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Quality and Usability Evaluation of U.S. Clinical Informatics Fellowship Websites. [PDF]

Appl Clin Inform
You JG, Yuan J, Gupta G, Mitragotri S, Shannon K, Hassan A, Goff A, He S, Kim E.   +8 more
europepmc   +1 more source

Nutzung von Aufgabenmodellen zur Usability-Evaluation – Konzept und Erfahrungen

, 2009
Die Usability-Evaluation von Software kann mit unterschiedlichen Methoden durchgeführt werden, abhängig vom geforderten Umfang der Ergebnisse sowie den zu investierenden Mitteln.
Dabbert, Julian, Szwillus, Gerd
core  

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Usability Evaluation and Perceived Performance of the MoonWalking^® Insole in Safety Footwear. [PDF]

Sensors (Basel)
Castro-Martins P, Marques A, Pinto-Coelho L, Vaz M.   +3 more
europepmc   +1 more source

Methoden für Usability Evaluation auf Basis von Aufgabenmodellen

, 2007
Die erfolgreiche Entwicklung interaktiver Systeme setzt die Einbeziehung des Nutzers in alle Phasen der Entwicklung voraus. Ausgehend von einem eigenen Ansatz zur modellbasierten Softwareentwicklung und dem Werkzeug ReModEl (Remote Model based Usability ...
Forbrig, Peter, Propp, Stefan, Buchholz, Gregor   +2 more
core  

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Usability Evaluation of the Karafs Application: A Qualitative Study Using the Think-Aloud Method. [PDF]

Health Sci Rep
Bohlouly F, Kheirdoust A, Ghaddaripouri K, Sheibani R, Mazaheri Habibi MR.   +4 more
europepmc   +1 more source