Results 151 to 160 of about 119,123 (311)
Usability issues with security of electronic mail
, 2007 This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.This thesis shows that human factors can have a large and direct impact on security, not only on the user’s satisfaction, but also on the level of security ...
DeWitt, Alexander John Anthony George
core
FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source
Ubiquitination of secretory granules promotes their crinophagic degradation in Drosophila
FEBS Letters, EarlyView.Ubiquitination of secretory granules in Drosophila larval salivary glands is a critical molecular trigger for crinophagy, the lysosomal degradation of unreleased, or low‐quality granules. The E3 ubiquitin ligase Cnot4 is recruited to the surface of secretory granules to induce crinophagy.
Tamás Csizmadia +6 more
wiley +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
, 2013 The demand for good usability has become indisputable as usable products are more profitable, secure and enhance the reputation of its producing company. For many applications abstract usability problems like "Users have problems using the online shop"
Seebach, Oliver
core
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Falsification testing for usability inspection method assessment
, 2004 We need more reliable usability inspection methods (UIMs), but assessment of UIMs has been unreliable [5]. We can only reliably improve UIMs if we have more reliable assessment.
Cockton, Gilbert +5 more
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Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source
Usability evaluation of Alerta Alcohol 2.0: an eHealth game to prevent adolescent alcohol consumption. [PDF]
J Public Health (Oxf)Fernández-León P +2 more
europepmc +1 more source
, 2002 There is a need for tools that help developers evaluate the usability of digital library interfaces. The potential for using Claims Analysis to help developers in this way has been investigated in three linked case studies.
Keith, S +7 more
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