Results 101 to 110 of about 2,904,443 (296)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

The Effectiveness of Family Behavior Therapy for Adolescent Behavioral and Substance Misuse Complications: A Meta-Analysis

open access: yes, 2018
A number of systematic and meta-analytic reviews have suggested that family behavior therapy may be effective in decreasing adolescent behavioral and substance misuse.
Lyn, Robyn L, Exume, Torica L
core  

The influence of land use and mobility policy on travel behavior : a comparative case study of Flanders and the Netherlands [PDF]

open access: yes, 2015
Numerous transportation studies have indicated that the local built environment can have an important effect on travel behavior; people living in suburban neighborhoods travel more by car than people living in urban neighborhoods. In this paper, however,
De Vos, Jonas, Jonas De Vos, Vos, Jonas
core   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Application Theory of Planned Behavior: Determinants of Behavior to Use Personal Protective Equipment among Tobacco Farmers in Temanggung, Central Java: A Multilevel Analysis

open access: yes, 2020
Background: Tobacco farmers has the risk of being exposed by wet nicotine during har­vest­ing tobacco leaves or is often called as Green Tobacco Sick­ness (GTS).
Rahardjo, Setyo Sri   +2 more
core  

Housing instability and economic insecurity across the continuum of active substance use, treatment, and recovery among women involved in the criminal legal system

open access: yesWomen's Health
Background: Prior research on the widespread housing instability, such as homelessness, and economic insecurity, such as difficulties gaining employment, faced by women with a history of opioid use disorder (OUD) highlights the need to explore the impact
Emma M. Skogseth   +5 more
doaj   +1 more source

Determinants of helmet use among health-care providers in urban India: Leveraging the theory of planned behavior

open access: yesJournal of Education and Health Promotion, 2019
CONTEXT: Wearing helmet during road traffic accidents among motorcycle riders decreases the likelihood of death by 39%. The theory of planned behavior (TPB), a psychological model helps to explain the failure in helmet usage, by assuming a causal chain ...
M N Shruthi, Anand D Meundi, D Sushma
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Sexual and Drug Use Behavior in Perinatally HIV-Infected Youth: Mental Health and Family Influences

open access: yes, 2009
Objective: As perinatally HIV-infected (PHIV+) youth enter adolescence, they are at high risk for poor behavioral and health outcomes. This study examines relationships between youth mental health problems and sexual and substance use risk behavior, the ...
McKay, M.   +17 more
core   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

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