Results 91 to 100 of about 463,209 (335)

P‐glycoprotein modulates the fluidity gradient of the plasma membrane of multidrug resistant CHO cells

FEBS Letters, EarlyView.
To explore the impact of the overexpression of the multidrug‐transporter P‐glycoprotein (ABCB1) on membrane fluidity, we compared the transversal gradient of mobility and microviscosity in plasma membranes of drug‐sensitive Chinese hamster ovary cells (AuxB1) and their multidrug‐resistant derivatives (B30) using the fluorescent n‐(9‐anthroyloxy) fatty ...
Roger Busche, John R. Riordan, Burkhard Tümmler   +2 more
wiley   +1 more source

Evolutionary interplay between viruses and R‐loops

FEBS Letters, EarlyView.
Viruses interact with specialized nucleic acid structures called R‐loops to influence host transcription, epigenetic states, latency, and immune evasion. This Perspective examines the roles of R‐loops in viral replication, integration, and silencing, and how viruses co‐opt or avoid these structures.
Zsolt Karányi, Zita Képes, Zoltán Szabó, Eszter Csoma, Lóránt Székvölgyi   +4 more
wiley   +1 more source

User Experience Research pada Google Maps dengan Penambahan Fitur Driving Behavior Menggunakan Metode User Centered Design

Jurnal Informatika dan Multimedia
Kecelakaan lalu lintas merupakan penyebab kematian nomor dua di dunia. Indonesia menduduki peringkat kedua penyebab kematian tertinggi akibat kecelakaan lalu lintas. Statistik kecelakaan lalu lintas menunjukkan bahwa sebagian besar kecelakaan disebabkan
Novitasari
doaj   +1 more source

Penerapan Metode UCD (User Centered Design) Pada E-Commerce Putri Intan Shop Berbasis Web

Jurnal Teknologi dan Sistem Informasi, 2017
Pertumbuhan pesat pangsa pasar e-commerce di Indonesia memang sudah tidak bisa diragukan lagi. Dengan jumlah pengguna internet yang mencapai angka 82 juta orang atau sekitar 30% dari total penduduk di Indonesia, pasar e-commerce menjadi tambang emas yang
Intan Sandra Yatana Saputri, Mardhiah Fadhli, Ibnu Surya   +2 more
doaj   +1 more source

iPlus a User-Centered Methodology for Serious Games Design

Applied Sciences, 2020
Standard video games are applications whose development process often follows a traditional software methodology. Serious Games (SGs) are a tool with an immensely positive impact and great success.
Mayra Carrión-Toro, Marco Santorum, Patricia Acosta-Vargas, Jose Aguilar, María Pérez   +4 more
doaj   +1 more source

Disruption of SETD3‐mediated histidine‐73 methylation by the BWCFF‐associated β‐actin G74S mutation

FEBS Letters, EarlyView.
The β‐actin G74S mutation causes altered interaction of actin with SETD3, reducing histidine‐73 methylation efficiency and forming two distinct actin variants. The variable ratio of these variants across cell types and developmental stages contributes to tissue‐specific phenotypical changes. This imbalance may impair actin dynamics and mechanosensitive
Anja Marquardt, Marcus S. Münchhoff, Jacqueline Krohn, Philip M. Palarz, Manuel H. Taft, Johannes N. Greve, Nataliya Di Donato, Falk F. R. Buettner, Dietmar J. Manstein   +8 more
wiley   +1 more source

User centered design to incorporate predictive models for type 2 Diabetes screening and management into professional decision support tools: preliminary results [PDF]

, 2015
Type 2 Diabetes screening and risk stratification tools could benefit from the incorporation of predictive systems based on computer modelling. The adoption of User Centered Design techniques is fundamental in order to integrate these systems in an ...
Arredondo Waldmeyer, Maria Teresa, Cancela González, Jorge, Fico, Giuseppe, Hernández González, Liss   +3 more
core   +1 more source

Circulating histones as clinical biomarkers in critically ill conditions

FEBS Letters, EarlyView.
Circulating histones are emerging as promising biomarkers in critical illness due to their diagnostic, prognostic, and therapeutic potential. Detection methods such as ELISA and mass spectrometry provide reliable approaches for quantifying histone levels in plasma samples.
José Luis García‐Gimenez, Juan Carlos Ruiz‐Rodríguez, Ricard Ferrer, Raquel Durá, Antonio Artigas, Iván Bajaña, David Bolado López de Andujar, Irene Cánovas‐Cervera, Adrián Ceccato, Luis Chiscano‐Camón, Elena Climent‐Martinez, Georgia García Fernández, Gemma Goma, Verónica Monforte, Beatriz Quevedo‐Sánchez, Adolf Ruiz‐Sanmartín, Antonio Sierra‐Rivera, Nieves Carbonell Monleón   +17 more
wiley   +1 more source

Preferred Workflows for Syndromic Surveillance Systems [PDF]

, 2009
Workflows are a sequence of information processing operations that people carry out to meet certain in-formational goals [1]. Using various user-centered design (UCD) techniques we uncovered the workflows that epidemiologists wished to follow when using ...
Guthrie, Glenn, Moore, Kieran, Vinson, Norman G.   +2 more
core  

Insights into pegRNA design from editing of the cardiomyopathy‐associated phospholamban R14del mutation

FEBS Letters, EarlyView.
This study reveals how prime editing guide RNA (pegRNA) secondary structure and reverse transcriptase template length affect prime editing efficiency in correcting the phospholamban R14del cardiomyopathy‐associated mutation. Insights support the design of structurally optimized enhanced pegRNAs for precise gene therapy.
Bing Yao, Qiangbing Yang, Christian J.B. Snijders Blok, Mark A. Daniels, Pieter A. Doevendans, Raymond Schiffelers, Joost P.G. Sluijter, Zhiyong Lei   +7 more
wiley   +1 more source