Results 81 to 90 of about 665,180 (356)

Characteristics of the Kelch domain containing (KLHDC) subfamily and relationships with diseases

FEBS Letters, EarlyView.
The Kelch protein superfamily includes 63 members, with the KLHDC subfamily having 10 proteins. While their functions are not fully understood, recent advances in KLHDC2's structure and role in protein degradation have highlighted its potential for drug development, especially in PROTAC therapies.
Courtney Pilcher, Paula Armina V. Buco, Jia Q. Truong, Paul A. Ramsland, Monique F. Smeets, Carl R. Walkley, Jessica K. Holien   +6 more
wiley   +1 more source

Findings from the Workshop on User-Centered Design of Language Archives [PDF]

, 2016
This white paper describes findings from the workshop on User-Centered Design of Language Archives organized in February 2016 by Christina Wasson (University of North Texas) and Gary Holton (University of Hawai‘i at Mānoa).
Holton, Gary, Roth, Heather, Wasson, Christina   +2 more
core   +1 more source

Exploring individual user differences in the 2D/3D interaction with medical image data [PDF]

, 2009
User-centered design is often performed without regard to individual user differences. In this paper, we report results of an empirical study aimed to evaluate whether computer experience and demographic user characteristics would have an effect on the ...
Dijk, Betsy van, Geest, Rob van der, Reiber, Johan, Schooten, Boris van, Sloot, Peter, Suinesiaputra, Avan, Zudilova-Seinstra, Elena   +6 more
core   +5 more sources

Taurine promotes glucagon‐like peptide‐1 secretion in enteroendocrine L cells

FEBS Letters, EarlyView.
Taurine, a sulfur‐containing amino acid, is likely taken up by enteroendocrine L cells via the taurine transporter. This process increases the levels of cytosolic ATP. The increase in intracellular Ca2+ concentrations and glucagon‐like peptide‐1 secretion through membrane depolarization is caused by the closure of ATP‐sensitive potassium channels ...
Yuri Osuga, Kazuki Harada, Takuya Yamauchi, Tetsuya Kitaguchi, Masami Yokota Hirai, Mitsuharu Matsumoto, Takashi Tsuboi   +6 more
wiley   +1 more source

The multiple roles of the NlpC_P60 peptidase family in mycobacteria – an underexplored target for antimicrobial drug discovery

FEBS Letters, EarlyView.
The NlpC_P60 superfamily of peptidases is recognised by its key role in bacterial cell wall homeostasis. Recently, studies have also described the involvement of NlpC_P60‐like enzymes in bacterial competitive mechanisms and pathogenesis across several lineages.
Catharina dos Santos Silva, Marcio Vinicius Bertacine Dias   +1 more
wiley   +1 more source

Malicious User Experience Design Research for Cybersecurity

, 2018
This paper explores the factors and theory behind the user-centered research that is necessary to create a successful game-like prototype, and user experience, for malicious users in a cybersecurity context.
Sharevski, Filipo, Trowbridge, Adam, Westbrook, Jessica   +2 more
core   +1 more source

Unraveling Mycobacterium tuberculosis acid resistance and pH homeostasis mechanisms

FEBS Letters, EarlyView.
Mycobacterium tuberculosis exhibits a remarkable resilience to acid stress. In this Review, we discuss some of the molecular mechanisms and metabolic pathways used by the tubercle bacilli to adapt and resist host‐mediated acid stress. Mycobacterium tuberculosis (Mtb) is a successful pathogen that has developed a variety of strategies to survive and ...
Janïs Laudouze, Stéphane Canaan, Alexandre Gouzy, Pierre Santucci   +3 more
wiley   +1 more source

Analisis User Interface Website Organisasi Berbasis Task Centered System Design

Patria Artha Technological Journal
Amal Insani merupakan salah satu lembaga kemanusiaan yang membantu sosial masyarakat dengan program kerja dalam kegiatan organisasi mereka. Dalam realitanya, Amal Insani membutuhkan website untuk menjadi media dalam menjangkau lebih banyak donatur dan ...
Irwan Syarif, Rosihan Aminuddin, Muh Rais, Syamsumarlin Taha   +3 more
doaj   +1 more source

An Approach to Decompose and Evaluate a Complex GIS-Application Design to a Simple, Lightweight, User-Centered App-Based Design Using User Experience Evaluation

ISPRS International Journal of Geo-Information, 2020
Working with contemporary, monolithic desktop Geographical Information Systems can be laborious and confusing, especially for non-experts. An alternative for a more user friendly approach to spatial data edition and spatial analysis may be an “app-based”
David Kammerhofer, Johannes Scholz
doaj   +1 more source

The solution supramolecular structure of α2 → 8 polysialic acid suggests a structural cause for its low immunogenicity

FEBS Letters, EarlyView.
α2 → 8 polysialic acid elicits poor immunogenicity. Small‐angle scattering shows a supramolecular structure with parallel‐chain binding, although in different forms at μm and mm calcium. The major histocompatibility complex requires molecular weights around 2000 Da to produce antibodies, and 2000 Da polysialic oligomers will bind in these structures ...
Kenneth A. Rubinson
wiley   +1 more source