Results 91 to 100 of about 1,552,411 (330)

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

KBS Development [PDF]

, 1991
The Knowledge Based System (KBS) has two main objectives, the provision of easy access to all the industrial and scientific codes through an executive program, and the provision of an easy to use user interface for the analysis codes.
Aggarwal, Bharat
core   +1 more source

Brain Computer Interface on Track to Home

TheScientificWorldJournal, 2015
The novel BackHome system offers individuals with disabilities a range of useful services available via brain-computer interfaces (BCIs), to help restore their independence. This is the time such technology is ready to be deployed in the real world, that
F. Miralles, E. Vargiu, Stefan Dauwalder, M. Solà, G. Müller-Putz, S. Wriessnegger, A. Pinegger, A. Kübler, Sebastian Halder, I. Käthner, Suzanne Martin, Jean Daly, Elaine Armstrong, C. Guger, C. Hintermüller, Hannah Lowish   +15 more
semanticscholar   +1 more source

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

Instrumentino: An Open-Source Software for Scientific Instruments

CHIMIA, 2015
Scientists often need to build dedicated computer-controlled experimental systems. For this purpose, it is becoming common to employ open-source microcontroller platforms, such as the Arduino.
Israel Joel Koenka, Jorge Sáiz, Peter C. Hauser   +2 more
doaj   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

EOG Region Detection using Fuzzy k-NN for Virtual Reality Applications

Sakarya Üniversitesi Fen Bilimleri Enstitüsü Dergisi
Virtual Reality (VR) systems have become widespread for a decade with the mass production of VR headsets. Advancement in the VR industry benefits both biomedical and computer gaming fields to create better Human-Computer Interface (HCI) applications.
Emre Güngör, Soydan Serttaş
doaj   +1 more source

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

Design and Optimization of Human-Computer Interaction Interface for Smart Home Energy Management System Based on Machine Learning Load Forecasting

Journal of Applied Science and Engineering
To address the challenges of insufficient load forecasting accuracy and poor human-computer interaction in smart home energy management systems, this study proposes a short-term load forecasting model that integrates a TCN-GRU-Attention framework with a ...
JianYi Li, YingJie Bai, YiJin Chen
doaj   +1 more source

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source