Results 81 to 90 of about 5,479,777 (297)

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Aalto Interface Metrics (AIM): A service and codebase for computational GUI evaluation [PDF]

, 2018
Aalto Interface Metrics (AIM) pools several empirically validated models and metrics of user perception and attention into an easy-to-use online service for the evaluation of graphical user interface (GUI) designs.
Oulasvirta, A., Todi, K., Miniukovich, A., Weinkauf, Tino,, Langerak, T., Koch, Janin, Todi, Kashyap, Koch, J., Laine, M., Palmas, Gregorio,, Laine, Markku, Langerak, Thomas, Kristhombuge, Manoj, Zhu, Yuxi, Oulasvirta, Antti, Miniukovich, Aliaksei, De Pascale, S., Palmas, Gregorio, Kristhombuge, M., De Pascale, Samuli, Jokinen, Jussi, Weinkauf, Tino, Zhu, Y., Jokinen, J.   +23 more
core   +1 more source

Design and Optimization of Human-Computer Interaction Interface for Smart Home Energy Management System Based on Machine Learning Load Forecasting

Journal of Applied Science and Engineering
To address the challenges of insufficient load forecasting accuracy and poor human-computer interaction in smart home energy management systems, this study proposes a short-term load forecasting model that integrates a TCN-GRU-Attention framework with a ...
JianYi Li, YingJie Bai, YiJin Chen
doaj   +1 more source

Design and Implementation of the Control System of an Internal Combustion Engine Test Unit

Advances in Mechanical Engineering, 2014
Accurate tests and performance analysis of engines are required to minimize measurement errors and so the use of the advanced test equipment is imperative.
Tufan Koç, Durmuş Karayel, Barış Boru, Vezir Ayhan, İdris Cesur, Adnan Parlak   +5 more
doaj   +1 more source

Spatial heterogeneity of hotspot mutations and clonal relatedness in ovarian endometrioid carcinoma

Molecular Oncology, EarlyView.
Spatially resolved analysis revealed heterogeneous distributions of selected cancer‐associated mutations within ovarian endometrioid carcinomas. Shared mutations between paired endometrial and ovarian tumors supported clonal relatedness. These findings highlight the value of sampling multiple tumor regions when interpreting molecular profiles ...
Takahito Ashihara, Kosuke Murakami, Shiro Takamatsu, Akiko Kanto, Seiichi Mori, Tomoyuki Otani, Kazuko Sakai, Yasushi Kotani, Kazuto Nishio, Kaoru Abiko, Noriomi Matsumura   +10 more
wiley   +1 more source

User defined face based computer interface

, 2007
Thesis (M. Eng.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 2007.Includes bibliographical references (p.
Wetzel, Jon William
core  

The multifaceted roles of lysosomes in cancer

Molecular Oncology, EarlyView.
Lysosomes support cancer cell adaptation by integrating macromolecule degradation and nutrient recycling with nutrient sensing, inter‐organelle communication and immune regulation. These interconnected functions can promote tumour growth, stress tolerance and therapy resistance, while also creating context‐dependent vulnerabilities that may be ...
Jia Li, Kevin M. Ryan
wiley   +1 more source

The Berlin Brain-Computer Interface presents the novel mental typewriter Hex-o-Spell

, 2022
108109We present a novel typewriter application "Hex-o-Spell" that is specifically tailored to the characteristics of direct brain-to-computer interaction.
Krauledat, M., Dornhege, G., Blankertz, B., Murray-Smith, R., Williamson, J., Schröder, M., Müller, K.-R.   +6 more
core   +1 more source

Instrumentino: An Open-Source Software for Scientific Instruments

CHIMIA, 2015
Scientists often need to build dedicated computer-controlled experimental systems. For this purpose, it is becoming common to employ open-source microcontroller platforms, such as the Arduino.
Israel Joel Koenka, Jorge Sáiz, Peter C. Hauser   +2 more
doaj   +1 more source

An outer membrane vesicle‐associated two‐track model for enterotoxigenic Bacteroides fragilis oncogenesis

Molecular Oncology, EarlyView.
Enterotoxigenic Bacteroides fragilis is a gut bacterium linked to bowel cancer. We propose that its toxin acts along two routes: at the cell surface, cutting the adhesion protein E‐cadherin and triggering inflammation; and inside the cell, delivered by bacterial vesicles, switching on NOD1 and cancer stem cell programs.
Kangchan Choi, Sang‐Hyeon Yoo, Ki‐Jong Rhee   +2 more
wiley   +1 more source