Results 81 to 90 of about 5,058,789 (290)
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Investigating user preferences in utilizing a 2D paper or 3D sketch based interface for creating 3D virtual models [PDF]
, 2014 Computer modelling of 2D drawings is becoming increasingly popular in modern design as can be witnessed in the shift of modern computer modelling applications from software requiring specialised training to ones targeted for the general consumer market ...
Camilleri, Daniel +5 more
core
Journal of Advances in Medical Education and Professionalism, 2018 Introduction: Medical schools face increasing challenges to accommodate new health care needs. However, little has changed regarding the students’ education.
JOSE SEBASTIAO AFONSO +4 more
doaj
Finger-stylus for non touch-enable systems
Journal of King Saud University: Engineering Sciences, 2017 Since computer was invented, people are using many devices to interact with computer. Initially there were keyboard, mouse etc. but with advancement of technology, new ways are being discovered that are quite common and natural to the humans like stylus ...
Ankit Chaudhary
doaj +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Translating whole‐genome doubling into precision medicine in cancer
Molecular Oncology, EarlyView.Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley +1 more source
Applying scenarios in user-centred design to develop a sketching interface for human modelling and animation [PDF]
, 2006 This paper presents our user and usability studies for applying scenarios in user-centred design to develop a sketching interface for virtual human modelling and animation.
Qin, SF, Mao, C, Wright, DK
core +1 more source
Interface Currents : evaluating a fluid interface for tabletop collaboration [PDF]
, 2015 Masters ThesisLarge screen vertical and horizontal displays provide new opportunities to support individual and collaborative activities especially in terms of creativity and design tasks.
Hinrichs, Uta
core +2 more sources
ADP‐ribosylation: An emerging regulator of the epigenome
Molecular Oncology, EarlyView.ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho +2 more
wiley +1 more source
EOG Region Detection using Fuzzy k-NN for Virtual Reality Applications
Sakarya Üniversitesi Fen Bilimleri Enstitüsü DergisiVirtual Reality (VR) systems have become widespread for a decade with the mass production of VR headsets. Advancement in the VR industry benefits both biomedical and computer gaming fields to create better Human-Computer Interface (HCI) applications.
Emre Güngör, Soydan Serttaş
doaj +1 more source