Results 71 to 80 of about 5,479,777 (297)

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source

How structural disorder and polyelectrolyte properties of prothymosin α enable its large interactome

FEBS Letters, EarlyView.
In this review, complexes of the fully disordered and highly negatively charged prothymosin α are collected, described, and discussed. Linked to its poly‐electrostatic character, prothymosin α engages a large interactome through multiple different binding modes ranging from fully disordered complexes to short linear motif (SLiM)‐driven interactions ...
Ketty C. Tamburrini, Freia S. Buus, Benjamin Schuler, Birthe B. Kragelund   +3 more
wiley   +1 more source

Pedagogical mediation using the virtual learning environment and the new generation: A search for improved performance in medical education

Journal of Advances in Medical Education and Professionalism, 2018
Introduction: Medical schools face increasing challenges to accommodate new health care needs. However, little has changed regarding the students’ education.
JOSE SEBASTIAO AFONSO, PEDRO SOUSA MARTINS, GERALDO FELIPE BARBOSA, LUIZ FERREIRA, MANOEL JOAO BATISTA CASTELLO GIRAO   +4 more
doaj  

Finger-stylus for non touch-enable systems

Journal of King Saud University: Engineering Sciences, 2017
Since computer was invented, people are using many devices to interact with computer. Initially there were keyboard, mouse etc. but with advancement of technology, new ways are being discovered that are quite common and natural to the humans like stylus ...
Ankit Chaudhary
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

The Dyslexic User's Interface Support Tool (DUIST) - a framework for performance enhancing interface adaptation strategies for dyslexic computer users [PDF]

Due to the nature of the symptoms experienced by dyslexic individuals (e.g. defective visual processing, short term memory deficit and motor control problems) an investigation into support strategies to aid persons suffering from the condition seems ...
Johnson, Mark
core  

Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology

Molecular Oncology, EarlyView.
This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic, Maria Concetta Vitale, Rita Siino, Emilia Di Giovanni, Carla Ferrante Bannera, Enrico Di Marco, Andrea Gottardo, Tancredi Didier Bazan Russo, Nadia Barraco, Alessandro Perez, Valerio Gristina, Antonio Galvano, Giuseppe Badalamenti, Antonio Russo, Viviana Bazan, Lorena Incorvaia   +15 more
wiley   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

Human-Computer Interface Development: Concepts and Systems for its Management

, 1986
Human-computer interface management, from a computer science viewpoint, focuses on the process of developing quality human computer interfaces, including their representation, design, implementation, execution, evaluation, and maintenance.
Hix, Deborah, Hartson, H. Rex
core  

EOG Region Detection using Fuzzy k-NN for Virtual Reality Applications

Sakarya Üniversitesi Fen Bilimleri Enstitüsü Dergisi
Virtual Reality (VR) systems have become widespread for a decade with the mass production of VR headsets. Advancement in the VR industry benefits both biomedical and computer gaming fields to create better Human-Computer Interface (HCI) applications.
Emre Güngör, Soydan Serttaş
doaj   +1 more source