Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
User Interface Aspects of a Human-Hand Simulation System [PDF]
This paper describes the user interface design for a human-hand simulation system, a virtual environment that produces ground truth data (life-like human hand gestures and animations) and provides visualization support for experiments on computer vision ...
Beifang Yi +3 more
doaj
After the editing is done: Designing a Graphic User Interface for digital editions
With its origins dating back only to the second half of the twentieth century, Computer Science can be considered a very young discipline. The widespread adoption of the "Personal Computer" is even more recent. Introduced in the 1970s, its ascendancy was
Roberto Rosselli Del Turco
doaj +1 more source
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
With the rapid development of artificial intelligence and computer technology, digital interfaces have become central to CNC press operations. However, effectively presenting complex information within limited display space while reducing cognitive load ...
Hao Yuan, Yiting Wang, Jiawei Zhong
doaj +1 more source
An Adaptive Brain Actuated System for Augmenting Rehabilitation
For people living with paralysis, restoration of hand function remains the top priority because it leads to independence and improvement in quality of life.
Scott Alan Roset +3 more
doaj +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Database Graphic User Interface correspondence with Ellis Information Seeking behavior Model
Graphic User interface serves as a bridge between man and databases. Its primary purpose is to assist uses by establishing interaction with computer systems.
Muhammad Azami, Rahmatullah Fatahi
doaj
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Físchlár on a PDA: handheld user interface design to a video indexing, browsing and playback system [PDF]
The Físchlár digital video system is a web-based system for recording, analysis, browsing and playback of TV programmes which currently has about 350 users.
Murphy, Noel +4 more
core +2 more sources

