Results 41 to 50 of about 104,276 (267)

After the editing is done: Designing a Graphic User Interface for digital editions

Digital Medievalist, 2012
With its origins dating back only to the second half of the twentieth century, Computer Science can be considered a very young discipline. The widespread adoption of the "Personal Computer" is even more recent. Introduced in the 1970s, its ascendancy was
Roberto Rosselli Del Turco
doaj   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

An Adaptive Brain Actuated System for Augmenting Rehabilitation

Frontiers in Neuroscience, 2014
For people living with paralysis, restoration of hand function remains the top priority because it leads to independence and improvement in quality of life.
Scott Alan Roset, Katie eGant, Abhishek ePrasad, Justin Cort Sanchez   +3 more
doaj   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Database Graphic User Interface correspondence with Ellis Information Seeking behavior Model

Iranian Journal of Information Processing & Management, 2010
Graphic User interface serves as a bridge between man and databases. Its primary purpose is to assist uses by establishing interaction with computer systems.
Muhammad Azami, Rahmatullah Fatahi
doaj  

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

The Technical Development of a Prototype Lower-Limb Therapy Device for Bed-Resting Users

Actuators
It is generally recommended that bed-resting patients be mobilised early to promote recovery. The aim of this work was to develop and evaluate the usability of a prototype in-bed lower-limb therapy device that offers various training patterns for the ...
Juan Fang, Adrien Cerrito, Simón Gamero Schertenleib, Patrick von Raumer, Kai-Uwe Schmitt   +4 more
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

A Comparative Study on Iranian Journal Management Systems in Universities of Medical Sciences Based on the Usability Components

مدیریت اطلاعات سلامت, 2020
مقدمه: به دلیل توسعه کاربردپذیری سامانه‌های مدیریت نشریات ادواری دانشگاه‌های علوم پزشکی کشور که از پرمخاطب‌ترین سامانه‌های دانشگاهی به شمار می‌روند و همچنین، عدم وجود مطالعات مرتبط، پژوهش حاضر با هدف تعیین هشت مؤلفه کاربردپذیری سیستم‌ها و مقایسه سامانه ...
Amir Mohamad Mozafari-Vanani, Rasool Nouri, Akbar Hassanzadeh, Alireza Rahimi   +3 more
doaj   +1 more source