Results 41 to 50 of about 847,810 (370)

A computer algebra user interface manifesto [PDF]

open access: yes, 2013
Many computer algebra systems have more than 1000 built-in functions, making expertise difficult. Using mock dialog boxes, this article describes a proposed interactive general-purpose wizard for organizing optional transformations and allowing easy fine
Stoutemyer, David R.
core  

Making tau amyloid models in vitro: a crucial and underestimated challenge

open access: yesFEBS Letters, EarlyView.
This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley   +1 more source

KBS Development [PDF]

open access: yes, 1991
The Knowledge Based System (KBS) has two main objectives, the provision of easy access to all the industrial and scientific codes through an executive program, and the provision of an easy to use user interface for the analysis codes.
Aggarwal, Bharat
core   +1 more source

Refining the NaV1.7 pharmacophore of a class of venom‐derived peptide inhibitors via a combination of in silico screening and rational engineering

open access: yesFEBS Letters, EarlyView.
Venom peptides have shown promise in treating pain. Our study uses computer screening to identify a peptide that targets a sodium channel (NaV1.7) linked to chronic pain. We produced the peptide in the laboratory and refined its design, advancing the search for innovative pain therapies.
Gagan Sharma   +8 more
wiley   +1 more source

Interaction Issues in Computer Aided Semantic\ud Annotation of Multimedia [PDF]

open access: yes, 2010
The CASAM project aims to provide a tool for more efficient and effective annotation of multimedia documents through collaboration between a user and a system performing an automated analysis of the media content.
Beale, Russell   +7 more
core  

Identification of novel small molecule inhibitors of ETS transcription factors

open access: yesFEBS Letters, EarlyView.
ETS transcription factors play an essential role in tumourigenesis and are indispensable for sprouting angiogenesis, a hallmark of cancer, which fuels tumour expansion and dissemination. Thus, targeting ETS transcription factor function could represent an effective, multifaceted strategy to block tumour growth. The evolutionarily conserved E‐Twenty‐Six
Shaima Abdalla   +9 more
wiley   +1 more source

miRNA‐29 regulates epidermal and mesenchymal functions in skin repair

open access: yesFEBS Letters, EarlyView.
miRNA‐29 inhibits cell‐to‐cell and cell‐to‐matrix adhesion by silencing mRNA targets. Adhesion is controlled by complex interactions between many types of molecules coded by mRNAs. This is crucial for keeping together the layers of the skin and for regenerating the skin after wounding.
Lalitha Thiagarajan   +10 more
wiley   +1 more source

Data‐driven performance metrics for neural network learning

open access: yesInternational Journal of Adaptive Control and Signal Processing, EarlyView., 2023
Summary Effectiveness of data‐driven neural learning in terms of both local mimima trapping and convergence rate is addressed. Such issues are investigated in a case study involving the training of one‐hidden‐layer feedforward neural networks with the extended Kalman filter, which reduces the search for the optimal network parameters to a state ...
Angelo Alessandri   +2 more
wiley   +1 more source

Leap Motion Sensor for Natural User Interface

open access: yesTehnički Vjesnik, 2019
In Human Computer Interaction (HCI) research area, there is an increasing tendency to make devices as simple and as natural as possible for use. These devices are aiming to make input and output techniques, interaction, etc., easier. In the input domain,
Nenad Breslauer   +3 more
doaj   +1 more source

A reflective characterisation of occasional user [PDF]

open access: yes, 2016
This work revisits established user classifications and aims to characterise a historically unspecified user category, the Occasional User (OU). Three user categories, novice, intermediate and expert, have dominated the work of user interface (UI ...
Carrillo, Antonio L.   +3 more
core   +2 more sources

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