Results 91 to 100 of about 1,312,492 (269)
Managing User Capabilities in Information Systems Life Cycle: Conceptual Modeling
International Journal of Information Science and Management, 2016 Information Systems (IS) acquisition prescribes induction of information technologies (IT) in the organization. At times, IS is used for managing broader enterprise level issues like implementing e-business, e-commerce.
Harekrishna Misra
doaj
IEEE AccessIn this study, we introduce a novel framework for practicing and analyzing arm muscles in motions, such as juggling actions, by estimating the hand motion of the user using a Leap Motion device.
Jong-Hyun Kim, Jung Lee, Youngbin Kim
doaj +1 more source
Time after time – circadian clocks through the lens of oscillator theory
FEBS Letters, EarlyView.Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
wiley +1 more source
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
FedMUP: Federated learning driven malicious user prediction model for secure data distribution in cloud environments [PDF]
Applied Soft ComputingCloud computing is flourishing at a rapid pace. Significant consequences related to data security appear as a malicious user may get unauthorized access to sensitive data which may be misused, further. This raises an alarm-ringing situation to tackle the
Kishu Gupta +4 more
semanticscholar +1 more source
FEBS Letters, EarlyView.Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman +2 more
wiley +1 more source
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
GestUI: A Model-driven Method and Tool for Including Gesture-based Interaction in User Interfaces
Complex Systems Informatics and Modeling Quarterly, 2016 Among the technological advances in touch-based devices, gesture-based interaction have become a prevalent feature in many application domains. Information systems are starting to explore this type of interaction.
Otto Parra, Sergio España, Oscar Pastor
doaj +1 more source