Results 101 to 110 of about 1,150,410 (270)
Using ATL to define advanced and flexible constraint model transformations [PDF]
, 2009 Transforming constraint models is an important task in re- cent constraint programming systems. User-understandable models are defined during the modeling phase but rewriting or tuning them is manda- tory to get solving-efficient models. We propose a new
Chenouard, Raphael +2 more
core +2 more sources
Insightful classification of crystal structures using deep learning
, 2018 Computational methods that automatically extract knowledge from data are critical for enabling data-driven materials science. A reliable identification of lattice symmetry is a crucial first step for materials characterization and analytics.
Ghiringhelli, L. M. +3 more
core +2 more sources
Time after time – circadian clocks through the lens of oscillator theory
FEBS Letters, EarlyView.Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
wiley +1 more source
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
User-Driven Innovation: An Exploratory Study [PDF]
Economic and Business Review, 2015 Despite the relatively robust promotion of user-driven innovation (UDI) in practice, research on UDI remains in its early stages. Following a grounded theory analysis approach, this paper makes a contribution by conducting exploratory research of the ...
Blanka Tacer, Mitja Ruzzier
doaj
DiSCmap : digitisation of special collections mapping, assessment, prioritisation. Final project report [PDF]
, 2009 Traditionally, digitisation has been led by supply rather than demand. While end users are seen as a priority they are not directly consulted about which collections they would like to have made available digitally or why.
Birrell, Duncan +5 more
core +1 more source
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
Are disruptive agricultural technologies compatible with agroecology?
npj Sustainable AgricultureAgroecology has emerged as a credible approach to achieving sustainable and resilient agrifood systems. But the role for disruptive agricultural technologies within agroecology remains contentious.
Helena Shilomboleni, Matthew A. Schnurr
doaj +1 more source
iOLE—Human-Centered Software Design for Leakage Detection in Water Distribution Networks
Engineering ProceedingsLeakages in water distribution networks still pose major challenges to water utilities. Despite numerous technological advances, the adoption of digital leakage detection technology remains a slow process.
Ivo Daniel +9 more
doaj +1 more source
JMIR mHealth and uHealth, 2015 The development of mHealth applications is often driven by the investigators and developers with relatively little input from the targeted population. User input is commonly limited to “like/dislike” post- intervention consumer satisfaction ratings or ...
Bock, Beth C +7 more
doaj +1 more source